Results 21 to 30 of about 15,627,773 (170)

Species-specific N-glycan patterns in animal and human breast milk samples [PDF]

Frontiers in Nutrition
The main components of milk are protein, fat and carbohydrates. Glycans are complex carbohydrate structures covalently bound to proteins and lipids or exist freely in solutions.
Davide Ret, Davide Ret, Salvatore Alessio Gentile, Johanna Rohrhofer, Larissa Koidl, Francesca Cozzi, Eva Untersmayr   +6 more
doaj   +2 more sources

Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat [PDF]

Molecules
This study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and ...
Michela Contò, Maria Miarelli, Sabrina Di Giovanni, Sebastiana Failla   +3 more
doaj   +2 more sources

Aptamer-CRISPR/Cas12a-Based Lateral Flow Technique for Visualized Rapid Detection of Endogenous Damage Factor Neu5Gc in Red Meat [PDF]

Foods
The N-glycolylneuraminic acid (Neu5Gc), a major salivary acid molecule found on the cell surface of animals such as pigs, cows, and sheep, can be metabolically incorporated into the body through consumption of animal-derived foods like red meat.
Yuxi Guo, Honglin Ren, Han Wang, Xuepeng Duan, Shuaihao Qi, Xi Yang, Chunyi Shangguan, Haosong Li, Yansong Li, Pan Hu, Qiang Lu, Shiying Lu   +11 more
doaj   +2 more sources

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. [PDF]

PLoS ONE, 2009
BackgroundHumans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids ...
Sandra L Diaz, Vered Padler-Karavani, Darius Ghaderi, Nancy Hurtado-Ziola, Hai Yu, Xi Chen, Els C M Brinkman-Van der Linden, Ajit Varki, Nissi M Varki   +8 more
doaj   +2 more sources

Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans—An Evolutionary Perspective [PDF]

Frontiers in Immunology, 2019
The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Meghan O. Altman, Pascal Gagneux, Pascal Gagneux   +2 more
doaj   +2 more sources

Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution [PDF]

Inflammation and Regeneration
During human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was
Yuxin Liu, Jinhong Li, Qicai Liu
doaj   +2 more sources

Generation of Cloned Sheep Lacking Galactose-α1,3-Galactose and N-Glycolylneuraminic Acid Antigens. [PDF]

Xenotransplantation
ABSTRACT Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation ...
Appleby SJ, Fermin LM, McLean ZL, Delaney S, Wagner S, Genova CD, Wei J, Meng F, Wells DN, Oback B.   +9 more
europepmc   +2 more sources

An Overview of the Importance and Value of Porcine Species in Sialic Acid Research

Biology, 2022
Humans frequently interact with pigs, whose meat is also one of the primary sources of animal protein. They are one of the main species at the center of sialic acid (Sia) research.
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source

Porcine Expanded Potential Stem Cells as a Versatile Platform for Multiplex Genome Editing and Immunophenotyping in Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Xenotransplantation utilizing pig donors offers a promising solution to organ shortages, but immune incompatibilities across species remain a major challenge. Current reliance on porcine primary fibroblasts for genome editing is limited by low inefficiency in complex gene editing and difficulties in immunophenotyping edited cells.
Xuan Y, Xiang Y, Wang X, Petersen B, Liu P.   +4 more
europepmc   +2 more sources

Xenotransplantation of the Porcine Lung-From Immunological Barriers to Emerging Experimental Strategies. [PDF]

Xenotransplantation
ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Roters N, Varma N, Ramm R, Niemann H, Zardo P, Ruhparwar A, Goecke T.   +6 more
europepmc   +2 more sources