Results 51 to 60 of about 15,627,773 (170)
Mass Spectrometry Reviews, EarlyView.ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley +1 more source
Gene expression and pathway analysis of effects of the CMAH deactivation on mouse lung, kidney and heart. [PDF]
PLoS ONE, 2014 N-glycolylneuraminic acid (Neu5Gc) is generated by hydroxylation of CMP-Neu5Ac to CMP-Neu5Gc, catalyzed by CMP-Neu5Ac hydroxylase (CMAH). However, humans lack this common mammalian cell surface molecule, Neu5Gc, due to inactivation of the CMAH gene ...
Deug-Nam Kwon +2 more
doaj +1 more source
Frontiers in Medicine, 2021 Adeno-associated virus (AAV) vectors are promising candidates for gene therapy. However, a number of recent preclinical large animal studies failed to translate into the clinic. This illustrates the formidable challenge of choosing the animal models that
Estrella Lopez-Gordo +6 more
doaj +1 more source
Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential
Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber +4 more
wiley +1 more source
Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M [PDF]
, 2018 N-glycolylneuraminic acid (Neu5Gc)-containing glycans are a prominent form of aberrant glycosylation found in human tumor cells and have been proposed as cancer biomarkers.
Wang, JJ +17 more
core +1 more source
A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. [PDF]
PLoS ONE, 2013 N-glycolylneuraminic acid (Neu5Gc) is an immunogenic sugar of dietary origin that metabolically incorporates into diverse native glycoconjugates in humans.
Vered Padler-Karavani +5 more
doaj +1 more source
Comparison of sialic acid content in bovine and buffalo milk and meat
Revista Científica, 2023 Animal-origin food, such as meat and milk, are important sources of sialic acids (SIAs) with relevant implications for human health. Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc).
Michela Contò +2 more
doaj +1 more source
Involvement of a Non-Human Sialic Acid in Human Cancer
Frontiers in Oncology, 2014 Sialic acids are common monosaccharides that are widely expressed as outer terminal units on all vertebrate cell surfaces, and play fundamental roles in cell-cell and cell-microenvironment interactions.
Annie eSamraj +3 more
doaj +1 more source
Journal of Biomedical Materials Research Part A, Volume 114, Issue 7, July 2026.Genetically modified, α‐Gal‐depleted porcine pericardium and wild type tissues are investigated for hemocompatibility and material properties such as mechanobiology and ECM profile to carve out the suitability of the gene‐modified tissue as material for biological heart valve prostheses. ABSTRACT Xenogeneic pericardium is the main source for biological
Claudia Dittfeld +7 more
wiley +1 more source
Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen [PDF]
, 2014 Xenograft rejection of pigs organs with an engineered mutation in the GGTA-1 gene (GTKO) remains a predominantly antibody mediated process which is directed to a variety of non-Gal protein and carbohydrate antigens.
Kogelberg, H +4 more
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