Results 11 to 20 of about 17,313 (241)

N6-methyladenosine RNA methylation: From regulatory mechanisms to potential clinical applications

Frontiers in Cell and Developmental Biology, 2022
Epitranscriptomics has emerged as another level of epigenetic regulation similar to DNA and histone modifications. N6-methyladenosine (m6A) is one of the most prevalent and abundant posttranscriptional modifications, widely distributed in many biological
Peipei Li, Peipei Li, Yuntao Wang, Yiwen Sun, Sanjie Jiang, Jingjing Li   +5 more
doaj   +1 more source

One Stone, Two Birds: N6-Methyladenosine RNA Modification in Leukemia Stem Cells and the Tumor Immune Microenvironment in Acute Myeloid Leukemia

Frontiers in Immunology, 2022
Acute myeloid leukemia is the most common acute leukemia in adults, with accumulation of abundant blasts and impairment of hematogenic function. Despite great advances in diagnosis and therapy, the overall survival of patients with acute myeloid leukemia
Xianfeng Ouyang, Xianfeng Ouyang, Yuping Gong   +2 more
doaj   +1 more source

RNA methylation in vascular disease: a systematic review

Journal of Cardiothoracic Surgery, 2022
Despite the rise in morbidity and mortality associated with vascular diseases, the underlying pathophysiological molecular mechanisms are still unclear.
Yue Shu, Yilong Guo, Yin Zheng, Shuwu He, Zhensu Shi   +4 more
doaj   +1 more source

Function and evolution of RNA N6-methyladenosine modification [PDF]

International Journal of Biological Sciences, 2020
N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers),
Zhi-Man Zhu, Dong-Sheng Pei, Fu-Chun Huo
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circRNA N6-methyladenosine methylation in preeclampsia and the potential role of N6-methyladenosine-modified circPAPPA2 in trophoblast invasion

Scientific Reports, 2021
AbstractHere, we performed N6-methyladenosine (m6A) RNA sequencing to determine the circRNA m6A methylation changes in the placentas during the pathogenesis of preeclampsia (PE). We verified the expression of the circRNA circPAPPA2 using quantitative reverse transcription-PCR.
Yonggang Zhang, Hongling Yang, Yan Long, Yipeng Zhang, Ronggui Chen, Junzhu Shi, Jiying Chen   +6 more
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Acetaminophen changes the RNA m6A levels and m6A-related proteins expression in IL-1β-treated chondrocyte cells

BMC Molecular and Cell Biology, 2022
Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown.
Jie Gao, Yan Li, Zijin Liu, Dong Wang, Huawu Zhang   +4 more
doaj   +1 more source

Insights into the role of N6-methyladenosine in ferroptosis

Biomedicine & Pharmacotherapy, 2023
N6-methyladenosine (m6A) methylation modification is one of the most prevalent epigenetic modifications of eukaryotic RNA. m6A methylation is widely associated with many biological processes through the modification of RNA metabolism and is associated with multiple disease states. As a newly discovered regulatory cell death in recent years, ferroptosis
Jingyuan, Zhang, Tianming, Qiu, Xiaofeng, Yao, Xiance, Sun   +3 more
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Role of N6-methyladenosine Modification in Cardiac Remodeling [PDF]

Frontiers in Cardiovascular Medicine, 2022
Cardiac remodeling is the critical process in heart failure due to many cardiovascular diseases including myocardial infarction, hypertension, cardiovascular disease and cardiomyopathy. However, treatments for heart failure focusing on cardiac remodeling show relatively limited effectiveness.
ManTing Choy, ManTing Choy, Ruicong Xue, Ruicong Xue, Yuzhong Wu, Yuzhong Wu, Wendong Fan, Wendong Fan, Yugang Dong, Yugang Dong, Chen Liu, Chen Liu   +11 more
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RNA N6-methyladenosine: a promising molecular target in metabolic diseases

Cell & Bioscience, 2020
N6-methyladenosine is a prevalent and abundant transcriptome modification, and its methylation regulates the various aspects of RNAs, including transcription, translation, processing and metabolism.
Yan Li, Jiawen Wang, Chunyan Huang, Meng Shen, Huakui Zhan, Keyang Xu   +5 more
doaj   +1 more source

The functions of N6-methyladenosine modification in lncRNAs

Genes & Diseases, 2020
Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA.
Jing Jiang, Dixian Luo, Rong-Zhang He, Rong-Zhang He   +3 more
openaire   +4 more sources