Results 121 to 130 of about 15,085,302 (278)

Inhibition of N-linked glycosylation impairs ALK phosphorylation and disrupts pro-survival signaling in neuroblastoma cell lines

BMC Cancer, 2011
Background The Anaplastic Lymphoma Kinase (ALK) is an orphan receptor tyrosine kinase, which undergoes post-translational N-linked glycosylation.
Del Grosso Federica, De Mariano Marilena, Passoni Lorena, Luksch Roberto, Tonini Gian, Longo Luca   +5 more
doaj   +1 more source

The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation [PDF]

, 2002
Mutations in the photopigment rhodopsin are the major cause of autosomal dominant retinitis pigmentosa. The majority of mutations in rhodopsin lead to misfolding of the protein.
Munro, PMG, Cheetham, ME, Saliba, RS, Luthert, PJ   +3 more
core  

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Investigation of Site-Specific Differences in Glycan Microheterogeneity by N-Glycopeptide Mapping of VEGFR-IgG Fusion Protein

Molecules, 2019
A biosimilar fusion protein VEGFR-IgG consisting of vascular endothelial growth factor receptors 1 and 2 (VEGFR-1, VEGFR-2) and the Fc portion of human IgG1 was prepared for this study.
Young Hye Hahm, Ju Yeon Lee, Yeong Hee Ahn   +2 more
doaj   +1 more source

Refining the genetics of muscular dystrophies with defective glycosylation of dystroglycan [PDF]

, 2010
The aberrant glycosylation of α-dystroglycan is associated with a subset of clinically heterogeneous muscular dystrophies collectively referred to as dystroglycanopathies.
Godfrey, C.
core  

Deep Learning Prediction of O‐Glycopeptide Tandem Mass Spectra Enhances O‐Glycoproteomics

Advanced Science, EarlyView.
DeepGPO integrates Transformer and graph neural networks with tailored training strategies, including data augmentation, loss re‐weighting, and pre‐training, to achieve high‐quality O‐glycopeptide MS/MS spectra prediction. The predicted MS/MS spectra are used to localize O‐glycosylation sites from HCD MS/MS data, enhancing O‐glycoproteomics analysis ...
Yu Zong, Yuxin Wang, Liang Qiao
wiley   +1 more source

Quantitative Analyses Reveal Novel Roles for N-Glycosylation in a Major Enteric Bacterial Pathogen

mBio, 2019
In eukaryotes, glycosylation plays a role in proteome stability, protein quality control, and modulating protein function; however, similar studies in bacteria are lacking.
Sherif Abouelhadid, Simon J. North, Paul Hitchen, Prerna Vohra, Cosmin Chintoan-Uta, Mark Stevens, Anne Dell, Jon Cuccui, Brendan W. Wren   +8 more
doaj   +1 more source

N-linked and O-linked glycosylation of the A244.AE and 6240.B gp120 proteins.

, 2018
N-linked and O-linked glycosylation sites of the A244.AE gp120 (upper panel) and 6240.B gp120 (lower panel) were identified by LC-MS/MS analysis after enzymatic deglycosylations (PNGase F, Endo H or Endo F3) and proteolytic digestions (trypsin or pepsin)
Susan Zolla-Pazner (156004), Ryan Duffy (779151), Hua-Xin Liao (161409), Susan Hilt (3149133), Christopher Hamlin (5147024), Priyanka Ramesh (1374711), Rushit Lodaya (5147000), DeeAnn Martinez-Guzman (5147021), Ning Li (45258), Xiaoying Shen (164029), Andrea Carfi (203340), Brian Burke (248053), Jerome H. Kim (132312), Nelson L. Michael (132309), William Fulp (459224), Kristian Friedrich (816041), Raphael Gottardo (1558), Hung V. Trinh (5146997), Sai Tian (1795663), Robert J. O’Connell (519953), Christine E. Linton (5147003), Yingxia Wen (2455015), Sayali Onkar (5147009), Barton F. Haynes (140266), Frank Situ (5147006), Giuseppe Palladino (211627), Nathalie Norais (159651), Susan W. Barnett (120170), Mangala Rao (147350), Celia LaBranche (170898), Gillis Otten (5147018), Padma Malyala (5147012), David C. Montefiori (108747), Georgia D. Tomaras (164058), Jeffrey B. Ulmer (120136), Chiara Tani (3572036), Yukti Aggarwal (816042), Yide Sun (334156), Selen Karaca-Griffin (5147015)   +38 more
core   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Investigating the role of N-linked glycosylation system in bacteria [PDF]

Glycosylation is the most abundant protein post-translational modification found in nature. The attachment of glycans to proteins has been shown to play a central role in modulating protein folding, stability, and signalling.
Abouelhadid, S
core   +1 more source