Results 61 to 70 of about 13,626,059 (252)

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Monitoring carbohydrate 3D structure quality with the Privateer database

Beilstein Journal of Organic Chemistry
The remediation of the carbohydrate data of the Protein Data Bank (PDB) has brought numerous enhancements to the findability and interpretability of deposited glycan structures, yet crucial quality indicators are either missing or hard to find on the PDB
Jordan S. Dialpuri, Haroldas Bagdonas, Lucy C. Schofield, Phuong Thao Pham, Lou Holland, Jon Agirre   +5 more
doaj   +1 more source

Site-specific N-glycoproteomics reveals alteration of N-glycan structures and heterogeneity to enhance thermally induced gelation characteristics of egg white proteins

Food Chemistry: X
N-glycans are complex carbohydrates crucial for the structural integrity and functionality of proteins. Here, we present a high-resolution egg white protein N-glycoproteomic atlas that systematically unveils the microheterogeneity across N-glycosites ...
Guang Li, Jiao Wang, Pengyun Gong, Yongguo Jin, Bingkun Zhang, Yuming Guo, Zengpeng Lv   +6 more
doaj   +1 more source

New insights into site‐specific N‐glycosylation profiling differences of serum proteomes between colostrum and mature breast milk

Food Frontiers, 2023
N‐glycosylation has important implications for the physicochemical properties and biochemical activity of breast milk proteins. However, an in‐depth characterization of site‐specific N‐glycans in breast milk serum proteins is lacking.
Boyuan Guan, Donghong Liu, Xueyan Cao, Zhenghan Zhang, Xue Bai, Shanshan Zhao, Xue Luo, Daguang Feng, Liu Yang, Xiqing Yue, Xiaoyu Liu   +10 more
doaj   +1 more source

Deep Learning Prediction of O‐Glycopeptide Tandem Mass Spectra Enhances O‐Glycoproteomics

Advanced Science, EarlyView.
DeepGPO integrates Transformer and graph neural networks with tailored training strategies, including data augmentation, loss re‐weighting, and pre‐training, to achieve high‐quality O‐glycopeptide MS/MS spectra prediction. The predicted MS/MS spectra are used to localize O‐glycosylation sites from HCD MS/MS data, enhancing O‐glycoproteomics analysis ...
Yu Zong, Yuxin Wang, Liang Qiao
wiley   +1 more source

Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein.

PLoS Biology, 2019
Cell-to-cell transmission of toxic forms of α-Synuclein (αS) is thought to underlie disease progression in Parkinson disease. αS in humans is constitutively N-terminally acetylated (αSacetyl), although the impact of this modification is relatively ...
Melissa Birol, Slawomir P Wojcik, Andrew D Miranker, Elizabeth Rhoades   +3 more
doaj   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

A chemoenzymatic method for simultaneous profiling N- and O-glycans on glycoproteins using one-pot format

Cell Reports: Methods
Summary: Glycosylation is generally characterized and controlled as a critical quality attribute for therapeutic glycoproteins because glycans can impact protein drug-product efficacy, half-life, stability, and safety.
Uriel Ortega-Rodriguez, John Q. Bettinger, Guozhang Zou, Vincent M. Falkowski, Mari Lehtimaki, Alicia M. Matthews, Thomas G. Biel, Jordan D. Pritts, Wells W. Wu, Rong-Fong Shen, Cyrus Agarabi, V. Ashutosh Rao, Hang Xie, Tongzhong Ju   +13 more
doaj   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain

, 2003
The ligand-binding domains of AMPA receptor subunits carry two conserved N-glycosylation sites. In order to gain insight into the functional role of the corresponding N-glycans, we examined how the elimination of glycosylation at these sites (N407 and ...
Sarah K. Coleman, Jean Rossier, Michael Pasternack, Jean-Pierre LeCaer, Kari Keinänen, Arja Pasternack, James Féthière, Dean R. Madden   +7 more
core   +1 more source