Results 101 to 110 of about 3,818 (198)

Assessment of Sialic Acid Content in Dairy Products from Buffalo’s and Goat’s Milk Compared to Cow’s Milk

Dairy
Sialic acids (SIAs) are bioactive compounds present in glycoproteins and glycolipids, playing key roles in human physiology. N-acetylneuraminic acid (Neu5Ac), the only sialic acid synthesized by humans, contributes to neurodevelopment and immune function,
Simona Rinaldi, Michela Contò, Carlo Boselli, Giuliano Palocci, Angelo Citro, Sebastiana Failla   +5 more
doaj   +1 more source

Silencing porcine CMAH and GGTA1 genes significantly reduces xenogeneic consumption of human platelets by porcine livers [PDF]

, 2016
BACKGROUND: A profound thrombocytopenia limits hepatic xenotransplantation in the pig-to-primate model. Porcine livers also have shown the ability to phagocytose human platelets in the absence of immune-mediated injury.
Blankenship, Ross L., Butler, James R., Estrada, Jose L., Ladowski, Joeseph M., Li, Ping, Martens, Gregory R., Paris, Leela L., Sidner, Richard A., Tector, A. Joseph, Tector, Matthew   +9 more
core   +1 more source

Studying the interaction of glycans with intact virions and virus‐like particles by ligand‐observed NMR spectroscopy

Magnetic Resonance in Chemistry, Volume 62, Issue 5, Page 337-344, May 2024.
▪ Abstract Virus‐glycan interactions play a crucial role in the infection process of many viruses. NMR spectroscopy has emerged as a powerful tool for studying these interactions at the molecular level. In this article, we review several published papers and reports that have highlighted the application of NMR spectroscopy in understanding the complex ...
Thomas Haselhorst
wiley   +1 more source

Anti‐pig antibodies in swine veterinarian serum: Implications for clinical xenotransplantation

Xenotransplantation, Volume 31, Issue 3, May/June 2024.
Abstract Recent clinical xenotransplantation and human decedent studies demonstrate that clinical hyperacute rejection of genetically engineered porcine organs can be reliably avoided but that antibody mediated rejection (AMR) continues to limit graft survival.
Guerard W. Byrne, Christopher G. A. McGregor   +1 more
wiley   +1 more source

Sialic acids in biological and therapeutic processes: opportunities and challenges [PDF]

, 2015
It is now well documented that carbohydrates play multiple roles in biological processes, and hence are interesting targets for chemical biology and medicinal chemistry programmes.
Helen MI Osborn, Julia Bauer, Varki A, Zeichner SB   +3 more
core   +1 more source

Intestine specific regulation of pig cytidine-5′-monophospho-N-acetylneuraminic acid hydroxylase gene for N-glycolylneuraminic acid biosynthesis

Scientific Reports, 2019
N-glycolylneuraminic acid (Neu5Gc), a generic form of sialic acid, is enzymatically synthesized by cytidine-5′-monophospho-N-acetylneuraminic acid hydroxylase (CMAH).
Kwon-Ho Song, Choong‐Hwan Kwak, Tae-Wook Chung, Sun‐Hyung Ha, Junyoung Park, Ki-Tae Ha, Seung-Hak Cho, Young-Choon Lee, Cheorl-Ho Kim   +8 more
semanticscholar   +1 more source

Comparison of separation techniques for the elucidation of IgG N-glycans pooled from healthy mammalian species [PDF]

, 2014
The IgG N-glycome provides sufficient complexity and information content to serve as an excellent source for biomarker discovery in mammalian health.
Adamczyk, Barbara, Guttman, András, Karlsson, Niclas G., Kelly, Ronan M., Rudd, Pauline M., Schomberg, Michael, Szekrényes, Ákos, Tharmalingam-Jaikaran, Tharmala   +7 more
core   +1 more source

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid [PDF]

, 2010
The nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) is metabolically incorporated into human tissues from certain mammalian-derived foods, and this occurs in the face of an anti-Neu5Gc “xeno-autoantibody” response.
Ajit Varki, Allen, Anderson, Angata, Bardor, Bouchet, Campagnari, Cariappa, Carlin, Chen, Chou, Christopher J. Gregg, Cober, Corfield, Darius Ghaderi, Diaz, Estabrook, Faden, Fagarasan, Galili, Greiner, Hai Yu, Hedlund, Hedlund, Hood, Houliston, Irie, Jaime Inostroza, Jones, Jurcisek, Lewis, Litinskiy, Mandrell, Manzi, Mattos-Guaraldi, Morell, Naito, Nguyen, Nizet, Ochsenbein, Padler-Karavani, Peng, Pham, Posekany, Rachel E. Taylor, Ram, Ricardo U. Sorensen, Schauer, Schilling, Severi, Shengshu Huang, Soto, Springer, Tahara, Tangvoranuntakul, Traving, Turk, Ueda, Van Lenten, Varki, Vered Padler-Karavani, Victor Nizet, Vimr, Vimr, Vives, Xi Chen, Yin, Yu, Zeleny, Zhu, Zola   +70 more
core   +3 more sources

Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches [PDF]

, 2013
Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the complex ...
Daniotti, Jose Luis, Rodríguez Walker, Macarena, Ruggiero, Fernando Miguel, Torres Demichelis, Vanina Andrea, Vilcaes, Aldo Alejandro   +4 more
core   +2 more sources

The determination of n-acetylneuraminic acid (neu5ac) and n-glycolyl-neuraminic acid (neu5gc) types of sialic acids in hematopoietic organ of the silkworm, bombyx mori l. (lepidoptera: bombycidae)

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2012
In insects, for a long time, it was generally accepted that members of insect do not have sialic acids which are typical terminal glycans of cells surface glycolipids and glycoproteins, and thus especially important in cell interactions and signaling events.
Izzetoglu, Savas, Karacali, Sabire
openaire   +3 more sources