Results 1 to 10 of about 15,627,773 (170)

Sialic acids Neu5Ac and KDN in adipose tissue samples from individuals following habitual vegetarian or non-vegetarian dietary patterns

Scientific Reports, 2023
Sialic acids (Sias) are a class of sugar molecules with a parent nine-carbon neuraminic acid, generally present at the ends of carbohydrate chains, either attached to cellular surfaces or as secreted glycoconjugates.
Gerardo N. Guerrero-Flores, Fabio J. Pacheco, Danilo S. Boskovic, Sandaly O. S. Pacheco, Guangyu Zhang, Gary E. Fraser, Fayth L. Miles   +6 more
doaj   +1 more source

Assessment of Sialic Acid Content in Dairy Products from Buffalo’s and Goat’s Milk Compared to Cow’s Milk

Dairy
Sialic acids (SIAs) are bioactive compounds present in glycoproteins and glycolipids, playing key roles in human physiology. N-acetylneuraminic acid (Neu5Ac), the only sialic acid synthesized by humans, contributes to neurodevelopment and immune function,
Simona Rinaldi, Michela Contò, Carlo Boselli, Giuliano Palocci, Angelo Citro, Sebastiana Failla   +5 more
doaj   +1 more source

A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification

Frontiers in Molecular Biosciences
Despite an array of hypothesised implications for health, disease, and therapeutic development, antibodies against the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) remain a subject of much debate.
Esme Hutton, Esme Hutton, Emma Scott, Craig N. Robson, Nathalie Signoret, Martin A. Fascione   +5 more
doaj   +1 more source

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk.

PLoS ONE, 2018
BackgroundN-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki   +15 more
doaj   +1 more source

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

Frontiers in Chemistry, 2018
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic acid ...
Rachel A. North, Rachel A. North, Rachel A. North, Weixiao Y. Wahlgren, Weixiao Y. Wahlgren, Daniela M. Remus, Daniela M. Remus, Mariafrancesca Scalise, Sarah A. Kessans, Sarah A. Kessans, Elin Dunevall, Elin Claesson, Tatiana P. Soares da Costa, Matthew A. Perugini, S. Ramaswamy, Jane R. Allison, Jane R. Allison, Jane R. Allison, Cesare Indiveri, Rosmarie Friemann, Rosmarie Friemann, Renwick C. J. Dobson, Renwick C. J. Dobson   +22 more
doaj   +1 more source

The determination of n-acetylneuraminic acid (neu5ac) and n-glycolyl-neuraminic acid (neu5gc) types of sialic acids in hematopoietic organ of the silkworm, bombyx mori l. (lepidoptera: bombycidae)

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2012
In insects, for a long time, it was generally accepted that members of insect do not have sialic acids which are typical terminal glycans of cells surface glycolipids and glycoproteins, and thus especially important in cell interactions and signaling events.
Izzetoglu, Savas, Karacali, Sabire
openaire   +3 more sources

Characterization of an Aptamer Targeting Neu5Gc, as an Endogenous Pathogenic Factor Derived from Red Meat

Molecules
N-glycolylneuraminic acid (Neu5Gc), a sialic acid predominantly found in the non-neurohumoral fluids of hind-mouthed animals, is incapable of synthesizing Neu5Gc due to a deletion in the CMAH exon of the gene encoding human CMP-Neu5Gc hydroxylase.
Yuxi Guo, Honglin Ren, Han Wang, Yiran Xiao, Cong Wang, Mengdi Liu, Fuchun Duan, Haosong Li, Pan Hu, Yansong Li, Zengshan Liu, Shiying Lu   +11 more
doaj   +1 more source

Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) associated with the erythrocyte antigens in dogs

Canine Genetics and Epidemiology, 2019
Background N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene.
Yumiko Uno, Shota Kawakami, Kazuhiko Ochiai, Toshinori Omi   +3 more
doaj   +1 more source

Screening and Characterization of Sialic Acid-Binding Variable Lymphocyte Receptors from Hagfish

BioTech
Sialic acid is a diverse group of monosaccharides often found on the termini of N- and O-linked glycans as well as being components of glycoconjugates.
Mark Rickard N. Angelia, Abigail Joy D. Rodelas-Angelia, Cheolung Yang, Sojeong Park, Seung pyo Jeong, Hyeok Jang, Dennis Berbulla Bela-ong, Hobin Jang, Kim D. Thompson, Taesung Jung   +9 more
doaj   +1 more source

Changes in the Serum and Tissue Levels of Free and Conjugated Sialic Acids, Neu5Ac, Neu5Gc, and KDN in Mice after the Oral Administration of Edible Bird’s Nests: An LC–MS/MS Quantitative Analysis

Separations
Edible bird’s nests have a variety of biological activities, the main components of which are sialic acids. Sialic acids are a group of nine-carbon N-acetylated derivatives of neuraminic acid containing a keto group at position C2 and play important ...
Meng-Hua Wang, Zhi-Fan Wang, Man Yuan, Chun-Guo Yang, Dong-Liang Wang, Shu-Qi Wang   +5 more
doaj   +1 more source