Results 81 to 90 of about 3,818 (198)

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site [PDF]

, 2018
Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic ...
Abramson, Jeff,, Andersson, Rebecka,, Beis, Konstantinos,, Bengtsson-Palme, Johan,, Bisignano, Paola,, Caing-Carlsson, Rhawnie,, Claesson, Elin,, Dobson, Renwick C.J.,, Dunevall, Elin,, Farewell, Anne,, Friemann, Rosmarie,, Goyal, Parveen,, Grabe, Michael,, Indiveri, Cesare,, Lund University., Nilsson, Ulf J.,, North, Rachel A.,, Paz, Aviv,, Pochini, Lorena,, Ramaswamy, S.,, Scalise, Mariafrancesca,, Wahlgren, Weixiao Y.,   +21 more
core   +3 more sources

Generation of cattle knockout for galactose‐α1,3‐galactose and N‐glycolylneuraminic acid antigens

Xenotransplantation, 2019
Two well‐characterized carbohydrate epitopes are absent in humans but present in other mammals. These are galactose‐α1,3‐galactose (αGal) and N‐glycolylneuraminic acid (Neu5Gc) which are introduced by the activities of two enzymes including α(1,3 ...
A. Perota, I. Lagutina, R. Duchi, Elisa Zanfrini, G. Lazzari, Jean-Paul Judor, S. Conchon, J. Bach, T. Bottio, G. Gerosa, C. Costa, M. Galiñanes, J. Roussel, V. Padler-Karavani, E. Cozzi, J. Soulillou, C. Galli   +16 more
semanticscholar   +1 more source

The milk metabolome and its potential utilisation for enhanced dairy processing

International Journal of Dairy Technology, Volume 78, Issue 3, July–September 2025.
The milk metabolome can be affected by a variety of different intrinsic and extrinsic factors, which can subsequently affect important parameters of milk quality and processability. This review explores this relationship and provides an overview of the topic of milk metabolomics as an ever‐evolving field of study.
Paula Rojas‐Gómez, Raghunath Pariyani, Noel A McCarthy, Lorraine M Bateman, James A O'Mahony, Tom F O'Callaghan   +5 more
wiley   +1 more source

Characterization of goat colostrum oligosaccharides by nano-liquid chromatography on chip quadrupole time-of-flight mass spectrometry and hydrophilic interaction liquid chromatography-quadrupole mass spectrometry [PDF]

, 2016
A detailed qualitative and quantitative characterization of goat colostrum oligosaccharides (GCO) has been carried out for the first time. Defatted and deproteinized colostrum samples, previously treated by size exclusion chromatography (SEC) to remove ...
Barile, Daniela, Bunyatratchata, A., Clemente, Alfonso, Martín-García, I., Martín-Ortiz, Andrea, Moreno, F. Javier, Ruiz-Matute, Ana I., Salcedo, J., Sanz, M. Luz   +8 more
core   +1 more source

Clinical Xenotransplantation of Gene‐Edited Pig Organs: A Review of Experiments in Living Humans Since 2022

Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.
Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley   +1 more source

Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to cancer: French NutriNet-Santé study

BMC Medicine, 2020
Background High consumption of red and processed meat is commonly associated with increased cancer risk, particularly colorectal cancer. Antibodies against the red meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate cancer in “human ...
Salam Bashir, Leopold K. Fezeu, Shani Leviatan Ben-Arye, Sharon Yehuda, Eliran Moshe Reuven, Fabien Szabo de Edelenyi, Imen Fellah-Hebia, Thierry Le Tourneau, Berthe Marie Imbert-Marcille, Emmanuel B. Drouet, Mathilde Touvier, Jean-Christian Roussel, Hai Yu, Xi Chen, Serge Hercberg, Emanuele Cozzi, Jean-Paul Soulillou, Pilar Galan, Vered Padler-Karavani   +18 more
doaj   +1 more source

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation

mBio, 2019
Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. NTHi utilizes sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glycolipid ...
Preston S. K. Ng, Christopher J. Day, John M. Atack, Lauren E. Hartley-Tassell, Linda E. Winter, Tal Marshanski, Vered Padler-Karavani, Ajit Varki, Stephen J. Barenkamp, Michael A. Apicella, Michael P. Jennings   +10 more
doaj   +1 more source

Humoral Barrier to Preclinical and Clinical Xenotransplantation

Xenotransplantation, Volume 32, Issue 3, May/June 2025.
ABSTRACT Xenotransplantation is finally moving toward clinical application. Despite the progress in survival in preclinical models and the limited attempts at clinical heart transplantation, the initial problem of xenoreactive antibodies in human serum remains a proximal barrier to widespread success in preclinical and clinical settings.
A. Joseph Tector, Matt Tector, Sabrina Copsel, Zhang Yu Wang, Chris Burlak, Luz M. Reyes, Jose L. Estrada, Victor Novara Gennuso, Andrew B. Adams   +8 more
wiley   +1 more source

Loss of N‐glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolution

American Journal of Physical Anthropology, 2002
The surface of all mammalian cells is covered with a dense and complex array of sugar chains, which are frequently terminated by members of a family of molecules called sialic acids. One particular sialic acid called N‐glycolylneuraminic acid (Neu5Gc) is
A. Varki
semanticscholar   +1 more source