Results 41 to 50 of about 15,627,774 (168)

Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid [PDF]

, 2013
Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes.
Löfling, Jonas, Parrish, Colin R., Sangbom Michael Lyi, Colin R Parrish, Ajit Varki, Lyi, Sangbom Michael, Varki, Ajit, Jonas Löfling   +7 more
core   +1 more source

DataSheet1_Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells.docx

, 2022
N-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5′-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is ...
Zhixin Tian (1867531), Zhigang Cheng (647368), Qulian Guo (146481), Wenqian Yang (1947496), Yuan Jiang (296541)   +4 more
core   +1 more source

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. [PDF]

PLoS Pathogens, 2018
While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V.
Frederico Alisson-Silva, Janet Z Liu, Sandra L Diaz, Lingquan Deng, Mélanie G Gareau, Ronald Marchelletta, Xi Chen, Victor Nizet, Nissi Varki, Kim E Barrett, Ajit Varki   +10 more
doaj   +1 more source

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway

Toxins, 2023
N-glycolylneuraminic acid (Neu5Gc) is a specific factor in red meat that induces intestinal disease. Our aim was to investigate the effect of Neu5Gc on the intestinal barrier as well as its mechanism of endocytosis and exocytosis. Ten specific inhibitors
Enqi He, Wei Quan, Jie Luo, Chuxin Liu, Wanting Zheng, Qingwu Shen   +5 more
doaj   +1 more source

Exposure of Children to Rural Lifestyle Factors Associated With Protection Against Allergies Induces an Anti-Neu5Gc Antibody Response

Frontiers in Immunology, 2019
Rural lifestyle has been shown to be highly protective against the development of allergies. Contact to farm-animals or pets and early-life consumption of milk products turned out to be important.
Remo Frei, Remo Frei, Caroline Roduit, Caroline Roduit, Caroline Roduit, Ruth Ferstl, Ruth Ferstl, Liam O'Mahony, Roger P. Lauener, Roger P. Lauener   +9 more
doaj   +1 more source

Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid

Frontiers in Immunology, 2020
The emerging field of biotherapeutics provides successful treatments for various diseases, yet immunogenicity and limited efficacy remain major concerns for many products.
Sharon Yehuda, Vered Padler-Karavani
doaj   +1 more source

Electrochemical Evaluation of Tumor Development via Cellular Interface Supported CRISPR/Cas Trans-Cleavage

Research, 2022
Evaluating tumor development is of great importance for clinic treatment and therapy. It has been known that the amounts of sialic acids on tumor cell membrane surface are closely associated with the degree of cancerization of the cell. So, in this work,
Liangfen Cheng, Fuhan Yang, Longfei Tang, Lelin Qian, Xu Chen, Feng Guan, Juan Zhang, Genxi Li   +7 more
doaj   +1 more source

Structure aided design of a Neu5Gc specific lectin

Scientific Reports, 2017
Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2–3-linked N-glycolylneuraminic acid (Neu5Gc).
Christopher J. Day, Adrienne W. Paton, Melanie A. Higgins, Lucy K. Shewell, Freda E.-C. Jen, Benjamin L. Schulz, Brock P. Herdman, James C. Paton, Michael P. Jennings   +8 more
doaj   +1 more source

Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah(−/−)mdx Mice [PDF]

, 2021
Humans cannot synthesize the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an inactivating deletion in the cytidine-5'-monophospho-(CMP)–N-acetylneuraminic acid hydroxylase (CMAH) gene responsible for its synthesis.
Martin, Paul T, Ashbrook, Anna, Maki, Agatha, Chen, Xi, Varki, Ajit, Golden, Bethannie, Okerblom, Jonathan, Janssen, Paul M.L., Crowe, Kelly E, Janssen, Paul ML, Yu, Hai, Diaz, Sandra, Crowe, Kelly E., Samraj, Annie, Kawanishi, Kunio, Zygmunt, Deborah A, Zygmunt, Deborah A., Martin, Paul T.   +17 more
core   +1 more source

Theoretical Studies on the Electronic Structure Parameters and Reactive Activity of Neu5Gc and Neu5Ac under Food Processing Solvent Environment

Molecules, 2019
The animal product hazard factor N-glycolylneuraminic (Neu5Gc) and brain nutrient substance N-acetylneuraminic acid (Neu5Ac) were studied at the M062X/6-311 + G(d,p) geometry optimization level.
Rui Chang, Bowen Yang, Qiu-Jin Zhu
doaj   +1 more source