Results 21 to 30 of about 15,085,302 (278)

PUStackNGly: Positive-Unlabeled and Stacking Learning for N-Linked Glycosylation Site Prediction

IEEE Access, 2022
N-linked glycosylation is one of the most common protein post-translation modifications (PTMs) in humans where the Asparagine (N) amino acid of the protein is attached to the glycan. It is involved in most biological processes and associated with various
Alhasan Alkuhlani, Walaa Gad, Mohamed Roushdy, Abdel-Badeeh M. Salem   +3 more
doaj   +3 more sources

The N-linked glycosylation modifications in the hepatitis B surface protein impact cellular autophagy, HBV replication, and HBV secretion. [PDF]

PLoS ONE
N-linked glycosylation is a pivotal post-translational modification that significantly influences various aspects of protein biology. Autophagy, a critical cellular process, is instrumental in cell survival and maintenance.
Patcharin Tepjanta, Kazuhito Fujiyama, Ryo Misaki, Ingorn Kimkong   +3 more
doaj   +2 more sources

An analytical study on the identification of N-linked glycosylation sites using machine learning model [PDF]

PeerJ Computer Science, 2022
N-linked is the most common type of glycosylation which plays a significant role in identifying various diseases such as type I diabetes and cancer and helps in drug development.
Muhammad Aizaz Akmal, Muhammad Awais Hassan, Shoaib Muhammad, Khaldoon S. Khurshid, Abdullah Mohamed   +4 more
doaj   +3 more sources

N-linked protein glycosylation in the ER [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013
N-linked protein glycosylation in the endoplasmic reticulum (ER) is a conserved two phase process in eukaryotic cells. It involves the assembly of an oligosaccharide on a lipid carrier, dolichylpyrophosphate and the transfer of the oligosaccharide to selected asparagine residues of polypeptides that have entered the lumen of the ER. The assembly of the
Aebi, Markus
openaire   +4 more sources

N-linked glycosylation of PD-L1/PD-1: an emerging target for cancer diagnosis and treatment [PDF]

Journal of Translational Medicine
During tumorigenesis and progression, the immune checkpoint programmed death-1 (PD-1) and its ligand programmed death ligand-1 (PD-L1) play critical roles in suppressing T cell-mediated anticancer immune responses, leading to T-cell exhaustion and ...
Zhiyun Duan, Runhan Shi, Bo Gao, Jiabin Cai   +3 more
doaj   +2 more sources

Effect of N-linked glycosylation on hepatic lipase activity

Journal of Lipid Research, 1991
Hepatic lipase (HL) is a secretory protein synthesized in hepatocytes and bound to liver endothelium. Previous studies have suggested that HL N-linked glycans are required for catalytic activity.
G Stahnke, RC Davis, MH Doolittle, H Wong, MC Schotz, H Will   +5 more
doaj   +3 more sources

N-Linked Glycosylation Prevents Deamidation of Glycopeptide and Glycoprotein [PDF]

ACS Chemical Biology, 2020
Deamidation has been recognized as a common spontaneous pathway of protein degradation and a prevalent concern in the pharmaceutical industry; deamidation caused the reduction of protein/peptide drug efficacy and shelf life in several cases. More importantly, deamidation of physiological proteins is related to several human diseases and considered a ...
Hailiang Joshua Zhu, Ding Liu, Vy P. Tran, Zhigang Wu, Kuan Jiang, He Zhu, Jiabin Zhang, Christopher Gibbons, Bingzhong Xue, Hang Shi, Peng George Wang   +10 more
openaire   +4 more sources

Characterization of N-Linked Protein Glycosylation in Helicobacter pullorum [PDF]

Journal of Bacteriology, 2010
ABSTRACT The first bacterial N-linked glycosylation system was discovered in Campylobacter jejuni , and the key enzyme involved in the coupling of glycan to asparagine residues within the acceptor sequon of the glycoprotein is the oligosaccharyltransferase PglB.
Jervis, Adrian J., Langdon, Rebecca, Hitchen, Paul, Lawson, Andrew J., Wood, Alison, Fothergill, Joanne L., Morris, Howard R., Dell, Anne, Wren, Brendan, Linton, Dennis; id_orcid 0000-0002-4717-5428   +9 more
openaire   +3 more sources

Ethanol-induced impairment in the biosynthesis of N-linked glycosylation [PDF]

Journal of cellular biochemistry, 2014
Deficiency in N-linked protein glycosylation is a long-known characteristic of alcoholic liver disease and congenital disorders of glycosylation. Previous investigations of ethanol-induced glycosylation deficiency demonstrated perturbations in the early steps of substrate synthesis and in the final steps of capping N-linked glycans in the Golgi.
Welti, Michael, Hülsmeier, Andreas J
openaire   +5 more sources

Emerging roles of N-linked glycosylation in brain physiology and disorders [PDF]

Trends in Endocrinology and Metabolism, 2021
Matthew Gentry, Ramon Sun, Lyndsay Young   +2 more
exaly   +2 more sources