Results 31 to 40 of about 15,524,867 (163)

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway

Toxins, 2023
N-glycolylneuraminic acid (Neu5Gc) is a specific factor in red meat that induces intestinal disease. Our aim was to investigate the effect of Neu5Gc on the intestinal barrier as well as its mechanism of endocytosis and exocytosis. Ten specific inhibitors
Enqi He, Wei Quan, Jie Luo, Chuxin Liu, Wanting Zheng, Qingwu Shen   +5 more
doaj   +1 more source

Structure aided design of a Neu5Gc specific lectin

Scientific Reports, 2017
Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2–3-linked N-glycolylneuraminic acid (Neu5Gc).
Christopher J. Day, Adrienne W. Paton, Melanie A. Higgins, Lucy K. Shewell, Freda E.-C. Jen, Benjamin L. Schulz, Brock P. Herdman, James C. Paton, Michael P. Jennings   +8 more
doaj   +1 more source

Exposure of Children to Rural Lifestyle Factors Associated With Protection Against Allergies Induces an Anti-Neu5Gc Antibody Response

Frontiers in Immunology, 2019
Rural lifestyle has been shown to be highly protective against the development of allergies. Contact to farm-animals or pets and early-life consumption of milk products turned out to be important.
Remo Frei, Remo Frei, Caroline Roduit, Caroline Roduit, Caroline Roduit, Ruth Ferstl, Ruth Ferstl, Liam O'Mahony, Roger P. Lauener, Roger P. Lauener   +9 more
doaj   +1 more source

Electrochemical Evaluation of Tumor Development via Cellular Interface Supported CRISPR/Cas Trans-Cleavage

Research, 2022
Evaluating tumor development is of great importance for clinic treatment and therapy. It has been known that the amounts of sialic acids on tumor cell membrane surface are closely associated with the degree of cancerization of the cell. So, in this work,
Liangfen Cheng, Fuhan Yang, Longfei Tang, Lelin Qian, Xu Chen, Feng Guan, Juan Zhang, Genxi Li   +7 more
doaj   +1 more source

Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid

Frontiers in Immunology, 2020
The emerging field of biotherapeutics provides successful treatments for various diseases, yet immunogenicity and limited efficacy remain major concerns for many products.
Sharon Yehuda, Vered Padler-Karavani
doaj   +1 more source

Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah(−/−)mdx Mice [PDF]

, 2021
Humans cannot synthesize the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an inactivating deletion in the cytidine-5'-monophospho-(CMP)–N-acetylneuraminic acid hydroxylase (CMAH) gene responsible for its synthesis.
Martin, Paul T, Ashbrook, Anna, Maki, Agatha, Chen, Xi, Varki, Ajit, Golden, Bethannie, Okerblom, Jonathan, Janssen, Paul M.L., Crowe, Kelly E, Janssen, Paul ML, Yu, Hai, Diaz, Sandra, Crowe, Kelly E., Samraj, Annie, Kawanishi, Kunio, Zygmunt, Deborah A, Zygmunt, Deborah A., Martin, Paul T.   +17 more
core   +1 more source

Theoretical Studies on the Electronic Structure Parameters and Reactive Activity of Neu5Gc and Neu5Ac under Food Processing Solvent Environment

Molecules, 2019
The animal product hazard factor N-glycolylneuraminic (Neu5Gc) and brain nutrient substance N-acetylneuraminic acid (Neu5Ac) were studied at the M062X/6-311 + G(d,p) geometry optimization level.
Rui Chang, Bowen Yang, Qiu-Jin Zhu
doaj   +1 more source

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid [PDF]

, 2010
The nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) is metabolically incorporated into human tissues from certain mammalian-derived foods, and this occurs in the face of an anti-Neu5Gc “xeno-autoantibody” response.
Shengshu Huang, Chen, Xi, Rachel E. Taylor, Sorensen, Ricardo U, Gregg, Christopher J, Ricardo U. Sorensen, Vered Padler-Karavani, Hai Yu, Xi Chen, Varki, Ajit, Taylor, Rachel E, Yu, Hai, Darius Ghaderi, Victor Nizet, Ghaderi, Darius, Jaime Inostroza, Inostroza, Jaime, Ajit Varki, Huang, Shengshu, Christopher J. Gregg, Nizet, Victor, Padler-Karavani, Vered   +21 more
core   +1 more source

Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies [PDF]

, 2019
Sialic acids (Sias) cover vertebrate cell surface glycans. N-Acetylneuraminic acid (Neu5Ac) and its hydroxylated form N-glycolylneuraminic acid (Neu5Gc) are common Sia in mammals.
Chen, Xi, Christoph Schneider, Vered Padler-Karavani (375363), Hai Yu, Vered Padler-Karavani, Schneider, Christoph, Xi Chen, Stephan von Gunten, Xi Chen (35903), Leviatan Ben-Arye, Shani, Yu, Hai, Salam Bashir, Shani Leviatan Ben-Arye, Bashir, Salam, Hai Yu (366836), Stephan von Gunten (340797), Shani Leviatan Ben-Arye (6440699), Ben-Arye, Shani Leviatan, Christoph Schneider (413360), Salam Bashir (6631076), von Gunten, Stephan, Padler-Karavani, Vered   +21 more
core   +3 more sources

Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6

Frontiers in Medicine, 2021
Adeno-associated virus (AAV) vectors are promising candidates for gene therapy. However, a number of recent preclinical large animal studies failed to translate into the clinic. This illustrates the formidable challenge of choosing the animal models that
Estrella Lopez-Gordo, Alejandro Orlowski, Arthur Wang, Alan Weinberg, Susmita Sahoo, Thomas Weber, Thomas Weber   +6 more
doaj   +1 more source