Results 11 to 20 of about 15,265,728 (239)

Impact of N-Linked Glycosylation on Therapeutic Proteins [PDF]

Molecules, 2022
Therapeutic proteins have unique advantages over small-molecule drugs in the treatment of various diseases, such as higher target specificity, stronger pharmacological efficacy and relatively low side effects.
Baoquan Chen, Wenqiang Liu, Yaohao Li, Bo Ma, Shiying Shang, Zhongping Tan   +5 more
doaj   +2 more sources

N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer [PDF]

Cell Death and Disease, 2023
KIAA1324 is a transmembrane protein largely reported as a tumor suppressor and favorable prognosis marker in various cancers, including gastric cancer.
Rebecca Yun, Eunji Hong, Junil Kim, Bora Park, Staci Jakyong Kim, Bona Lee, Yong Sang Song, Seong-Jin Kim, Sujin Park, Jin Muk Kang   +9 more
doaj   +2 more sources

DeepNGlyPred: A Deep Neural Network-Based Approach for Human N-Linked Glycosylation Site Prediction

Molecules, 2021
Protein N-linked glycosylation is a post-translational modification that plays an important role in a myriad of biological processes. Computational prediction approaches serve as complementary methods for the characterization of glycosylation sites. Most
Subash C. Pakhrin, Kiyoko F. Aoki-Kinoshita, Doina Caragea, Dukka B. KC   +3 more
doaj   +3 more sources

Deficiency of N-linked glycosylation impairs immune function of B7-H6 [PDF]

Frontiers in Immunology, 2023
B7-H6 is a novel immune checkpoint molecule that triggers NK cell cytotoxicity, but the role of N-glycosylation in B7-H6 is poorly understood. We here identified the existence of N-glycosylation of B7-H6 in different cell lines and exogenous expression ...
Hanqing Chen, Hanqing Chen, Yang Zhang, Yu Shen, Liang Jiang, Guangbo Zhang, Xueguang Zhang, Yang Xu, Yang Xu, Fengqing Fu   +9 more
doaj   +2 more sources

N-linked glycosylation of GETV envelope proteins affect viral infection and pathogenicity [PDF]

Virulence
Getah virus (GETV) is an emerging mosquito-borne pathogen with a broad host range, posing a significant threat to livestock and public health. Although putative N-linked glycosylation sites on its envelope proteins have been reported, their precise ...
Hui Meng, Tianyi Wang, Chunxiao Mou, Yanmei Huang, Zhenhai Chen   +4 more
doaj   +2 more sources

Defining albumin as a glycoprotein with multiple N-linked glycosylation sites [PDF]

Journal of Translational Medicine
Background Glycosylation is an enzyme-catalyzed post-translational modification that is distinct from glycation and is present on a majority of plasma proteins.
Kishore Garapati, Anu Jain, Benjamin J. Madden, Dong-Gi Mun, Jyoti Sharma, Rohit Budhraja, Akhilesh Pandey   +6 more
doaj   +2 more sources

An analytical study on the identification of N-linked glycosylation sites using machine learning model [PDF]

PeerJ Computer Science, 2022
N-linked is the most common type of glycosylation which plays a significant role in identifying various diseases such as type I diabetes and cancer and helps in drug development.
Muhammad Aizaz Akmal, Muhammad Awais Hassan, Shoaib Muhammad, Khaldoon S. Khurshid, Abdullah Mohamed   +4 more
doaj   +3 more sources

The N-linked glycosylation modifications in the hepatitis B surface protein impact cellular autophagy, HBV replication, and HBV secretion. [PDF]

PLoS ONE
N-linked glycosylation is a pivotal post-translational modification that significantly influences various aspects of protein biology. Autophagy, a critical cellular process, is instrumental in cell survival and maintenance.
Patcharin Tepjanta, Kazuhito Fujiyama, Ryo Misaki, Ingorn Kimkong   +3 more
doaj   +2 more sources

Role of N-Linked Glycosylation in PKR2 Trafficking and Signaling [PDF]

Frontiers in Neuroscience, 2021
Prokineticin receptors are GPCRs involved in several physiological processes including the regulation of energy homeostasis, nociception, and reproductive function.
Jissele A. Verdinez, Jissele A. Verdinez, Jissele A. Verdinez, Julien A. Sebag, Julien A. Sebag, Julien A. Sebag   +5 more
doaj   +2 more sources

N-linked glycosylation of PD-L1/PD-1: an emerging target for cancer diagnosis and treatment [PDF]

Journal of Translational Medicine
During tumorigenesis and progression, the immune checkpoint programmed death-1 (PD-1) and its ligand programmed death ligand-1 (PD-L1) play critical roles in suppressing T cell-mediated anticancer immune responses, leading to T-cell exhaustion and ...
Zhiyun Duan, Runhan Shi, Bo Gao, Jiabin Cai   +3 more
doaj   +2 more sources