Results 101 to 110 of about 15,085,302 (278)

N-Linked Glycosylation in Archaea: a Structural, Functional, and Genetic Analysis [PDF]

Microbiology and Molecular Biology Reviews, 2014
SUMMARYN-glycosylation of proteins is one of the most prevalent posttranslational modifications in nature. Accordingly, a pathway with shared commonalities is found in all three domains of life. While excellent model systems have been developed for studying N-glycosylation in bothEukaryaandBacteria, an understanding of this process inArchaeawas ...
Jarrell, Ken F., Ding, Yan, Meyer, Benjamin H., Albers, Sonja Verena, Kaminski, Lina, Eichler, Jerry   +5 more
openaire   +5 more sources

A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction [PDF]

, 2008
Feline immunodeficiency virus (FIV) targets helper T cells by attachment of the envelope glycoprotein (Env) to CD134, a subsequent interaction with CXCR4 then facilitating the process of viral entry.
Margaret J Hosie, Ayman Samman, Willett Brian J, Samman, Ayman, Logan Nicola, Brian J Willett, Samman Ayman, McMonagle, Elizabeth L., Hosie Margaret J, Logan, Nicola, McMonagle Elizabeth L, Nicola Logan, Hosie, Margaret J., Willett, Brian J., Elizabeth L McMonagle   +14 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Biosynthesis of Conjugate Vaccines Using an O-Linked Glycosylation System

mBio, 2016
Conjugate vaccines are known to be one of the most effective and safest types of vaccines against bacterial pathogens. Previously, vaccine biosynthesis has been performed by using N-linked glycosylation systems.
Chao Pan, Peng Sun, Bo Liu, Haoyu Liang, Zhehui Peng, Yan Dong, Dongshu Wang, Xiankai Liu, Bin Wang, Ming Zeng, Jun Wu, Li Zhu, Hengliang Wang   +12 more
doaj   +1 more source

The annotation of the asparagine N-linked glycosylation pathway in the Reactome database [PDF]

Glycobiology, 2011
Asparagine N-linked glycosylation is one of the most important forms of protein post-translational modification in eukaryotes and is one of the first metabolic pathways described at a biochemical level. Here, we report a new annotation of this pathway for the Human species, published after passing a peer-review process in Reactome.
Dall'Olio, Giovanni Marco, 1983-, Jassal, Bijay, Montanucci, Ludovica, 1978-, Gagneux, Pascal, Bertranpetit, Jaume, 1952-, Laayouni, Hafid, 1968-   +5 more
openaire   +4 more sources

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

N-glycosylation in the Pre-Membrane Protein Is Essential for the Zika Virus Life Cycle

Viruses, 2020
Asparagine (N)-linked protein glycosylation plays an important role in protein synthesis and modification. Two Zika virus (ZIKV) structural proteins, the pre-membrane (prM) and envelope (E) protein are N-glycosylated.
Yong-Dae Gwon, Eva Zusinaite, Andres Merits, Anna K. Överby, Magnus Evander   +4 more
doaj   +1 more source

Centralized modularity of N-linked glycosylation pathways in mammalian cells. [PDF]

PLoS ONE, 2009
Glycosylation is a highly complex process to produce a diverse repertoire of cellular glycans that are attached to proteins and lipids. Glycans are involved in fundamental biological processes, including protein folding and clearance, cell proliferation ...
Pan-Jun Kim, Dong-Yup Lee, Hawoong Jeong
doaj   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Fc-Linked IgG N-Glycosylation in FcγR Knock-Out Mice

Frontiers in Cell and Developmental Biology, 2020
Immunoglobulin G (IgG) is the most abundant immunoglobulin isotype in the blood and is involved in the pathogenesis and progression of various diseases.
Olga O. Zaytseva, Michaela Seeling, Jasminka Krištić, Gordan Lauc, Gordan Lauc, Marija Pezer, Falk Nimmerjahn   +6 more
doaj   +1 more source