Results 71 to 80 of about 10,628,077 (304)

Characterization of the single-chain Fv-Fc antibody MBP10 produced in Arabidopsis alg3 mutant seeds

, 2010
ER resident glycoproteins, including ectopically expressed recombinant glycoproteins, carry so-called high-mannose type N-glycans, which can be at different stages of processing.
Maurice Henquet, Alexander van der Krol, Mariëlle Schreuder, Schreuder, M., Dirk Bosch, Cordewener, J., Schreuder, M.E.L., Depicker, A., Eigenhuijsen, Jochem, Jan Cordewener, Hesselink, T., Depicker, Anna, Bosch, D., Ann Depicker, Henquet, M.G.L., Spiegel, Holger, Henquet, M., Thamara Hesselink, Spiegel, H., Depicker, AnnaWE098010003776500000-0003-0105-7407F3E47A04-F0ED-11E1-A9DE-61C894A0A6B4, Henquet, Maurice, Jochem Eigenhuijsen, Cordewener, J.H.G., Schreuder, Mariëlle, van der Krol, Alexander, Bosch, H.J., Duijn, E., van, van Duijn, E., Krol, A.R., van der, Hesselink, Thamara, van Duijn, Esther, Cordewener, Jan, Eigenhuijsen, J., Bosch, Dirk, Esther van Duijn, Holger Spiegel, van der Krol, A.R.   +36 more
core   +1 more source

Divergent Enzymatic Assembly of a Comprehensive 64‐Membered IgG N‐Glycan Library for Functional Glycomics

Advanced Science, 2023
N‐Glycosylation, a main post‐translational modification of Immunoglobulin G (IgG), plays a significant role in modulating the immune functions of IgG. However, the precise function elucidation of IgG N‐glycosylation remains impeded due to the obstacles ...
Wenjing Ma, Zhuojia Xu, Yuhan Jiang, Jialin Liu, Dandan Xu, Wei Huang, Tiehai Li   +6 more
doaj   +1 more source

Mechanically Spatio‐Chimeric Fibrin Assembly Enables Vascular‐Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair

Advanced Materials, EarlyView.
SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung, Minjun Kim, Da‐Yoon Kim, Min Kyu Kim, Sieun Lee, Yoonhee Jin, Joo H. Kang   +6 more
wiley   +1 more source

An enzymatic strategy to asymmetrically branched N-glycans [PDF]

Organic & Biomolecular Chemistry, 2017
Using a set of glycosidases and glycosyltransferases, an enzymatic strategy was developed to prepare asymmetricN-glycans excluding any chemical procedures.
Angie D. Calderon, Jun Zhou, Wanyi Guan, Zhigang Wu, Yuxi Guo, Jing Bai, Qing Li, Peng George Wang, Junqiang Fang, Lei Li   +9 more
openaire   +2 more sources

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Glycointeractome of Neisseria gonorrhoeae: Identification of Host Glycans Targeted by the Gonococcus To Facilitate Adherence to Cervical and Urethral Epithelial Cells

mBio, 2019
Neisseria gonorrhoeae is a significant threat to global health for which a vaccine and novel treatment options are urgently needed. Glycans expressed by human cells are commonly targeted by pathogens to facilitate interactions with the host, and thus ...
Evgeny A. Semchenko, Arun V. Everest-Dass, Freda E.-C. Jen, Tsitsi D. Mubaiwa, Christopher J. Day, Kate L. Seib   +5 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

N-Glycan Modification in Aspergillus Species [PDF]

Applied and Environmental Microbiology, 2008
ABSTRACT The production by filamentous fungi of therapeutic glycoproteins intended for use in mammals is held back by the inherent difference in protein N-glycosylation and by the inability of the fungal cell to modify proteins with mammalian glycosylation structures. Here, we report protein N-glycan engineering in two
Elke, Kainz, Andreas, Gallmetzer, Christian, Hatzl, Juergen H, Nett, Huijuan, Li, Thorsten, Schinko, Robert, Pachlinger, Harald, Berger, Yazmid, Reyes-Dominguez, Andreas, Bernreiter, Tillmann, Gerngross, Stefan, Wildt, Joseph, Strauss   +12 more
openaire   +2 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain

, 2003
The ligand-binding domains of AMPA receptor subunits carry two conserved N-glycosylation sites. In order to gain insight into the functional role of the corresponding N-glycans, we examined how the elimination of glycosylation at these sites (N407 and ...
Sarah K. Coleman, Jean Rossier, Michael Pasternack, Jean-Pierre LeCaer, Kari Keinänen, Arja Pasternack, James Féthière, Dean R. Madden   +7 more
core   +1 more source