Results 81 to 90 of about 15,627,773 (170)
, 2020 Within the different structural sugar components of glycoconjugates, one sugar family confers to the animal kingdom a special resistance to pathogens like viruses, bacteria, fungi or parasites. This sugar family is called sialic acid and is composed of a
Gasparotto, Erika +5 more
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Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley +1 more source
, 2017 Aim: Recombinant glycoprotein produced in nonhuman mammalian cell lines can be modified with the immunogenic nonhuman sialic N-glycolylneuraminic acid (Neu5Gc).
Heinrich Faust +5 more
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Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS. [PDF]
, 2020 OBJECTIVE To explore the repertoire of glycan-specific immunoglobulin G (IgG) antibodies in treatment-naive patients with relapsing-remitting multiple sclerosis (RRMS). METHODS A systems-level approach combined with glycan array technologies was
Keller, Christian W +10 more
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, 2017 A series of novel sialoglycopolypeptides carrying N-glycolylneuraminic acid (Neu5Gc)-containing trisaccharides having α(2 → 3)- and α(2 → 6)-linkages in the side chains of γ-polyglutamic acid (γ-PGA) were designed as competitive inhibitors against equine
Ami Koizumi +9 more
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Absorption, metabolic incorporation, and inflammation engendered by the non-human sialic acid, N- glycolylneuraminic acid [PDF]
, 2011 All human adults have circulating antibodies against N- glycolylneuraminic acid (Neu5Gc), a sialic acid that can't be produced in humans. However, dietary Neu5Gc (particularly from red meat) can be metabolically incorporated into human tissues and ...
Gregg, Christopher John
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Possible Role of Dietary N-glycolyneuraminic Acid and Dysbiosis in Canine Enteropathy Pathogenesis [PDF]
N-glycolylneuraminic acid (Neu5Gc) is synthesized from its N-acetyl precursor (Neu5Ac) by cytidine-50- monophospho-N acetylneuraminic acid hydroxylase (CMAH). Absent in humans and ferrets, it is polymorphic in dogs.
Alessandra Gavazza +10 more
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, 2009 Background: Humans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and ...
Nancy Hurtado-Ziola +8 more
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Progress in Studies on Relationship between Red Meat Intake, N-Glycolylneuraminic Acid and Cancer Risk [PDF]
, 2014 世界癌症研究基金会报告指出,过多摄入红肉会增加患癌症的风险,红肉可能是导致某些癌症的原因之一。有研究得出,摄入红肉后身体内产生的一种唾液酸——n-羟乙酰神经氨酸(n-glyCOlylnEurAMInIC ACId,nEu5gC)可能与癌症的发生有关。本文从红肉与癌的关系,引出对nEu5gC的讨论,从它的结构、来源、生理功能到临床应用价值,最后是与癌症可能的机制讨论,并重申它的研究价值。According to the World Cancer Research Fund, excessive ...
李红卫, 范杏丹
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