Results 91 to 100 of about 15,627,773 (170)

Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation

, 2013
Clinical xenotransplantation is not possible because humans possess antibodies that recognize antigens on the surface of pig cells. Galα-1,3-Gal (Gal) and N-glycolylneuraminic acid (Neu5Gc) are two known xenoantigens.
Paris, Leela L, Chihara, Ray K, Tector, A Joseph, Sidner, Richard A, Reyes, Luz M, Ivary, Bess, Burlak, Christopher, Downey, Susan M, Li, Ping, Yin, Fuqin, Lutz, Andrew J, Blankenship, Ross L, Wang, Zheng-Yu, Estrada, Jose L   +13 more
core   +1 more source

Scheme for hydrolytic cleavage of terminal sialic acid and its labeling for fluorescence detection.

, 2018
DMB: 1,2-diamino-4,5-methylenedioxybenzene, Neu5Ac: N-acetylneuraminic acid, Neu5Gc: N-glycolylneuraminic acid.
Hiroshi Hinou (1466248), Ibrahim F. Rehan (6162977), Daniel Seifu Melka (6162971), Shobith Rangappa (773465), Shin-Ichiro Nishimura (81709), Yimenashu Mamo Kassaye (6162974), Abrha G. Gebrehiwot (6162968), Toshiya Kamiyama (6162980)   +7 more
core   +1 more source

The avian influenza A virus receptor SA-α2,3-Gal is expressed in the porcine nasal mucosa sustaining the pig as a mixing vessel for new influenza viruses

Virus Research
Influenza A viruses (IAVs) originate from wild birds but have on several occasions jumped host barriers and are now also circulating in humans and mammals.
Charlotte Kristensen, Lars E. Larsen, Ramona Trebbien, Henrik E. Jensen   +3 more
doaj   +1 more source

Analysis of sulfated sialic acids by liquid chromatography coupled with high-resolution mass spectrometry and fluorescence detection

BBA Advances
Sialic acid is localized at the outermost glycan, and involved in regulatory roles as one of the most important glycotopes in various biological phenomena. Recently, we established a highly sensitive and selective method for the fine differentiation of 1,
Sota Yamashita, Takayuki Omoto, Nao Yamakawa, Naoko Komura, Hiromune Ando, Di Wu, Ken Kitajima, Masaya Hane, Chihiro Sato   +8 more
doaj   +1 more source

Evidence of free radical participation in N-glycolylneuraminic acid generation in liver of chicken treated with gallotannic acid

, 2004
20-28The occurrence of N-glycolylneuraminic acid (Neu5Gc) in cancerous tissue and inflammatory diseases, conditions associated with increased oxidative stress suggests the participation of reactive oxygen radicals in Neu5Gc generation, where an oxygen ...
Bansal, Devi D, Mwangi, Danny W
core  

Human antibody reactivity against xenogeneic N-glycolylneuraminic acid and galactose-α-1,3-galactose antigen.

, 2018
BackgroundDespite the development of 1,3-galactosyl transferase-knockout (GTKO) pigs, acute humoral xenograft rejection caused by antibodies against non-Gal antigens, along with complement activation, are hurdles that need to be overcome.
Cho, Bumrae, Hurh, S, Kang, Bohae, Lee, Eun Mi, Yang, Jaeseok, Ahn, Curie, Chung, Yun Shin, Choi, Inho, Jeong, Jong Cheol, Kim, Young June, Kim, Hwajung, Hwang, Jong-Ik, Surh, CD, Kim, Jae Young, Lee, Byeong Chun   +14 more
core   +1 more source

N-Glycolylneuraminic acid conjugates: Implications of their absence in mammalian biochemistry

, 2003
217-225N-glycolylneuraminic acid (Neu5Gc) is one of the two most common forms of sialic acids present in glycoproteins and glycolipids of mammalian tissues.
Mwangi, Daniel W, Bansal, Devi D
core  

Development of a Matrix-Matched Calibration Curve for Multi-Site Quantification of Neu5Gc-Bearing N-Glycans

N -glycolylneuraminic acid (Neu5Gc) has been repeatedly associated with human cancer, but reliable detection has remained elusive, generating controversy regarding its presence in human samples.
Nicholas J DeBono, Daniel Kolarich, Michael P. Jennings, Christopher Ashwood, Jessica Poole, Christopher J Day, Edward S. X. Moh, Nicolle H. Packer   +7 more
core   +1 more source

Qualitative Characterization of Neu5Gc-Containing N-Glycans in Commercial Cheddar Cheese Products Using Nano-UHPLC-ESI-MS/MS-A Pilot Study. [PDF]

Int J Mol Sci
Mogut D, Goli M, Reyes CDG, Mechref Y, Iwaniak A.   +4 more
europepmc   +1 more source

Neu5Gc-associated Serum Immunoglobulin G Glycosylation as a Diagnostic Biomarker for Hepatocellular Carcinoma. [PDF]

J Clin Transl Hepatol
Cao X, Lu X, Li Q, Lu J, Song X, Han Y, Pu C, Pang Y.   +7 more
europepmc   +1 more source