Results 91 to 100 of about 3,818 (198)

Immunometabolism of Liver Xenotransplantation and Prospective Solutions

Advanced Science, Volume 12, Issue 9, March 6, 2025.
After xenotransplantation, pig livers will replace those of human patients to maintain the stability of metabolism and immune system. The incompatibility of immunometabolism between humans and pigs induces rejection, inflammation, coagulation dysfunction, and liver failure. The profile of immunometabolism pre‐transplantation and post‐transplantation is
Shoulong Deng, Yi Zhang, Shasha Shen, Chongyang Li, Chuan Qin   +4 more
wiley   +1 more source

Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant

ACS Catalysis, 2019
N-Glycolylneuraminic acid (Neu5Gc) is a common cell-surface ligand in animals which is not biosynthesized in humans, but it can be acquired in human tissue from dietary sources such as red meat.
Ashley P. Mattey, W. Birmingham, P. Both, Nico Kress, Kun Huang, Jolanda M. van Munster, Gregory S. Bulmer, F. Parmeggiani, Josef Voglmeir, J. R. Martínez, N. Turner, S. Flitsch   +11 more
semanticscholar   +1 more source

Characterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation—A narrative review

American Journal of Hematology, Volume 100, Issue 2, Page 285-295, February 2025.
Abstract The recent report of the first pig kidney transplant in a living human brings hope to thousands of people with end‐stage kidney failure. The scientific community views this early success with caution as kidney xenotransplantation exhibits many challenges and barriers. One of these is coagulation dysregulation.
Ali Zidan, Adham H. El‐Sherbini, Abdelrahman Noureldin, David K. C. Cooper, Maha Othman   +4 more
wiley   +1 more source

Sialic acids Neu5Ac and KDN in adipose tissue samples from individuals following habitual vegetarian or non-vegetarian dietary patterns

Scientific Reports, 2023
Sialic acids (Sias) are a class of sugar molecules with a parent nine-carbon neuraminic acid, generally present at the ends of carbohydrate chains, either attached to cellular surfaces or as secreted glycoconjugates.
Gerardo N. Guerrero-Flores, Fabio J. Pacheco, Danilo S. Boskovic, Sandaly O. S. Pacheco, Guangyu Zhang, Gary E. Fraser, Fayth L. Miles   +6 more
doaj   +1 more source

Detection Strategies for Sialic Acid and Sialoglycoconjugates

ChemBioChem, Volume 25, Issue 23, December 2, 2024.
Sialic acid is a glycan residue found at the termini of many glycoconjugates. This residue, and the underlying residues it covers, form critical recognition epitopes in glycobiology. In this review we discuss methods to detect sialoglycoconjugates and sialic acids which are either substrates or products of the enzymes that form these conjugates ...
Carmanah D. Hunter, Christopher W. Cairo
wiley   +1 more source

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc

Frontiers in Immunology, 2019
The description of “serum sickness” more than a century ago in humans transfused with animal sera eventually led to identification of a class of human antibodies directed against glycans terminating in the common mammalian sialic acid N ...
Chirag Dhar, Chirag Dhar, Aniruddha Sasmal, Aniruddha Sasmal, Ajit Varki, Ajit Varki   +5 more
doaj   +1 more source

Transposable element insertions have strongly affected human evolution [PDF]

, 2010
Comparison of a full collection of the transposable element (TE) sequences of vertebrates with genome sequences shows that the human genome makes 655 perfect full-length matches.
Britten, Roy J.
core   +2 more sources

Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain*♦

Journal of Biological Chemistry, 2017
All vertebrate cell surfaces display a dense glycan layer often terminated with sialic acids, which have multiple functions due to their location and diverse modifications.
Yuko Naito-Matsui, Leela R. L. Davies, H. Takematsu, Hsun-Hua Chou, P. Tangvoranuntakul, A. Carlin, A. Verhagen, C. Heyser, Seung-Wan Yoo, B. Choudhury, J. Paton, A. Paton, N. Varki, R. Schnaar, A. Varki   +14 more
semanticscholar   +1 more source

Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation

Advanced Science, Volume 11, Issue 31, August 21, 2024.
Type 1 diabetes mellitus (T1DM) arises from insulin deficiency resulting from the destruction of pancreatic β‐cells. Treatment usually entails daily insulin injections, but challenges endure. Allogeneic pancreatic islet transplantation holds promise, yet its viability is constrained by organ scarcity.
Sarah Grimus, Victoria Sarangova, Petra B. Welzel, Barbara Ludwig, Jochen Seissler, Elisabeth Kemter, Eckhard Wolf, Asghar Ali   +7 more
wiley   +1 more source

Complexity and modification of the bull sperm glycocalyx during epididymal maturation

The FASEB Journal, Volume 38, Issue 10, 31 May 2024.
Modification of the bull sperm glycocalyx during epididymal maturation. Abstract Mammalian spermatozoa have a surface covered with glycocalyx, consisting of heterogeneous glycoproteins and glycolipids. This complexity arises from diverse monosaccharides, distinct linkages, various isomeric glycans, branching levels, and saccharide sequences.
Petra Sečová, Lenka Hackerová, Ľubica Horovská, Katarína Michalková, Jana Jankovičová, Pavla Postlerová, Jana Antalíková   +6 more
wiley   +1 more source