Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides [PDF]
Frontiers in Immunology, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Anoopjit Singh Kooner, Hai Yu, Xi Chen
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N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH) [PDF]
Frontiers in Immunology, 2019 The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group ...
Andrea Perota +2 more
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The Structural Complexity and Animal Tissue Distribution of N-Glycolylneuraminic Acid (Neu5Gc)-Terminated Glycans. Implications for Their Immunogenicity in Clinical Xenografting [PDF]
Frontiers in Molecular Biosciences, 2019 N-Glycolylneuraminic acid (Neu5Gc)-terminated glycans are present in all animal cells/tissues that are already used in the clinic such as bioprosthetic heart valves (BHV) as well as in those that potentially will be xenografted in the future to overcome ...
Michael E. Breimer, Jan Holgersson
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A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle. [PDF]
PLoS ONE, 2014 The expression of N-glycolylneuraminic acid (Neu5Gc) and the cytotoxic T cell (CT) carbohydrate can impact the severity of muscular dystrophy arising from the loss of dystrophin in mdx mice.
Paul T Martin +8 more
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The Role of Non-Human Sialic Acid Neu5Gc-Containing Glycoconjugates in Human Tumors: A Review of Clinical and Experimental Evidence [PDF]
BiomoleculesN-Glycolylneuraminic acid (Neu5Gc) is a sialic acid variant commonly found in most mammals but not synthesized by humans due to an inactivating mutation in the CMP-Neu5Ac hydroxylase (CMAH) gene. Despite this, Neu5Gc-containing molecules are consistently
Rancés Blanco, Juan P. Muñoz
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N-glycolylneuraminic acid as a carbohydrate cancer biomarker
Translational Oncology, 2023 One of the forms of aberrant glycosylation in human tumors is the expression of N-glycolylneuraminic acid (Neu5Gc). The only known enzyme to biosynthesize Neu5Gc in mammals, cytidine-5′-monophosphate-N-acetylneuraminic acid (CMAH), appears to be ...
Jing Wang +3 more
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Generation of Cloned Sheep Lacking Galactose-α1,3-Galactose and N-Glycolylneuraminic Acid Antigens. [PDF]
XenotransplantationABSTRACT Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation ...
Appleby SJ +9 more
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Aptamer-CRISPR/Cas12a-Based Lateral Flow Technique for Visualized Rapid Detection of Endogenous Damage Factor Neu5Gc in Red Meat [PDF]
FoodsThe N-glycolylneuraminic acid (Neu5Gc), a major salivary acid molecule found on the cell surface of animals such as pigs, cows, and sheep, can be metabolically incorporated into the body through consumption of animal-derived foods like red meat.
Yuxi Guo +11 more
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Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat [PDF]
MoleculesThis study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and ...
Michela Contò +3 more
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Species-specific N-glycan patterns in animal and human breast milk samples [PDF]
Frontiers in NutritionThe main components of milk are protein, fat and carbohydrates. Glycans are complex carbohydrate structures covalently bound to proteins and lipids or exist freely in solutions.
Davide Ret +6 more
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