Results 151 to 160 of about 15,525,833 (178)

N-Glycolylneuraminic acid in human tumours.

Biochimie, 2002
N-Glycolylneuraminic acid (Neu5Gc) is an abundant sialic acid, occurring in the glycoconjugates of most deuterostome animals. Homo sapiens is a notable exception, since Neu5Gc is effectively absent from normal human tissues. This is due to a deletion in the human gene coding for CMP-Neu5Ac hydroxylase, the enzyme usually responsible for Neu5Gc ...
Y N, Malykh, R, Schauer, L, Shaw
openaire   +2 more sources

N-glycolylneuraminic acid deficiency in humans

Biochimie, 2001
Classic studies suggested that the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) is an oncofetal antigen in humans, being immunogenic in adult humans and yet apparently expressed in human fetuses and tumors. We and others have recently found that the human deficiency of Neu5Gc can be explained by an inactivating mutation in the gene ...
openaire   +2 more sources

Low incidence of N-glycolylneuraminic acid in birds and reptiles and its absence in the platypus

Carbohydrate Research, 2009
The sialic acids of the platypus, birds, and reptiles were investigated with regard to the occurrence of N-glycolylneuraminic (Neu5Gc) acid. They were released from tissues, eggs, or salivary mucin samples by acid hydrolysis, and purified and analyzed by thin-layer chromatography, high-performance liquid chromatography, and mass spectrometry. In muscle
Yann Guerardel, Jean-Pierre Zanetta
exaly   +4 more sources

The serum dependence of the occurrence of N-glycolylneuraminic acid in HeLa cells

Biochimica et Biophysica Acta (BBA) - General Subjects, 1973
Abstract The occurrence of N -glycolylneuraminic acid in HeLa cells is shown to be due to the calf serum added to the growth medium, and not to their cancerous nature. When Hela cells are grown with human serum as supplement, only N -acetylneuraminic acid can be found. The ganglioside composition of these cells is also reported.
L, Hof, H, Faillard
openaire   +2 more sources

Neu5Gc (N-Glycolylneuraminic Acid)

2020
Among a group of SAs, NeuAc and NeuGc are two of the most common derivatives. SA biosynthesis begins at the cytosol and the synthesized SA is converted to activated nucleotide saccharide form in the nucleus. The activated SA is delivered to Golgi apparatus for ST reaction. STs add SA residues to the terminal sugars of the glycolipids, especially of the
openaire   +1 more source

Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum

Xenotransplantation, 2002
Abstract: The first and major clinical obstacle in xenotransplantation is antibody‐mediated hyperacute rejection. Although human natural antibodies against Galα1,3Gal (Gal) antigens, which are common on porcine cells and organs, have been identified to play a major role in hyperacute rejection, other natural antibodies against non‐Gal epitopes may be ...
Alex, Zhu, Rosa, Hurst
exaly   +3 more sources

Neuraminic Acids/Sialic Acids (N-acetyl- and N-glycolylneuraminic Acid)

2020
Currently, the three domains in life include eukaryote, archaea, and bacteria to organize life as representatives. Archaea and bacteria consist of organisms having prokaryotic cells or prokaryotes. Domain eukaryote includes kingdom plantae, kingdom fungi, kingdom animalia, and protists. Only protists include multiple kingdoms.
openaire   +1 more source

Generation of murine monoclonal antibodies specific for N-glycolylneuraminic acid-containing gangliosides

Archives of Biochemistry and Biophysics, 1992
We generated two murine monoclonal antibodies (MAbs) specific for mono- and disialylgangliosides having N-glycolylneuraminic acid (NeuGc) as their sialic acid moiety, respectively, by immunizing C3H/HeN mice with these purified gangliosides adsorbed to Salmonella minnesota followed by fusion with mouse myeloma cells.
H, Ozawa, I, Kawashima, T, Tai
openaire   +2 more sources

Are N‐glycolylneuraminic acid (Hanganutziu–Deicher) antigens important in pig‐to‐human xenotransplantation?

Xenotransplantation, 2004
Abstract:  Background:  N‐glycolylneuraminic acid (NeuGc) epitopes, so called Hanganutziu–Deicher (HD) antigens, which are widely expressed on endothelial cells of all mammals except humans, are considered to be potential targets for natural and elicited anti‐nonGalα1‐3 Gal (Gal) antibodies in humans.
Yuko, Miwa, Takaaki, Kobayashi, Takaharu, Nagasaka, DaGe, Liu, Ma, Yu, Itsuo, Yokoyama, Akemi, Suzuki, Akimasa, Nakao   +7 more
openaire   +2 more sources

Fabrication of pH-Adjusted Boronic Acid–Aptamer Conjugate for Electrochemical Analysis of Conjugated N-Glycolylneuraminic Acid

ACS Applied Materials & Interfaces, 2020

exaly