Results 41 to 50 of about 15,085,302 (278)

N-linked glycosylation and homeostasis of the endoplasmic reticulum [PDF]

Current Opinion in Cell Biology, 2016
As a major site of protein biosynthesis, homeostasis of the endoplasmic reticulum is critical for cell viability. Asparagine linked glycosylation of newly synthesized proteins by the oligosaccharyltransferase plays a central role in ER homeostasis due to the use of protein-linked oligosaccharides as recognition and timing markers for glycoprotein ...
Natalia Cherepanova, Shiteshu Shrimal, Reid Gilmore   +2 more
openaire   +2 more sources

N-Linked Protein Glycosylation in the Endoplasmic Reticulum [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
The attachment of glycans to asparagine residues of proteins is an abundant and highly conserved essential modification in eukaryotes. The N-glycosylation process includes two principal phases: the assembly of a lipid-linked oligosaccharide (LLO) and the transfer of the oligosaccharide to selected asparagine residues of polypeptide chains. Biosynthesis
Breitling J, Aebi M
openaire   +3 more sources

The N-linking glycosylation system from Actinobacillus pleuropneumoniae is required for adhesion and has potential use in glycoengineering [PDF]

Open Biology, 2017
Actinobacillus pleuropneumoniae is a mucosal respiratory pathogen causing contagious porcine pleuropneumonia. Pathogenesis studies have demonstrated a major role for the capsule, exotoxins and outer membrane proteins.
Jon Cuccui, Vanessa S. Terra, Janine T. Bossé, Andreas Naegeli, Sherif Abouelhadid, Yanwen Li, Chia-Wei Lin, Prerna Vohra, Alexander W. Tucker, Andrew N. Rycroft, Duncan J. Maskell, Markus Aebi, Paul R. Langford, Brendan W. Wren,   +14 more
doaj   +1 more source

Effects of N-linked glycosylation on the creatine transporter [PDF]

Biochemical Journal, 2005
The CRT (creatine transporter) is a member of the Na+- and Cl−-dependent neurotransmitter transporter family and is responsible for the import of creatine into cells, and thus is important for cellular energy metabolism. We established for CRT an expression system in HEK-293 cells that allowed biochemical, immunological and functional analysis of CRT ...
Straumann, Nadine, Wind, Alexandra, Leuenberger, Tina, Wallimann, Theo   +3 more
openaire   +4 more sources

Autosomal Recessive Dilated Cardiomyopathy due to DOLK Mutations Results from Abnormal Dystroglycan O-Mannosylation [PDF]

, 2011
Genetic causes for autosomal recessive forms of dilated cardiomyopathy (DCM) are only rarely identified, although they are thought to contribute considerably to sudden cardiac death and heart failure, especially in young children.
van Reeuwijk, Jeroen, Schuurs-Hoeijmakers, Janneke H. M., Lehle Ludwig, Schuurs-Hoeijmakers, J.H., Lorber, A., Lorber, Avraham, Zucker, N., Janneke H M Schuurs-Hoeijmakers, Zucker Nili, Grünewald Stephanie, de Brouwer Arjan P. M., Wevers, R.A., Steenbergen, Gerry, Lefeber, D.J., Steenbergen, G.C., Lammens, M.M.Y., Ron A Wevers, Adam Jozwiak, Schuurs-Hoeijmakers, Janneke H M, Wevers, Ron A., Huijben, K., Grunewald, S., Lefeber, Dirk J, Gruenewald, Stephanie, Wevers, Ron A, Willem M R van den Akker, van den Akker, Willem M. R., de Brouwer, Arjan P. M., van Bokhoven, H., Steenbergen Gerry, Hanna Mandel, Riemersma Moniek, Riemersma, Moniek, Gerry Steenbergen, Riemersma, M., Stephanie Grünewald, Lammens, Martin, Dirk J Lefeber, Eva Morava, Absmanner, B., Morava Eva, Verrijp, K., Knopf, Carlos, Verrijp, Kiek, Knopf, C., van Bokhoven, Hans, Brouwer, A.P.M. de, van den Akker Willem M. R., Nili Zucker, Jeroen van Reeuwijk, Mandel, H., Lammens Martin, Martin Lammens, Jozwiak, Adam, Carlos Knopf, de Brouwer, A.P., Absmanner, Birgit, Mandel Hanna, Hans van Bokhoven, Reeuwijk, J. van, Jozwiak, A., Ludwig Lehle, Schuurs-Hoeijmakers Janneke H. M., Lehle, Ludwig, Lorber Avraham, Huijben Karin, van Reeuwijk, J., Zucker, Nili, Hijben, K., van den Akker, Willem M R, Birgit Absmanner, Absmanner Birgit, Avraham Lorber, Steenbergen, G., Huijben, Karin, Wevers Ron A., Mandel, Hanna, Knopf Carlos, Kapusta, Livia, Lefeber, Dirk J., Livia Kapusta, Verrijp Kiek, van den Akker, W.M., Grunewald, Stephanie, van Bokhoven Hans, Morava, E., Akker, W.M.R. van den, Moniek Riemersma, Bokhoven, H. van, Lefeber Dirk J., Jozwiak Adam, Lehle, L., Kapusta, L., Lammens, M., van Reeuwijk Jeroen, Karin Huijben, Schuurs-Hoeijmakers, J.H.M., Morava, Eva, Kapusta Livia, Arjan P M de Brouwer, Kiek Verrijp   +100 more
core   +5 more sources

