Results 81 to 90 of about 10,628,077 (304)

Comparisons of N-glycans across invertebrate phyla [PDF]

Parasitology, 2019
AbstractMany invertebrates are either parasites themselves or vectors involved in parasite transmission; thereby, the interactions of parasites with final or intermediate hosts are often mediated by glycans. Therefore, it is of interest to compare the glycan structures or motifs present across invertebrate species.
Katharina Paschinger, Iain B. H. Wilson
openaire   +2 more sources

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source

Predominant Expression of Hybrid N-Glycans Has Distinct Cellular Roles Relative to Complex and Oligomannose N-Glycans

, 2016
Glycosylation modulates growth, maintenance, and stress signaling processes. Consequently, altered N-glycosylation is associated with reduced fitness and disease.
Schwalbe, Ruth, Dayal, Sahil, Hall, M. Kristen, Austin Whitman, Yong Zhu, M. Hall, Douglas Weidner, Ruth Schwalbe, Zhu, Young, Sahil Dayal, Weidner, Douglas A., Whitman, Austin A.   +11 more
core   +2 more sources

A chemoenzymatic method for simultaneous profiling N- and O-glycans on glycoproteins using one-pot format

Cell Reports: Methods
Summary: Glycosylation is generally characterized and controlled as a critical quality attribute for therapeutic glycoproteins because glycans can impact protein drug-product efficacy, half-life, stability, and safety.
Uriel Ortega-Rodriguez, John Q. Bettinger, Guozhang Zou, Vincent M. Falkowski, Mari Lehtimaki, Alicia M. Matthews, Thomas G. Biel, Jordan D. Pritts, Wells W. Wu, Rong-Fong Shen, Cyrus Agarabi, V. Ashutosh Rao, Hang Xie, Tongzhong Ju   +13 more
doaj   +1 more source

New insights into site‐specific N‐glycosylation profiling differences of serum proteomes between colostrum and mature breast milk

Food Frontiers, 2023
N‐glycosylation has important implications for the physicochemical properties and biochemical activity of breast milk proteins. However, an in‐depth characterization of site‐specific N‐glycans in breast milk serum proteins is lacking.
Boyuan Guan, Donghong Liu, Xueyan Cao, Zhenghan Zhang, Xue Bai, Shanshan Zhao, Xue Luo, Daguang Feng, Liu Yang, Xiqing Yue, Xiaoyu Liu   +10 more
doaj   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein.

PLoS Biology, 2019
Cell-to-cell transmission of toxic forms of α-Synuclein (αS) is thought to underlie disease progression in Parkinson disease. αS in humans is constitutively N-terminally acetylated (αSacetyl), although the impact of this modification is relatively ...
Melissa Birol, Slawomir P Wojcik, Andrew D Miranker, Elizabeth Rhoades   +3 more
doaj   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Monitoring carbohydrate 3D structure quality with the Privateer database

Beilstein Journal of Organic Chemistry
The remediation of the carbohydrate data of the Protein Data Bank (PDB) has brought numerous enhancements to the findability and interpretability of deposited glycan structures, yet crucial quality indicators are either missing or hard to find on the PDB
Jordan S. Dialpuri, Haroldas Bagdonas, Lucy C. Schofield, Phuong Thao Pham, Lou Holland, Jon Agirre   +5 more
doaj   +1 more source

Regulation of Integrin Functions by N‐Glycans

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
openaire   +2 more sources