Results 1 to 10 of about 17,313 (241)

Role of N6‐methyladenosine RNA modification in cancer [PDF]

MedComm
N6‐methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells. Previous studies have shown that m6A is pivotal in diverse diseases especially cancer.
Yi Qu, Nannan Gao, Shengwei Zhang, Limin Gao, Bing He, Chao Wang, Chunli Gong, Qiuyue Shi, Zhibin Li, Shiming Yang, Yufeng Xiao   +10 more
doaj   +4 more sources

N6-methyladenosine in DNA promotes genome stability [PDF]

eLife
DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a ...
Brooke A Conti, Leo Novikov, Deyan Tong, Qing Xiang, Savon Vigil, Thomas J McLellan, Chuong Nguyen, Nancy De La Cruz, Reshma T Veettil, Prashant Pradhan, Parag Sahasrabudhe, Jason D Arroyo, Lei Shang, Benjamin R Sabari, David J Shields, Mariano Oppikofer   +15 more
doaj   +3 more sources

N6-methyladenosine methylation in kidney injury

Clinical Epigenetics, 2023
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed.
Qimeng Wang, Xiaoting Fan, Qinghao Sheng, Meilin Yang, Ping Zhou, Shangwei Lu, Ying Gao, Zhijuan Kong, Ning Shen, Zhimei Lv, Rong Wang   +10 more
doaj   +3 more sources

Functions of N6-methyladenosine and its role in cancer [PDF]

Molecular Cancer, 2019
AbstractN6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis.
Liuer He, Huiyu Li, Anqi Wu, Yulong Peng, Guang Shu, Gang Yin   +5 more
openalex   +5 more sources

Epigenetic regulation of N6‐methyladenosine modifications in obesity [PDF]

Journal of Diabetes Investigation, 2021
Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases ...
Mingli Sun, Xinan Zhang
doaj   +4 more sources

Role of N6-methyladenosine in tumor neovascularization. [PDF]

Cell Death Dis
AbstractTumor neovascularization is essential for the growth, invasion, and metastasis of tumors. Recent studies have highlighted the significant role of N6-methyladenosine (m6A) modification in regulating these processes. This review explores the mechanisms by which m6A influences tumor neovascularization, focusing on its impact on angiogenesis and ...
Zhao L, Li Q, Zhou T, Liu X, Guo J, Fang Q, Cao X, Geng Q, Yu Y, Zhang S, Deng T, Wang X, Jiao Y, Zhang M, Liu H, Tan H, Xiao C.   +16 more
europepmc   +4 more sources

N6-Methyladenosine and Viral Infection [PDF]

Frontiers in Microbiology, 2019
N6-methyladenosine (m6A), as a dynamic posttranscriptional RNA modification, recently gave rise to the field of viral epitranscriptomics. The interaction between virus and host is affected by m6A. Multiple m6A-modified viral RNAs have been observed.
Wei Dang, Wei Dang, Yan Xie, Yan Xie, Pengfei Cao, Shuyu Xin, Jia Wang, Jia Wang, Shen Li, Yanling Li, Jianhong Lu, Jianhong Lu   +11 more
doaj   +3 more sources

Regulatory effect of N6-methyladenosine on tumor angiogenesis. [PDF]

Front Immunol
Previous studies have demonstrated that genetic alterations governing epigenetic processes frequently drive tumor development and that modifications in RNA may contribute to these alterations. In the 1970s, researchers discovered that N6-methyladenosine (m6A) is the most prevalent form of RNA modification in advanced eukaryotic messenger RNA (mRNA) and
YuYan, Yuan E.
europepmc   +4 more sources

The role of N6-methyladenosine modification in tumor angiogenesis. [PDF]

Front Oncol
Tumor angiogenesis is a characteristics of malignant cancer progression that facilitates cancer cell growth, diffusion and metastasis, and has an indispensable role in cancer development. N6-methyladenosine (m6A) is among the most prevalent internal modifications in eukaryotic RNAs, and has considerable influence on RNA metabolism, including its ...
Qin L, Zeng X, Qiu X, Chen X, Liu S.
europepmc   +3 more sources

Function of N6-Methyladenosine Modification in Tumors [PDF]

Journal of Oncology, 2021
N6-Methyladenosine (m6A) modification is a dynamic and reversible methylation modification at the N6-position of adenosine. As one of the most prevalent posttranscriptional methylation modifications of RNA, m6A modification participates in several mRNA processes, including nuclear export, splicing, translation, and degradation.
Nan Zhang, Yuxin Zuo, Yu Peng, Lielian Zuo   +3 more
openaire   +3 more sources