Results 121 to 130 of about 1,636 (167)
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Threshold for carcinogenicity of N-nitrosodiethylamine for esophageal tumors in rats
Food and Chemical Toxicology, 2003In a study on 4080 rats by Peto et al. [Cancer Res. 51 (1991) 6415], esophageal neoplasms induced by N-nitrosodiethylamine (NDEA) were the tumors most clearly demonstrated to have a dose response from administration of the compound to male rats. However, they were unable to predict the shape of the dose-response curve at low doses.
W J Waddell
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Foetal Distribution and Metabolism of N‐Nitrosodiethylamine in Mice
Acta Pharmacologica Et Toxicologica, 1981Abstract:In pregnant NMRI mice, low‐temperature autoradiography was used to study the distribution of N‐14C‐nitrosodiethylamine in foetal tissues, and autoradiography with heated tape‐sections was used to trace nonvolatile metabolites. Autoradiography with14C‐acetate was used to distinguish the part of the radioactivity which upon the degradation of N ...
Eva Brittebo, Hans Tjalve
exaly +3 more sources
Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats
Chemico-Biological Interactions, 2006Antioxidants are one of the key players in tumorigenesis, several natural and synthetic antioxidants were shown to have anticancer effects. In the present investigation the efficacy of silymarin on the antioxidant status of N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in Wistar albino male rats were assessed.
Hanumantha Rao Balaji Raghavendran +2 more
exaly +3 more sources
N-Nitrosodiethylamine mutagenicity at low concentrations
Toxicology Letters, 2003N-Nitrosodiethylamine (NDEA) requires metabolic activation by cytochrome P450 enzymes, leading to electrophile species that react in DNA. Although, carcinogenicity is not an end point in genotoxicity assays, NDEA has been considered a weak carcinogen. In this study, we carried out an analysis of the mutagenicity at low concentrations of NDEA. Using SOS
Claudia Alessandra Fortes, Aiub +2 more
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Concordance of thresholds for carcinogenicity of N-nitrosodiethylamine
Archives of Toxicology, 2005Three publications on the carcinogenicity of N-nitrosodiethylamine (NDEA) in the livers of F-344 or Wistar rats were examined for concordance of the data. Two reports recorded the appearance of tumors after treatment with NDEA, although one used a different dosing schedule that included phenobarbital promotion.
William J, Waddell +2 more
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Sites of metabolism of N-nitrosodiethylamine in mice
Chemico-Biological Interactions, 1981Low-temperature whole-body autoradiography and autoradiography with heated sections in C57Bl mice injected with N-[14C]nitrosodiethylamine showed a homogenously distributed volatile radioactivity in most tissues--indicating an ability of the non-metabolized substance to freely pass the biological membranes and distribute evenly in the intra- and ...
E B, Brittebo, B, Löfberg, H, Tjälve
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Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine
Molecular and Cellular Biochemistry, 2008Chemopreventive effect of S-allylcysteine (constituent of garlic) on N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis was evaluated in Wistar rats. Significantly decreased lipid peroxidation products (thiobarbituric acid reactive substances-TBARS and lipid hydroperoxides) with increased level of reduced glutathione, increased activities of ...
Sivapatham, Sundaresan +1 more
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Modulation of flavocoenzyme levels in rat tissues by N-nitrosodiethylamine
Cancer Letters, 1989The hepatocarcinogen N-nitrosodiethylamine (NDEA) was administered continuously in drinking water (200 mg/l) to male Wistar rats, and at intervals tissues were examined for flavocoenzyme levels. Flavin adenine dinucleotide (FAD) and non-FAD riboflavin were determined fluorimetrically.
V S, Aboobaker, R K, Bhattacharya
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Carcinogenesis of N‐nitrosodiethylamine (DENA) in chickens and domestic cats
International Journal of Cancer, 1978AbstractThe environmental carcinogen N‐nitrosodiethyl‐amine (diethylnitrosamine, DENA) has been found to be carcinogenic in 18 animal species. In this study we demonstrate that, after intramuscular injection in chickens, it induces hepatocellular carcinomas of the liver and adenocarcinomas of the kidney.
D, Schmähl, M, Habs, S, Ivankovic
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Chemico-Biological Interactions, 2006
N-Nitroso compounds, such as N-nitrosodiethylamine (NDEA), are a versatile group of chemical carcinogens, being suspected to be involved in gastrointestinal tumors in humans. The intestinal microflora can modify a wide range of environmental chemicals either directly or in the course of enterohepatic circulation.
Claudia Alessandra Fortes, Aiub +3 more
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N-Nitroso compounds, such as N-nitrosodiethylamine (NDEA), are a versatile group of chemical carcinogens, being suspected to be involved in gastrointestinal tumors in humans. The intestinal microflora can modify a wide range of environmental chemicals either directly or in the course of enterohepatic circulation.
Claudia Alessandra Fortes, Aiub +3 more
openaire +2 more sources