Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells
Frontiers in Molecular Biosciences, 2022 N-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5′-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is ...
Wenqian Yang +4 more
doaj +1 more source
Pathogens, 2023 Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine’s N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Oluwamayowa Joshua Ogun +2 more
doaj +1 more source
N-glycolyl chondroitin synthesis using metabolically engineered E. coli
AMB Express, 2020 N-glycolyl chondroitin (Gc-CN) is a metabolite of N -glycolylneuraminic acid (Neu5Gc), a sialic acid that is commonly found in mammals, but not humans. Humans can incorporate exogenous Neu5Gc into their tissues from eating red meat.
Adeola E. Awofiranye +7 more
doaj +1 more source
Detection of the dietary xenoglycan N-glycolylneuraminic acid (Neu5Gc) and anti-Neu5Gc antibodies within reproductive tracts of male and female infertility subjects [PDF]
Clinical Obstetrics, Gynecology and Reproductive Medicine, 2015 Objective: To assess the frequency of dietary xenoglycanNeu5Gc and antibodies in males and females and its impact on fertility. Design: Prospective study of semen, uterine lavage, and follicular fluid from subjects undergoing infertility evaluation or in vitro fertilization (IVF) and fertile controls.
Sroga, Julie M. +9 more
openaire +3 more sources
Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis [PDF]
, 2018 BACKGROUND: Childhood exposure to a farm environment has been shown to protect against the development of inflammatory diseases, such as allergy, asthma, and inflammatory bowel disease.
Smolinska S +35 more
core +6 more sources
Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant [PDF]
, 2019 N-Glycolylneuraminic acid (Neu5Gc) is a common cell surface ligand in animals which is not biosynthesized in humans but can be acquired in human tissue from dietary sources such as red meat. It is important to understand the relevance of this potentially
Van Munster J. M. +23 more
core +1 more source
Pathogens, 2023 The sugar molecule N-glycolylneuraminic acid (Neu5Gc) is one of the most common sialic acids discovered in mammals. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) catalyses the conversion of N-acetylneuraminic acid (Neu5Ac) to Neu5Gc ...
Oluwamayowa Joshua Ogun +3 more
doaj +1 more source
Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid [PDF]
, 2013 Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes.
Löfling, Jonas +7 more
core +1 more source
Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. [PDF]
PLoS Pathogens, 2018 While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V.
Frederico Alisson-Silva +10 more
doaj +1 more source
, 2022 N-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5′-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is ...
Zhixin Tian (1867531) +4 more
core +1 more source