Results 111 to 120 of about 3,818 (198)

Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis [PDF]

, 2018
BACKGROUND: Childhood exposure to a farm environment has been shown to protect against the development of inflammatory diseases, such as allergy, asthma, and inflammatory bowel disease.
Akdis CA, Akdis M, Barcik W, Bieli C, Braun-Fahrländer C, Dalphin J-C, Depner M, Doekes G, Ferstl R, Frei R, Genuneit J, Jutel M, Karvonen AM, Konieczna P, Lauener RP, Loeliger S, Nehrbass D, O'Mahony L, Pekkanen J, Pershagen G, Prevention of Allergy Risk factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle (PARSIFAL) study group, Protection Against Allergy Study in Rural Environments (PASTURE)/Mechanisms of Early Protective Exposures on Allergy Development (EFRAIM) study group, Pugin B, Renz H, Riedler J, Rodriguez-Perez N, Roduit C, Schaub B, Schiavi E, Smolinska S, van Hage M, von Mutius E, Waser M, Wawrzyniak M, Wirz OF, Ziegler M   +35 more
core   +2 more sources

ROLE OF XENOSIALIZATION IN THE PATHOGENESIS OF COLITIS IN THE CANINE MODEL: POSSIBLE POSITIVE EFFECTS OF NEW PROBIOTICS BLENDS [PDF]

, 2023
Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal inflammation with no exact known cause. In dogs, IBD is expressed histologically with lymphoplasmacytic inflammation (LPL) of gastrointestinal tract.
Alessandra, Gavazza, Barbara, Siminoati, Daniela, Olivero, Fiorella, Carnevali, Giacomo, Rossi, Ilaria, Patuzzi, Lucia, Biagini, Matteo, Cerquetella, Sara, Mangiaterra   +8 more
core  

Mechanism of Uptake and Incorporation of the Non-human Sialic Acid N-Glycolylneuraminic Acid into Human Cells*

Journal of Biological Chemistry, 2005
N-Glycolylneuraminic acid (Neu5Gc) is a widely expressed sialic acid in mammalian cells. Although humans are genetically deficient in producing Neu5Gc, small amounts are present in human cells in vivo.
M. Bardor, Dzung H. Nguyen, S. Diaz, A. Varki   +3 more
semanticscholar   +1 more source

Alpha 1,3-Galactosyltransferase Deficiency in Pigs Increases Sialyltransferase Activities That Potentially Raise Non-Gal Xenoantigenicity [PDF]

, 2011
We examined whether deficiency of the GGTA1 gene in pigs altered the expression of several glycosyltransferase genes. Real-time RT-PCR and glycosyltransferase activity showed that 2 sialyltransferases [α2,3-sialyltransferase (α2,3ST) and α2,6 ...
Cho, Ssang-Goo, Han, Jae-Woong, Kang, Min-Hui, Kim, Dong-Ku, Kim, Jin-Hoi, Kwon, Deug-Nam, Oh, Jae-Wook, Oh, Mihye, Park, Chankyu, Park, Jong-Yi, Park, Mi-Ryung, Song, Hyuk   +11 more
core   +3 more sources

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

Frontiers in Chemistry, 2018
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic acid ...
Rachel A. North, Rachel A. North, Rachel A. North, Weixiao Y. Wahlgren, Weixiao Y. Wahlgren, Daniela M. Remus, Daniela M. Remus, Mariafrancesca Scalise, Sarah A. Kessans, Sarah A. Kessans, Elin Dunevall, Elin Claesson, Tatiana P. Soares da Costa, Matthew A. Perugini, S. Ramaswamy, Jane R. Allison, Jane R. Allison, Jane R. Allison, Cesare Indiveri, Rosmarie Friemann, Rosmarie Friemann, Renwick C. J. Dobson, Renwick C. J. Dobson   +22 more
doaj   +1 more source

The Expression of PolySia/TriSia Associated Proteins and Genes on Developing Brain and the Effect of Dietary Sialic Acid Intervention in Piglets [PDF]

, 2015
摘要 研究背景：唾液酸（Sialicacid,Sia）是一类九碳单糖神经氨酸的总称，在细胞表面发挥其多种生物学功能。在体内，Sia通常以游离唾液酸、聚唾液酸（多聚/寡聚）、唾液酸衍生物（糖蛋白，糖脂）这三种形式存在。多聚唾液酸（polySialicacid,ploySia），一种唾液酸残基通过α2-8键连接而成的线性聚合物，广泛分布于在哺乳动物神经系统中，它的主要蛋白载体是神经细胞粘附因子（Neuralcelladhesionmolecule,NCAM）。PolySia-NCAM在细胞迁移、神经突生长 ...
任贺
core  

Study on the relationship between red meat, dietary Neu5Gc intake and anti-Neu5Gc antibody [PDF]

, 2015
唾液酸类化合物是以九碳糖神经氨酸(5-amino-3,5-dideoxy-D-glycero-D-galactononulsonicacid)为基本结构的一族衍生物的总称。目前，已分离和鉴定的有50余种，包括N-乙酰基神经氨酸(N-acetylneuraminicacid,Neu5Ac)、N-羟乙酰基神经氨酸(N-glycoulylneuraminicacid,Neu5Gc)和2－酮基－3－脱氧九酮糖酸(2-keto-3-deoxy-nonulosonicacid,KDN)三种核心单体 ...
范杏丹
core  

Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) associated with the erythrocyte antigens in dogs

Canine Genetics and Epidemiology, 2019
Background N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene.
Yumiko Uno, Shota Kawakami, Kazuhiko Ochiai, Toshinori Omi   +3 more
doaj   +1 more source

Phylogenetic distribution of CMP-Neu5Ac hydroxylase (CMAH), the enzyme synthetizing the pro-inflammatory human xeno-antigen Neu5Gc [PDF]

, 2018
The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for thesynthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surfaceproteins of most deuterostomes.
Peri, Sateesh
core   +1 more source

Changes in the Serum and Tissue Levels of Free and Conjugated Sialic Acids, Neu5Ac, Neu5Gc, and KDN in Mice after the Oral Administration of Edible Bird’s Nests: An LC–MS/MS Quantitative Analysis

Separations
Edible bird’s nests have a variety of biological activities, the main components of which are sialic acids. Sialic acids are a group of nine-carbon N-acetylated derivatives of neuraminic acid containing a keto group at position C2 and play important ...
Meng-Hua Wang, Zhi-Fan Wang, Man Yuan, Chun-Guo Yang, Dong-Liang Wang, Shu-Qi Wang   +5 more
doaj   +1 more source