Results 11 to 20 of about 15,085,302 (278)

Impact of N-Linked Glycosylation on Therapeutic Proteins [PDF]

Molecules, 2022
Therapeutic proteins have unique advantages over small-molecule drugs in the treatment of various diseases, such as higher target specificity, stronger pharmacological efficacy and relatively low side effects.
Baoquan Chen, Wenqiang Liu, Yaohao Li, Bo Ma, Shiying Shang, Zhongping Tan   +5 more
doaj   +4 more sources

Deficiency of N-linked glycosylation impairs immune function of B7-H6 [PDF]

Frontiers in Immunology, 2023
B7-H6 is a novel immune checkpoint molecule that triggers NK cell cytotoxicity, but the role of N-glycosylation in B7-H6 is poorly understood. We here identified the existence of N-glycosylation of B7-H6 in different cell lines and exogenous expression ...
Hanqing Chen, Hanqing Chen, Yang Zhang, Yu Shen, Liang Jiang, Guangbo Zhang, Xueguang Zhang, Yang Xu, Yang Xu, Fengqing Fu   +9 more
doaj   +4 more sources

Role of N-Linked Glycosylation in PKR2 Trafficking and Signaling [PDF]

Frontiers in Neuroscience, 2021
Prokineticin receptors are GPCRs involved in several physiological processes including the regulation of energy homeostasis, nociception, and reproductive function.
Jissele A. Verdinez, Jissele A. Verdinez, Jissele A. Verdinez, Julien A. Sebag, Julien A. Sebag, Julien A. Sebag   +5 more
doaj   +5 more sources

N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer [PDF]

Cell Death and Disease, 2023
KIAA1324 is a transmembrane protein largely reported as a tumor suppressor and favorable prognosis marker in various cancers, including gastric cancer.
Rebecca Yun, Eunji Hong, Junil Kim, Bora Park, Staci Jakyong Kim, Bona Lee, Yong Sang Song, Seong-Jin Kim, Sujin Park, Jin Muk Kang   +9 more
doaj   +2 more sources

DeepNGlyPred: A Deep Neural Network-Based Approach for Human N-Linked Glycosylation Site Prediction

Molecules, 2021
Protein N-linked glycosylation is a post-translational modification that plays an important role in a myriad of biological processes. Computational prediction approaches serve as complementary methods for the characterization of glycosylation sites. Most
Subash C. Pakhrin, Kiyoko F. Aoki-Kinoshita, Doina Caragea, Dukka B. KC   +3 more
doaj   +3 more sources

Altered N-linked glycosylation in endometrial cancer

Analytical and Bioanalytical Chemistry, 2020
It is well established that cell surface glycans play a vital role in biological processes and their altered form can lead to carcinogenesis. Mass spectrometry-based techniques have become prominent for analysing N-linked glycans, for example using matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS).
Mittal, Parul, Briggs, Matthew, Klingler-Hoffmann, Manuela, Kaur, Gurjeet, Packer, Nicolle H, Oehler, Martin K, Hoffmann, Peter   +6 more
openaire   +4 more sources

Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas. [PDF]

Cancer Discov, 2023
Abstract Diffuse large B-cell lymphoma (DLBCL) can be subdivided into the activated B-cell (ABC) and germinal center B cell–like (GCB) subtypes. Self-antigen engagement of B-cell receptors (BCR) in ABC tumors induces their clustering, thereby initiating chronic active signaling and activation ...
Scheich S, Chen J, Liu J, Schnütgen F, Enssle JC, Enssle JC, Ceribelli M, Thomas CJ, Choi J, Morris V, Hsiao T, Nguyen H, Wang B, Bolomsky A, Phelan JD, Corcoran S, Urlaub H, Young RM, Häupl B, Wright GW, Huang DW, Ji Y, Yu X, Xu W, Yang Y, Zhao H, Muppidi J, Pan KT, Oellerich T, Staudt LM.   +29 more
europepmc   +5 more sources

N-Linked Glycosylation Regulates CD22 Organization and Function [PDF]

Frontiers in Immunology, 2019
The organization and clustering of cell surface proteins plays a critical role in controlling receptor signaling; however, the biophysical mechanisms regulating these parameters are not well understood.
Laabiah Wasim, Fathima Hifza Mohamed Buhari, Myuran Yoganathan, Taylor Sicard, Taylor Sicard, June Ereño-Orbea, Jean-Philippe Julien, Jean-Philippe Julien, Jean-Philippe Julien, Bebhinn Treanor, Bebhinn Treanor, Bebhinn Treanor   +11 more
doaj   +3 more sources

Defining albumin as a glycoprotein with multiple N-linked glycosylation sites [PDF]

Journal of Translational Medicine
Background Glycosylation is an enzyme-catalyzed post-translational modification that is distinct from glycation and is present on a majority of plasma proteins.
Kishore Garapati, Anu Jain, Benjamin J. Madden, Dong-Gi Mun, Jyoti Sharma, Rohit Budhraja, Akhilesh Pandey   +6 more
doaj   +2 more sources

N-linked glycosylation of GETV envelope proteins affect viral infection and pathogenicity [PDF]

Virulence
Getah virus (GETV) is an emerging mosquito-borne pathogen with a broad host range, posing a significant threat to livestock and public health. Although putative N-linked glycosylation sites on its envelope proteins have been reported, their precise ...
Hui Meng, Tianyi Wang, Chunxiao Mou, Yanmei Huang, Zhenhai Chen   +4 more
doaj   +2 more sources