Results 71 to 80 of about 46,645 (191)

Data_Sheet_9_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.zip

, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Haoran Xia (7062632), Jianye Wang (453856), Zhengtong Lv (10146227), Wei Zhang (405), Lingfeng Meng (2576632), Meng Wu (191457), Yaoguang Zhang (746651), Jianlong Wang (438075), Jiawen Wang (350508), Jingchao Liu (2051245)   +9 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Image_2_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.JPEG

, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Haoran Xia (7062632), Jianye Wang (453856), Zhengtong Lv (10146227), Wei Zhang (405), Lingfeng Meng (2576632), Meng Wu (191457), Yaoguang Zhang (746651), Jianlong Wang (438075), Jiawen Wang (350508), Jingchao Liu (2051245)   +9 more
core   +1 more source

Global profiling of N6‐methyladenosine methylation in maize callus induction

The Plant Genome, 2020
Callus induction is a dedifferentiation process that accompanies a cell fate transition, and epigenetic regulation plays a crucial role in the process.
Xuemei Du, Ting Fang, Yan Liu, Meng Wang, Maosen Zang, Liying Huang, Sihan Zhen, Jie Zhang, Zichen Shi, Guoying Wang, Junjie Fu, Yunjun Liu   +11 more
doaj   +1 more source

Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4

Nature Communications, 2022
Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis.
Qiang Luo, Jiezhen Mo, Hao Chen, Zetao Hu, Baihui Wang, Jiabing Wu, Ziyu Liang, Wenhao Xie, Kangxi Du, Maolin Peng, Yingping Li, Tianyang Li, Yangyi Zhang, Xiaoyan Shi, Wen-Hui Shen, Yang Shi, Aiwu Dong, Hailin Wang, Jinbiao Ma   +18 more
doaj   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Data_Sheet_11_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.ZIP

, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Haoran Xia (7062632), Jianye Wang (453856), Zhengtong Lv (10146227), Wei Zhang (405), Lingfeng Meng (2576632), Meng Wu (191457), Yaoguang Zhang (746651), Jianlong Wang (438075), Jiawen Wang (350508), Jingchao Liu (2051245)   +9 more
core   +1 more source

Epigenetic Regulation of m6A Modifications in Human Cancer

Molecular Therapy: Nucleic Acids, 2020
N6-methyladenosine (m6A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m6A modifications of RNA regulate splicing, translocation, stability, and translation into proteins.
Wei Zhao, Xiaoqian Qi, Lina Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +5 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Data_Sheet_12_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.ZIP

, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Haoran Xia (7062632), Jianye Wang (453856), Zhengtong Lv (10146227), Wei Zhang (405), Lingfeng Meng (2576632), Meng Wu (191457), Yaoguang Zhang (746651), Jianlong Wang (438075), Jiawen Wang (350508), Jingchao Liu (2051245)   +9 more
core   +1 more source