Results 11 to 20 of about 15,524,867 (163)

N-Glycolylneuraminic Acid in Animal Models for Human Influenza A Virus [PDF]

Viruses, 2021
The first step in influenza virus infection is the binding of hemagglutinin to sialic acid-containing glycans present on the cell surface. Over 50 different sialic acid modifications are known, of which N-acetylneuraminic acid (Neu5Ac) and N ...
Cindy M. Spruit, Nikoloz Nemanichvili, Masatoshi Okamatsu, Hiromu Takematsu, Geert-Jan Boons, Robert P. de Vries   +5 more
doaj   +5 more sources

Preferential Accumulation of 14C-N-Glycolylneuraminic Acid over 14C-N-Acetylneuraminic Acid in the Rat Brain after Tail Vein Injection. [PDF]

PLoS ONE, 2015
The two main molecular species of sialic acid existing in nature are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Neu5Ac is abundant in mammalian brains and plays crucial roles in many neural functions.
Risa Taguchi, Akira Minami, Yukino Matsuda, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki   +6 more
doaj   +2 more sources

N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease [PDF]

BMC Cancer, 2022
Background Normal human tissues do not express glycans terminating with the sialic acid N-glycolylneuraminic acid (Neu5Gc), yet Neu5Gc-containing glycans have been consistently found in human tumor tissues, cells and secretions and have been proposed as ...
Lucy K. Shewell, Christopher J. Day, Jamie R. Kutasovic, Jodie L. Abrahams, Jing Wang, Jessica Poole, Colleen Niland, Kaltin Ferguson, Jodi M. Saunus, Sunil R. Lakhani, Mark von Itzstein, James C. Paton, Adrienne W. Paton, Michael P. Jennings   +13 more
doaj   +3 more sources

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. [PDF]

PLoS ONE, 2009
BackgroundHumans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids ...
Sandra L Diaz, Vered Padler-Karavani, Darius Ghaderi, Nancy Hurtado-Ziola, Hai Yu, Xi Chen, Els C M Brinkman-Van der Linden, Ajit Varki, Nissi M Varki   +8 more
doaj   +2 more sources

Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans—An Evolutionary Perspective [PDF]

Frontiers in Immunology, 2019
The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Meghan O. Altman, Pascal Gagneux, Pascal Gagneux   +2 more
doaj   +2 more sources

Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution [PDF]

Inflammation and Regeneration
During human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was
Yuxin Liu, Jinhong Li, Qicai Liu
doaj   +2 more sources

Analysis on the terahertz spectral characteristics of two types of sialic acids in solid state and aqueous solution [PDF]

Scientific Reports
In this study, N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) were chosen as representative sialic acids to study their terahertz (THz) spectral characteristics in solid and aqueous states.
Zhuang Peng, Yang Gao, Xinrui Zhang, Huiyu Yang, Bo Su, Kai Li, Cunlin Zhang   +6 more
doaj   +2 more sources

Generation of Cloned Sheep Lacking Galactose-α1,3-Galactose and N-Glycolylneuraminic Acid Antigens. [PDF]

Xenotransplantation
ABSTRACT Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation ...
Appleby SJ, Fermin LM, McLean ZL, Delaney S, Wagner S, Genova CD, Wei J, Meng F, Wells DN, Oback B.   +9 more
europepmc   +2 more sources

Porcine Expanded Potential Stem Cells as a Versatile Platform for Multiplex Genome Editing and Immunophenotyping in Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Xenotransplantation utilizing pig donors offers a promising solution to organ shortages, but immune incompatibilities across species remain a major challenge. Current reliance on porcine primary fibroblasts for genome editing is limited by low inefficiency in complex gene editing and difficulties in immunophenotyping edited cells.
Xuan Y, Xiang Y, Wang X, Petersen B, Liu P.   +4 more
europepmc   +2 more sources

An Overview of the Importance and Value of Porcine Species in Sialic Acid Research

Biology, 2022
Humans frequently interact with pigs, whose meat is also one of the primary sources of animal protein. They are one of the main species at the center of sialic acid (Sia) research.
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source