Results 131 to 140 of about 1,636 (167)
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Photodegradation of N-nitrosodiethylamine in water with UV irradiation
Science Bulletin, 2008The direct photolysis of N-nitrosodiethylamine (NDEA) in water with ultraviolet (UV) irradiation was investigated. Results showed that NDEA could be completely degraded under the direct UV irradiation. The effects of the experimental conditions, including the initial concentration of NDEA, humic acid and solution pH, were studied.
BingBing Xu +3 more
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Drug Metabolism in Rats with Cancer Induced by N‐Nitrosodiethylamine and Phenobarbital
Pharmacology & Toxicology, 1992Abstract:The metabolism ofR‐ andS‐warfarinin vivoandin vitro, bufuralolin vitro, and antipyrine and debrisoquinein vivowere studied in rats with cancer induced byN‐nitrosodiethylamine and phenobarbital treatment. Microsomal cytochrome P‐450 content was greatly reduced in both healthy and cancerous parts of the livers of tumour‐bearing animals.
M L, Aitio +4 more
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Influence of disulfiram on the metabolism of N-nitrosodiethylamine.
IARC scientific publications, 1985The effect of disulfiram (DSF) on the biological activity of N-nitrosodiethylamine (NDEA) was studied in vivo. We determined its influence on NDEA level, on NDEA-induced DNA damage and on DNA alkylation in the liver and oesophagus. It was found that 500 mg/kg DSF given 2 h before a single dose of 28 mg/kg NDEA inhibited the metabolism and increased the
N, Frank, M, Wiessler, D, Hadjiolov
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Modulation of N-nitrosodiethylamine-induced hamster lung tumors by ozone
Toxicology, 1993Male Syrian Golden hamsters were treated with subcutaneous injections of N-nitrosodiethylamine (DEN), 20 mg/kg, twice a week for 24 weeks. Half the animals were kept in filtered air and the other half was exposed continuously to an atmosphere of 0.8 ppm of ozone.
H, Witschi, D W, Wilson, C G, Plopper
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[The dependence of the carcinogenic effect on the concentration of N-nitrosodiethylamine].
Voprosy onkologii, 1989In a 86-week-long experiment using 1087 mice (487 hybrids and 600 non-inbred animals), the concentration-effect relationship was studied for N-nitrosodiethylamine (NDEA) given in drinking water. NDEA concentrations of 0.08; 0.4; 2.0 and 10.0 mg/l produced tumors in male and female hybrids with the frequencies of 35.9/30.9, 49.9/43.6, 61.9/72.3 and 81.8/
V M, Voronin +4 more
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Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv.
Journal of experimental & clinical cancer research : CR, 2001Picroliv, an iridoid glycoside mixture prepared from the roots and rhizomes of Picrorhiza kurroa was found to be an effective inhibitor of hepatocarcinogenesis induced by N-Nitrosodiethylamine (NDEA) in rats. Animals administered with NDEA had large hepatic nodules and the liver weight was increased to 6.17 +/- 1.0 g/100 g.b.wt.
N V, Rajeshkumar, R, Kuttan
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Carcinogenic activity of N-nitrosodiethylamine in snakes
Naturwissenschaften, 1983D, Schmähl, H R, Scherf
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[Action of N-dinitrosopiperazine and N-nitrosodiethylamine on aquarium guppies].
Voprosy onkologii, 1982Tumors and precancerous lesions of the gastrointestinal tract were induced in aquarium fish guppy by dinitrosopiperazine and nitrosodiethylamine dissolved in aquarium water. Nitrosodiethylamine appeared to produce a stronger blastogenic effect than dinitrosopiperazine.
K, Simon +3 more
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[Effect of ethanol on the hepatocarcinogenic action of N-nitrosodiethylamine in rats].
Eksperimental'naia onkologiia, 1986It is shown that the administration of ethanol to male Wistar rats (3 g/kg by gastric tube 3 times a week for 2 months) before or at the beginning of the N-nitrosodiethylamine (NDEA) treatment (2.5 mg/kg 6 times a week in drinking water) reduces the hepatocarcinogenicity of NDEA.
R V, Birk +3 more
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Some aspects of prenatal risk of N-nitrosodiethylamine carcinogenesis.
IARC scientific publications, 1981In the respiratory tract of the Syrian golden hamster, N-nitrosodiethylamine (NDEA) tumorigenicity is first observed on the 12th prenatal day. Thereafter, it increases with age. NDEA sensitivity coincides with cellular differentiation of the tissue and with the rapid decline of cellular proliferative activity.
M, Emura +2 more
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