Results 11 to 20 of about 28,700 (263)

Role of N6-methyladenosine methylation in transverse aortic constriction-induced cardiac fibrosis: insights from MeRIP-seq analysis. [PDF]

Mol Biol Rep
Liu S, Liu H, Bai Q, Wei Z, Zhao P, Chen H, Song B, Yu C.   +7 more
europepmc   +3 more sources

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]

, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J., Gould, Peter D., Hall, Anthony J. W., Knop, Katarzyna, Mackinnon, Katarzyna, Parker, Matthew T., Schurch, Nicholas J., Sherwood, Anna V., Simpson, Gordon G.   +8 more
core   +3 more sources

N6 -Methyladenosine Negatively Regulates Human Respiratory Syncytial Virus Replication

Frontiers in Cell and Developmental Biology, 2021
N6-methyladenosine (m6A) is the most abundant internal modification described in eukaryotic mRNA and several viral RNA including human respiratory syncytial virus (HRSV).
Fabian Figueroa, Alonso Vega-Gibson, Joseline Catrileo, Aracelly Gaete-Argel, Aracelly Gaete-Argel, Sebastian Riquelme-Barrios, Sebastian Riquelme-Barrios, Luis Antonio Alonso-Palomares, Luis Antonio Alonso-Palomares, Lorena I. Tapia, Lorena I. Tapia, Fernando Valiente-Echeverría, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Ricardo Soto-Rifo, Monica L. Acevedo   +15 more
doaj   +1 more source

N6‐methyladenosine Steers RNA Metabolism and Regulation in Cancer

Cancer Communications, 2021
As one of the most studied ribonucleic acid (RNA) modifications in eukaryotes, N6‐methyladenosine (m6A) has been shown to play a predominant role in controlling gene expression and influence physiological and pathological processes such as oncogenesis ...
Shenghua Dong, Yutong Wu, Yadi Liu, Hengyou Weng, Huilin Huang   +4 more
doaj   +1 more source

FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review

Frontiers in Oncology, 2023
Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis. Therefore, developing novel effective markers and therapeutic targets for gastrointestinal cancer is currently a challenging and popular topic in oncology research ...
Xiangqing Ren, Xiangqing Ren, Xiangqing Ren, Xiaolong Tang, Tian Huang, Tian Huang, Tian Huang, Zenan Hu, Zenan Hu, Yuping Wang, Yuping Wang, Yongning Zhou, Yongning Zhou   +12 more
doaj   +1 more source

ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner

Experimental Hematology & Oncology, 2023
Background N6-methyladenosine (m6A) is a prevalent modification of mRNA and is known to play important roles in tumorigenesis in many types of cancer. The function of N6-methyladenosine (m6A) RNA methylation depends on a variety of methyltransferases and
Weijian Wang, Qibo Huang, Zhibin Liao, Hongwei Zhang, Yachong Liu, Furong Liu, Xiaoping Chen, Bixiang Zhang, Yan Chen, Peng Zhu   +9 more
doaj   +1 more source

Fat mass and obesity-associated protein downregulation enhances N6-methyladenosine methylation and drives ovarian cancer progression. [PDF]

J Cell Commun Signal
FTO downregulation elevates global m6A methylation, enhancing ovarian cancer malignancy. Bioinformatics and experimental analyses revealed that the fat mass and obesity‐associated protein (FTO) was significantly downregulated in ovarian cancer tissues and cell lines.
Wang X, Wu D, Li C, Du X.
europepmc   +2 more sources

m6a RNA methylation: the implications for health and disease [PDF]

, 2014
The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
core   +1 more source

Roles and implications of mRNA N6‐methyladenosine in cancer

Cancer Communications, 2023
RNA N6‐methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased attention.
Lingxing Zeng, Xudong Huang, Jialiang Zhang, Dongxin Lin, Jian Zheng   +4 more
doaj   +1 more source

METTL3 regulates WTAP protein homeostasis [PDF]

, 2018
The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina, Cruciani, Sonia, Fatica, Alessandro, Fazi, Francesco, Ginistrelli, Lavinia Ceci, Ianniello, Zaira, Larivera, Simone, Marchioni, Marcella, Sorci, Melissa   +8 more
core   +2 more sources