Results 41 to 50 of about 7,619 (159)

Sex differences in the effects of N‐ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression

British Journal of Pharmacology, Volume 181, Issue 22, Page 4491-4513, November 2024.
Abstract Background and Purpose New psychoactive substances such as N‐ethylpentylone (NEP) are continuously emerging in the illicit drug market, and knowledge of their effects and risks, which may vary between sexes, is scarce. Our present study compares some key effects of NEP in male and female mice.
María Espinosa‐Velasco, Adriana Castro‐Zavala, Marina D. Reguilón, Inés Gallego‐Landin, Marina Bellot, Olga Rublinetska, Olga Valverde, Marta Rodríguez‐Arias, Núria Nadal‐Gratacós, Xavier Berzosa, Cristian Gómez‐Canela, Marcel·lí Carbó, Jorge Camarasa, Elena Escubedo, Raúl López‐Arnau, David Pubill   +15 more
wiley   +1 more source

Terapias emergentes en el trastorno de estrés postraumático [PDF]

, 2021
El trastorno de estrés postraumático (TEPT) es un trastorno psiquiátrico debilitante que se desarrolla después de la exposición a un trauma grave. La sintomatología incluye recuerdos intrusivos y sueños angustiosos relacionados con el trauma, evitación ...
Pérez Checa, Mario
core  

Novel harm reduction measures at music festivals in Australia: Pilot implementation of the Emerging Drugs Network of Australia–Victoria toxicosurveillance methodology

Drug and Alcohol Review, Volume 43, Issue 7, Page 2045-2054, November 2024.
Abstract Introduction Harm reduction strategies at music festivals seek to create a safer environment for patrons. The Emerging Drugs Network of Australia–Victoria (EDNAV) project is a state‐wide toxicosurveillance network that derives drug intelligence from a sample of patients presenting to hospital with illicit drug‐related toxicity.
Rebekka Syrjanen, Martin Dutch, Shaun L. Greene, Tom Lyons, Ginny McKinnon, Dimitri Gerostamoulos, Jennifer L. Schumann, on behalf of the EDNAV Project Research Group   +7 more
wiley   +1 more source

Quantitative analysis of tetrahydrocannabinol isomers and other toxicologically relevant drugs in blood

Drug Testing and Analysis, Volume 16, Issue 10, Page 1102-1112, October 2024.
Isomers of tetrahydrocannabinol (THC) may complicate valid and defensible confirmatory analysis in forensic toxicology. This article presents a multi‐analyte liquid chromatography‐tandem mass spectrometry method involving the separation of THC isomers in addition to other commonly encountered drugs and metabolites.
Dylan Mantinieks, Matthew Di Rago, Olaf H. Drummer, Linda Glowacki, Jennifer Schumann, Dimitri Gerostamoulos   +5 more
wiley   +1 more source

Trends in toxicological findings in unintentional opioid or stimulant toxicity deaths in Québec, Canada, 2012–2021: Has Québec entered a new era of drug‐related deaths?

Drug and Alcohol Review, Volume 43, Issue 6, Page 1613-1624, September 2024.
Abstract Introduction We aimed to describe rates and toxicological findings of unintentional opioid and stimulant toxicity deaths, 2012–2021. Methods The dataset included accidental deaths determined by the Coroner to be due to opioids or stimulants.
Uyen Do, Paul‐André Perron, Julie Bruneau, Sarah Larney   +3 more
wiley   +1 more source

Interventions for Complex Traumatic Events (INCiTE): Systematic review and research prioritisation exercise [PDF]

, 2020
Background: People with a history of complex traumatic events typically experience trauma and stressor disorders and additional mental comorbidities. It is not known if existing evidence-based treatments are effective and acceptable for this group of ...
Barbui, Corrado, Churchill, Rachel Christine, Coventry, Peter, Dale, Holly, Gilbody, Simon, Jones-Diette, Julie Susan, Lovell, Karina, McMillan, Dean, Meader, Nicholas, Melton, Hollie Anne, Shah, Iram, Temple, Melanie, Wright, Kath   +12 more
core   +1 more source

Bioisosteric analogs of MDMA: Improving the pharmacological profile?

Journal of Neurochemistry, Volume 168, Issue 9, Page 2022-2042, September 2024.
This study explores three new bioisosteric replacements of the methylenedioxy group of MDMA, resulting in ODMA, TDMA, and SeDMA. Compared to MDMA, these bioisosteres have shown an alternative hepatic metabolism, with different resulting metabolites and an improved metabolic stability for TDMA.
Ana Sofia Alberto‐Silva, Selina Hemmer, Hailey A. Bock, Leticia Alves da Silva, Kenneth R. Scott, Nina Kastner, Manan Bhatt, Marco Niello, Kathrin Jäntsch, Oliver Kudlacek, Elena Bossi, Thomas Stockner, Markus R. Meyer, John D. McCorvy, Simon D. Brandt, Pierce Kavanagh, Harald H. Sitte   +16 more
wiley   +1 more source

Comparison of the Effects of Ecstasy and Methamphetamine on the RB1 Mouse Embryonic Stem Cells Differentiation into Neural Cells

مجله دانشکده پزشکی اصفهان, 2013
Background: N-Methyl-3,4-Methylenedioxymethamphetamine (MDMA) and methamphetamine (MA) from the amphetamine family, which are respectively known as ecstasy and ice, have well-established neurotoxic effects on the serotonergic and dopaminergic systems ...
Leila Dehghani, Rokhsareh Meamar
doaj  

Psychedelic therapy in depression and substance use disorders

European Journal of Neuroscience, Volume 60, Issue 2, Page 4063-4077, July 2024.
Psychedelics changes in perception through serotonin receptor agonism. Effects on the 5HT2A receptor; neuroplasticity and transcriptomic regulation, as well as specific changes in neural correlates of brain networks. Psychedelic‐assisted therapy in disorders such as depression, anxiety and substance use disorders constitutes a strong research area ...
Nur Damla Korkmaz, Ugur Cikrikcili, Merve Akan, Emrah Yucesan   +3 more
wiley   +1 more source

Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease

Advanced Therapeutics, Volume 7, Issue 5, May 2024.
Black phosphorus microbubbles (BP@MBs) combined with focused ultrasound to open the blood‐brain barrier for treatment of Parkinson's disease (PD) is constructed. BP@MBs have antioxidant effects, reduce neuronal apoptosis and improve motor symptoms of PD in vitro and in vivo.
Shuyuan Guo, Zhuxia Zhang, Bingxuan Xu, Mengxin Wang, Taojian Fan, Xinliang Zhong, Azhen Hu, Die Hu, Lan Luo, Shuping Lin, Linlin Wang, Rongquan Yao, Jiabao Huang, Huiying Hu, Xintao Shuai, Jie Shi, Yun Chen, Tingting Zheng   +17 more
wiley   +1 more source