Results 41 to 50 of about 13,352,036 (198)

Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies

Nature Chemical Biology, 2013
A new class of glycan-reactive HIV-neutralizing antibodies, including PG9 and PG16, has been recently discovered that appear to recognize novel glycopeptide epitopes on HIV-1 gp120.
M. Amin, J. McLellan, Wei Huang, J. Orwenyo, D. Burton, W. Koff, P. Kwong, Lai-Xi Wang   +7 more
semanticscholar   +1 more source

Changes to serum sample tube and processing methodology does not cause Intra-Individual [corrected] variation in automated whole serum N-glycan profiling in health and disease. [PDF]

PLoS ONE, 2015
Serum N-glycans have been identified as putative biomarkers for numerous diseases. The impact of different serum sample tubes and processing methods on N-glycan analysis has received relatively little attention.
Nicholas T Ventham, Richard A Gardner, Nicholas A Kennedy, Archana Shubhakar, Rahul Kalla, Elaine R Nimmo, IBD-BIOM Consortium, Daryl L Fernandes, Jack Satsangi, Daniel I R Spencer   +9 more
doaj   +1 more source

Advanced Plant-Based Glycan Engineering

Frontiers in Bioengineering and Biotechnology, 2018
With respect to biomanufacturing, glycosylation is one of the most addressed post-translational modifications, since it is well-known that the attachment of sugar residues efficiently affects protein homogeneity and functionality.
Laura Montero-Morales, H. Steinkellner
semanticscholar   +1 more source

Expression and Display of Glycoengineered Antibodies and Antibody Fragments with an Engineered Yeast Strain

Antibodies, 2021
Interactions with cell surface receptors enhance the therapeutic properties of many important antibodies, including the low-affinity Fc γ Receptors (FcγRs). These interactions require proper processing of the immunoglobulin G Fc N-glycan, and eliminating
Anjali Shenoy, Srisaimaneesh Yalamanchili, Alexander R. Davis, Adam W. Barb   +3 more
doaj   +1 more source

Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies

iScience, 2020
Summary: HIV-1 envelope (Env) N-glycosylation impact virus-cell entry and immune evasion. How each glycan interacts to shape the Env-protein-sugar complex and affects Env function is not well understood.
Qing Wei, Audra A. Hargett, Barbora Knoppova, Alexandra Duverger, Reda Rawi, Chen-Hsiang Shen, S. Katie Farney, Stacy Hall, Rhubell Brown, Brandon F. Keele, Sonya L. Heath, Michael S. Saag, Olaf Kutsch, Gwo-Yu Chuang, Peter D. Kwong, Zina Moldoveanu, Milan Raska, Matthew B. Renfrow, Jan Novak   +18 more
doaj  

Serum N-Glycan Markers for Diagnosing Significant Liver Fibrosis and Cirrhosis in Chronic Hepatitis B Patients with Normal Alanine Aminotransferase Levels

Engineering, 2023
The aim of this study was to explore the role of serum N-glycomic-derived models in diagnosing significant liver fibrosis and cirrhosis in 285 chronic hepatitis B (CHB) patients with normal (
Lin Wang, Yiqi Liu, Qixin Gu, Chi Zhang, Lei Xu, Lei Wang, Cuiying Chen, Xueen Liu, Hong Zhao, Hui Zhuang   +9 more
doaj  

Serum Linkage-Specific Sialylation Changes Are Potential Biomarkers for Monitoring and Predicting the Recurrence of Papillary Thyroid Cancer Following Thyroidectomy

Frontiers in Endocrinology, 2022
BackgroundAlthough papillary thyroid cancer (PTC) could remain indolent, the recurrence rates after thyroidectomy are approximately 20%. There are currently no accurate serum biomarkers that can monitor and predict recurrence of PTC after thyroidectomy ...
Zhen Cao, Zejian Zhang, Rui Liu, Mengwei Wu, Zepeng Li, Xiequn Xu, Ziwen Liu   +6 more
doaj   +1 more source

Glycomic Analysis of Life Stages of the Human Parasite Schistosoma mansoni Reveals Developmental Expression Profiles of Functional and Antigenic Glycan Motifs*

Molecular & Cellular Proteomics, 2015
Glycans present on glycoproteins and glycolipids of the major human parasite Schistosoma mansoni induce innate as well as adaptive immune responses in the host.
A. V. Diepen, D. Nguyen, M. Wuhrer, K. Hoffmann, A. Deelder, C. Hokke   +5 more
semanticscholar   +1 more source

Plasma High-Mannose and Complex/Hybrid N-Glycans Are Associated with Hypercholesterolemia in Humans and Rabbits.

PLoS ONE, 2016
N-glycans play important roles in various pathophysiological processes and can be used as clinical diagnosis markers. However, plasma N-glycans change and their pathophysiological significance in the setting of hypercholesterolemia, a major risk factor ...
Liang Bai, Qianwei Li, Lingmei Li, Yan Lin, Sihai Zhao, Weirong Wang, Rong Wang, Yongqin Li, Jiangbei Yuan, Chengjian Wang, Zhongfu Wang, Jianglin Fan, Enqi Liu   +12 more
doaj   +1 more source

Overlooked post-translational modifications of proteins in Plasmodium falciparum: N- and O-glycosylation - A Review

Memorias do Instituto Oswaldo Cruz, 2010
Human malignant malaria is caused by Plasmodium falciparum and accounts for almost 900,000 deaths per year, the majority of which are children and pregnant women in developing countries.
Cristiana S de Macedo, Ralph T Schwarz, Adriane R Todeschini, Jose O Previato, Lucia Mendonça-Previato   +4 more
doaj   +1 more source