Results 61 to 70 of about 15,085,302 (278)

N-Linked Glycosylation in the Hemagglutinin of Influenza A Viruses

Yonsei Medical Journal, 2012
Since the 1918 influenza A virus (IAV) pandemic, H1N1 viruses have circulated in human populations. The hemagglutinin (HA) of IAV determines viral antigenicity and often undergoes N-linked glycosylation (NLG) at several sites. Interestingly, structural analysis of the 1918 and 2009 H1N1 pandemic viruses revealed antigenic similarities attributable to ...
Kim, Jin Il, Park, Man-Seong
openaire   +2 more sources

Dysregulation of the expression of asparagine-linked glycosylation 13 short isoform 2 affects nephrin function by altering its N-linked glycosylation [PDF]

, 2017
BACKGROUND\ud \ud N-linked glycosylation, which is a post-translational modification process, plays an important role in protein folding, intracellular trafficking and membrane targeting, as well as in regulating the protein function.
Mafalda Giovanna Reccia, Lyn R. Griffiths, Filomena Napolitano, Napolitano, Filomena, Saleem, Moin A, Alessia Lombardi, De Stefano, Giovanni, Di Lorenzo, Ilaria, Griffiths, Lyn R, Ilaria Di Lorenzo, Francesco Scalabrì, Lombardi, Alessia, Saleem, Moin A., Gianfrancesco, Fernando, Teresa Esposito, Moin A. Saleem, Reccia, Mafalda Giovanna, Griffiths, Lyn R., Giovanni De Stefano, Esposito, Teresa, Fernando Gianfrancesco, Scalabrì, Francesco   +21 more
core   +1 more source

Biological Functions of Glycosylation and Their Application in Glycoengineered Therapeutics

ChemEngineering
Glycosylation is the most common post-translational modification in the human proteome, with over half of all human proteins bearing covalently attached glycans.
Corbyn Kubalek, Spencer Gardiner, William Heaps, Kristina M. McCammon, Sam Talcott, Matthew Argyle, Bradley C. Bundy, Dennis Della Corte   +7 more
doaj   +1 more source

Modeling Congenital Disorders of N-Linked Glycoprotein Glycosylation in Drosophila melanogaster

Frontiers in Genetics, 2018
Protein glycosylation, the enzymatic addition of N-linked or O-linked glycans to proteins, serves crucial functions in animal cells and requires the action of glycosyltransferases, glycosidases and nucleotide-sugar transporters, localized in the ...
Anna Frappaolo, Stefano Sechi, Tadahiro Kumagai, Angela Karimpour-Ghahnavieh, Michael Tiemeyer, Michael Tiemeyer, Maria Grazia Giansanti   +6 more
doaj   +1 more source

Characterisation of N-linked protein glycosylation in the bacterial pathogen Campylobacter hepaticus

Scientific Reports, 2023
Campylobacter hepaticus is an important pathogen which causes Spotty Liver Disease (SLD) in layer chickens. SLD results in an increase in mortality and a significant decrease in egg production and therefore is an important economic concern of the global ...
Jamieson B. McDonald, Nichollas E. Scott, Greg J. Underwood, Daniel M. Andrews, Thi Thu Hao Van, Robert J. Moore   +5 more
doaj   +1 more source

Evidence for N-linked glycosylation in Toxoplasma gondii [PDF]

Biochemical Journal, 1993
In this paper we report experiments demonstrating the presence of N-linked oligosaccharide structures in Toxoplasma gondii tachyzoites, providing the first direct biochemical evidence that this sporozoan parasite is capable of synthesizing N-linked glycans. The tachyzoite surface glycoprotein gp23 was metabolically labelled with [3H]glucosamine and [3H]
M, Odenthal-Schnittler, S, Tomavo, D, Becker, J F, Dubremetz, R T, Schwarz   +4 more
openaire   +2 more sources

Protein glycosylation in the gram-negative gamma proteobacterium photorhabdus luminescens [PDF]

, 2011
The objective of this research was to investigate the possibility that Photorhabdus luminescens produces glycoproteins and thus contains a protein glycosylation system. P. luminescens is a pathogen of insects and a symbiont of soil nematodes.
Fox, Mary
core   +2 more sources

Effects of exercise on the hexosamine biosynthetic pathway and glycosylation

Journal of Physical Fitness and Sports Medicine, 2012
Minor amounts of glucose incorporated into the cells is metabolized via the hexosamine biosynthetic pathway, resulting in the production of uridine-5’-diphosphate-N-acetylglucosamine (UDP-GlcNAc), which is utilized as a donor substrate for the N- and O ...
Ken Shirato, Takako Kizaki, Hideki Ohno, Kazuhiko Imaizumi   +3 more
doaj   +1 more source

Differential Effects of D-Galactose Supplementation on Golgi Glycosylation Defects in TMEM165 Deficiency

Frontiers in Cell and Developmental Biology, 2022
Glycosylation is a ubiquitous and universal cellular process in all domains of life. In eukaryotes, many glycosylation pathways occur simultaneously onto proteins and lipids for generating a complex diversity of glycan structures.
Zoé Durin, Marine Houdou, Willy Morelle, Lydia Barré, Aurore Layotte, Dominique Legrand, Mohamed Ouzzine, François Foulquier   +7 more
doaj   +1 more source

N-glycosylation-dependent control of functional expression of background potassium channels K2P3.1 and K2P9.1

, 2013
Two-pore domain potassium (K2P) channels play fundamental roles in cellular processes by enabling a constitutive leak of potassium from cells in which they are expressed, thus influencing cellular membrane potential and activity.
Roncoroni, Laura, Lowry, Eleanor, Johnson, Daniel, O'Kelly, Ita, Williams, Sarah, Mant, Alexandra   +5 more
core   +1 more source