Divergent Enzymatic Synthesis of a Comprehensive Type‑1 Glycan Determinant Library. [PDF]
ACS CatalBai G +6 more
europepmc +1 more source
Combination of racotumomab immunotherapy with programmed death-1 blockade in a preclinical model of non-small cell lung cancer. [PDF]
Transl Lung Cancer ResSegatori VI +9 more
europepmc +1 more source
Enzymatic tailoring of anionic glycans for characterizing lectin and antibody specificities in a microarray format. [PDF]
J Biol ChemNuschy L, Wilson IBH.
europepmc +1 more source
N-Glycolylneuraminic acid specific lectin from Pilaglobosa snail
Biochemical and Biophysical Research Communications, 1991 A N-glycolylneuraminic acid-specific lectin (PAL) has been purified from an albumin gland extract of the apple snail, Pila globosa. Purification is conducted on a bovine submaxillary mucin-Sepharose 4B affinity matrix followed by gel filtration on a Sepharose 6B column. The lectin agglutinates rabbit erythrocytes.
Snehasikta Swarnakar +2 more
exaly +4 more sources
Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M [PDF]
Biochemical and Biophysical Research Communications, 2018 N-glycolylneuraminic acid (Neu5Gc)-containing glycans are a prominent form of aberrant glycosylation found in human tumor cells and have been proposed as cancer biomarkers. The B subunit of the subtilase cytotoxin (SubB) produced by Shiga toxigenic Escherichia coli recognises Neu5Gc containing glycans. We have previously engineered this lectin, SubB2M,
James Paton +2 more
exaly +5 more sources
Microwave-assisted synthesis of N-glycolylneuraminic acid derivatives
Tetrahedron Letters, 2013 Abstract A rapid, efficient and scalable synthesis of biologically-relevant N-glycolylneuraminic acid derivatives from the natural N-acetyl (Neu5Ac) precursors has been developed. Microwave irradiation provides accelerated de-N-acetylation compared to more traditional methods, with optimised NaOH-promoted de-N-acetylation in only 15 min. The prepared
Mark von Itzstein +2 more
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Straightforward access to 2,3- and 3,4-unsaturated derivatives of N-glycolylneuraminic acid [PDF]
Tetrahedron, 2020 The facile syntheses of previously unreported 2,3- and 3,4-unsaturated derivatives of N-glycolylneuraminic acid are herein described. The procedure involves a ring-opening of the 4,5-oxazoline of N-acetylneuraminic acid, the acylation of the intermediate
Paola Rota +2 more
exaly +3 more sources
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Current views on N-glycolylneuraminic acid in therapeutic recombinant proteins
Trends in Pharmacological Sciences, 2021The incorporation of the non-human N-glycolylneuraminic acid (Neu5Gc) in therapeutic recombinant proteins raises clinical concerns due to its immunogenic potential and the high prevalence of pre-existing anti-Neu5Gc antibodies in humans. The scientific literature is ambiguous regarding the actual impact of Neu5Gc-containing biotherapeutics as no severe
Horst Bierau +2 more
exaly +3 more sources
Stem Cells, 2007 Human embryonic and mesenchymal stem cell therapies may offer significant benefit to a large number of patients. Recently, however, human embryonic stem cell lines cultured on mouse feeder cells were reported to be contaminated by the xeno-carbohydrate N-
Tero Satomaa +2 more
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Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis [PDF]
Journal of Allergy and Clinical Immunology, 2018 BACKGROUND: Childhood exposure to a farm environment has been shown to protect against the development of inflammatory diseases, such as allergy, asthma, and inflammatory bowel disease.
Jon Genuneit +2 more
exaly +7 more sources