Results 71 to 80 of about 15,627,773 (170)

Detection of Neu5Gc Tumour Antigens

, 2023
Aberrant glycosylation is a common feature of all human cancer cells and plays roles in tumour progression by modulating tumour proliferation, invasion and metastasis.
Wang, Jing
core   +1 more source

The use of transgenic animals for xenotransplantation: An update

Animal Models and Experimental Medicine, Volume 8, Issue 11, Page 2041-2052, November 2025.
One way to produce genetically modified pigs is to use somatic cell nuclear transfer (SCNT). This procedure involves removing the metaphase plate from a mature oocyte using micromanipulation and then transferring the modified nucleus from the donor somatic cell to the oocyte.
Julia Motławska, Ana Amaral, Marta Cerveira‐Pinto, Paweł Kordowitzki   +3 more
wiley   +1 more source

N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible

, 2007
Human embryonic and mesenchymal stem cell therapies may offer significant benefit to a large number of patients. Recently, however, human embryonic stem cell lines cultured on mouse feeder cells were reported to be contaminated by the xeno-carbohydrate N-
Heiskanen, Annamari, Tuuri, Timo, Otonkoski, Timo, Mikkola, Milla, Impola, Ulla, Tiitinen, Sari, Blomqvist, Maria K.,, Laine, Jarmo, Salo, Hanna, Natunen, Jari, Satomaa, Tero, Olsson, Cia, Olonen, Anne, Mannelin, Sirkka, Saarinen, Juhani, Laitinen, Anita, Miller-Podraza, Halina,, Lehenkari, Petri   +17 more
core   +1 more source

Potential Effects of Three Forms of Sialic Acid on Intestinal Health in Obese Mice Fed With a High‐Fat Diet

Food Frontiers, Volume 6, Issue 6, Page 3090-3107, November 2025.
A high‐fat diet impairs intestinal health by disrupting the mucus layer, widening epithelial gaps, triggering inflammation, and causing microbial dysbiosis, ultimately leading to obesity and metabolic disorders. Sialic acid interventionsparticularly bound forms (3ʹ‐SL and EBN)outperform free Neu5Ac in restoring microbial balance, alleviating ...
Xinyue Wang, Wei Zhang, Xinyuan Huang, Linlin Zhou, Xinning Zhao, Hanying Zheng, Xudan Shen, Xinyi Wang, Lili Pan, Yahui Li, Hongwei Li   +10 more
wiley   +1 more source

Revolutionizing Heart Valve Therapy: A Translational Framework for Combining Decellularized Scaffolds With Genetic Modification

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.
ABSTRACT Valvular heart disease (VHD) represents a significant global health challenge, affecting over 2.5% of the population and disproportionately impacting older adults due to age‐related degenerative processes. Current treatment options—mechanical and bioprosthetic valves—both present substantial limitations that impact patient quality of life and ...
Nikolaos P. Tzavellas, Natalia Atzemoglou, Efstathios L. Pavlidis, Alkinoos Nikolis, Georgios S. Markopoulos, Konstantinos I. Tsamis, Dimitrios Peschos, Yannis V. Simos, Lampros Lakkas   +8 more
wiley   +1 more source

Selective Oxidation of N‑Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant

, 2019
N-Glycolylneuraminic acid (Neu5Gc) is a common cell-surface ligand in animals which is not biosynthesized in humans, but it can be acquired in human tissue from dietary sources such as red meat.
Nico Kress (7146680), Jolanda M. van Munster (687161), William R. Birmingham, Juana E. R. Martinez (7146683), Nicholas J. Turner, Juana E. R. Martinez, Peter Both, Nico Kress, Gregory S. Bulmer, Ashley P. Mattey (7146677), William R. Birmingham (2107420), Fabio Parmeggiani (691842), Gregory S. Bulmer (6659336), Josef Voglmeir (1466209), Fabio Parmeggiani, Sabine L. Flitsch (212529), Josef Voglmeir, Kun Huang (136241), Sabine L. Flitsch, Nicholas J. Turner (225510), Kun Huang, Peter Both (2103751), Ashley P. Mattey, Jolanda M. van Munster   +23 more
core   +1 more source

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc

Frontiers in Immunology, 2019
The description of “serum sickness” more than a century ago in humans transfused with animal sera eventually led to identification of a class of human antibodies directed against glycans terminating in the common mammalian sialic acid N ...
Chirag Dhar, Chirag Dhar, Aniruddha Sasmal, Aniruddha Sasmal, Ajit Varki, Ajit Varki   +5 more
doaj   +1 more source

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
wiley   +1 more source

Developments in Ion Exchange Chromatography–Mass Spectrometry for the Characterization of Intact Proteins and Proteoforms

Journal of Separation Science, Volume 48, Issue 9, September 2025.
ABSTRACT Ion exchange chromatography (IEC) hyphenated to mass spectrometry (MS) is a powerful non‐denaturing technique used for analyzing protein charge heterogeneity (including posttranslational modifications such as deamidation, phosphorylation, and sialylation), as well as for characterizing complex protein mixtures. This review provides an overview
Ziran Zhai, Thomas Holmark, Lars Jasperse, Andrea F. G. Gargano   +3 more
wiley   +1 more source

The milk metabolome and its potential utilisation for enhanced dairy processing

International Journal of Dairy Technology, Volume 78, Issue 3, July–September 2025.
The milk metabolome can be affected by a variety of different intrinsic and extrinsic factors, which can subsequently affect important parameters of milk quality and processability. This review explores this relationship and provides an overview of the topic of milk metabolomics as an ever‐evolving field of study.
Paula Rojas‐Gómez, Raghunath Pariyani, Noel A McCarthy, Lorraine M Bateman, James A O'Mahony, Tom F O'Callaghan   +5 more
wiley   +1 more source