Oligosaccharyltransferase: the central enzyme of N‐linked protein glycosylation [PDF]

Journal of Inherited Metabolic Disease, 2011
AbtractN‐linked glycosylation is one of the most abundant modifications of proteins in eukaryotic organisms. In the central reaction of the pathway, oligosaccharyltransferase (OST), a multimeric complex located at the membrane of the endoplasmic reticulum, transfers a preassembled oligosaccharide to selected asparagine residues within the consensus ...
Mohorko Elisabeth, Glockshuber Rudi, Aebi Markus   +2 more
openaire   +4 more sources

Structural Insight into the Mechanism of N-Linked Glycosylation by Oligosaccharyltransferase

Biomolecules, 2020
Asparagine-linked glycosylation, also known as N-linked glycosylation is an essential and highly conserved post-translational protein modification that occurs in all three domains of life. This modification is essential for specific molecular recognition,
Smita Mohanty, Bharat P Chaudhary, David Zoetewey   +2 more
doaj   +1 more source

Genomic and Biochemical Analysis of N Glycosylation in the Mushroom-Forming Basidiomycete Schizophyllum commune [PDF]

, 2009
N-linked glycans of Schizophyllum commune consist of Man(5-9)GlcNAc(2) structures. Lack of further glycan maturation is explained by the absence of genes encoding such functions in this and other homobasidiomycetes.
de Jong, J.F., Jong, J.F., de, Wosten, H.A.B., Ohm, R.A., Bosch, G.B.M., van den, Molecular Microbiology, Lugones, L.G., Sub Molecular Microbiology, van den Bosch, G.B.M., Sub Membrane Biochemistry & Biophysics, Rouwendal, G.J.A., Bosch, D., Dep Scheikunde, Berends, E., Membrane Enzymology   +14 more
core   +2 more sources

HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments

Virology Journal, 2008
Background N-linked glycosylation is a major mechanism for minimizing virus neutralizing antibody response and is present on the Human Immunodeficiency Virus (HIV) envelope glycoprotein.
Ho Yung, Abecasis Ana B, Theys Kristof, Deforche Koen, Dwyer Dominic E, Charleston Michael, Vandamme Anne, Saksena Nitin K   +7 more
doaj   +1 more source

Sugar activation and glycosylation in Plasmodium [PDF]

, 2015
TKS thanks previous funding from the Wellcome Trust (093228), SUSLA and BBSRC, and current funding from MRC (MR/M020118/1) and European Community’s Seventh Framework Programme under grant agreement No. 602773 (Project KINDRED). MC, JAR and LI are members
Smith, Terry K., Smith, Terry K, Izquierdo Lázaro, Luis, João A. Rodrigues, Rodrigues, João A., Cova, Marta, Marta Cova, Terry K. Smith, Izquierdo, Luis, Luis Izquierdo   +9 more
core   +1 more source