Results 1 to 10 of about 28,700 (263)

N6-methyladenosine in DNA promotes genome stability [PDF]

eLife
DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a ...
Brooke A Conti, Leo Novikov, Deyan Tong, Qing Xiang, Savon Vigil, Thomas J McLellan, Chuong Nguyen, Nancy De La Cruz, Reshma T Veettil, Prashant Pradhan, Parag Sahasrabudhe, Jason D Arroyo, Lei Shang, Benjamin R Sabari, David J Shields, Mariano Oppikofer   +15 more
doaj   +2 more sources

N6‐Methyladenosine‐Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification [PDF]

Advanced Science
Lumbar instability causes cartilage endplate ossification and intervertebral disc degeneration. In this study, it is determined that circSMAD4, a Yap1‐related circRNA, is stably downregulated under abnormal stress.
Hanwen Li, Yingchuang Tang, Sihan Hu, Xingbang Ruan, Junxin Zhang, Yihan Shi, Liang Qiu, Huilin Yang, Kai Zhang, Hao Chen, Kangwu Chen   +10 more
doaj   +2 more sources

N6-methyladenosine RNA methylation: From regulatory mechanisms to potential clinical applications

Frontiers in Cell and Developmental Biology, 2022
Epitranscriptomics has emerged as another level of epigenetic regulation similar to DNA and histone modifications. N6-methyladenosine (m6A) is one of the most prevalent and abundant posttranscriptional modifications, widely distributed in many biological
Peipei Li, Peipei Li, Yuntao Wang, Yiwen Sun, Sanjie Jiang, Jingjing Li   +5 more
doaj   +1 more source

One Stone, Two Birds: N6-Methyladenosine RNA Modification in Leukemia Stem Cells and the Tumor Immune Microenvironment in Acute Myeloid Leukemia

Frontiers in Immunology, 2022
Acute myeloid leukemia is the most common acute leukemia in adults, with accumulation of abundant blasts and impairment of hematogenic function. Despite great advances in diagnosis and therapy, the overall survival of patients with acute myeloid leukemia
Xianfeng Ouyang, Xianfeng Ouyang, Yuping Gong   +2 more
doaj   +1 more source

RNA methylation in vascular disease: a systematic review

Journal of Cardiothoracic Surgery, 2022
Despite the rise in morbidity and mortality associated with vascular diseases, the underlying pathophysiological molecular mechanisms are still unclear.
Yue Shu, Yilong Guo, Yin Zheng, Shuwu He, Zhensu Shi   +4 more
doaj   +1 more source

Acetaminophen changes the RNA m6A levels and m6A-related proteins expression in IL-1β-treated chondrocyte cells

BMC Molecular and Cell Biology, 2022
Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown.
Jie Gao, Yan Li, Zijin Liu, Dong Wang, Huawu Zhang   +4 more
doaj   +1 more source

RNA N6-methyladenosine: a promising molecular target in metabolic diseases

Cell & Bioscience, 2020
N6-methyladenosine is a prevalent and abundant transcriptome modification, and its methylation regulates the various aspects of RNAs, including transcription, translation, processing and metabolism.
Yan Li, Jiawen Wang, Chunyan Huang, Meng Shen, Huakui Zhan, Keyang Xu   +5 more
doaj   +1 more source

Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer

Cancer Biology & Medicine, 2020
The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability.
Zhixian Liang, Reilly L. Kidwell, Haijing Deng, Qi Xie   +3 more
doaj   +1 more source

Epigenetic regulation of N6‐methyladenosine modifications in obesity

Journal of Diabetes Investigation, 2021
Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases ...
Mingli Sun, Xinan Zhang
doaj   +1 more source

N6-methyladenosine methylation in kidney injury

Clinical Epigenetics, 2023
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed.
Qimeng Wang, Xiaoting Fan, Qinghao Sheng, Meilin Yang, Ping Zhou, Shangwei Lu, Ying Gao, Zhijuan Kong, Ning Shen, Zhimei Lv, Rong Wang   +10 more
doaj   +1 more source