Liver-specific Mettl3 ablation delays liver regeneration in mice
Genes and Diseases, 2022 This study investigated the role of N6-methyladenosine RNA methylation in liver regeneration following partial hepatectomy in mice. We created a liver-specific knockout mouse model by the deletion of Mettl3, a key component of the N6-methyladenosine ...
Jiaxiang Meng +3 more
doaj +1 more source
Chondrocytes respond to adenosine via A2receptors and activity is potentiated by an adenosine deaminase inhibitor and a phosphodiesterase inhibitor [PDF]
, 2002 Objective To test the mechanisms by which adenosine and adenosine analogues stimulate adenylate cyclase and suppress lipopolysaccharide (LPS)-induced production of nitric oxide (NO) by chondrocytes.Methods Primary chondrocytes isolated from equine ...
Tesch, A.M. +3 more
core +1 more source
Effect of methylation of adenine N6 on kink turn structure depends on location [PDF]
, 2019 N6-methyladenine is the most common covalent modification in cellular RNA species, with demonstrated functional consequences. At the molecular level this methylation could alter local RNA structure, and/or modulate the binding of specific proteins.
Bokar JA +3 more
core +2 more sources
Chinese Medicine, 2021 Background Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied.
Zhizhen Song +4 more
doaj +1 more source
RNA Sequencing Reveals the Regulation of Betaine on Chicken Myogenesis
Animals, 2022 Betaine is trimethylglycine and a universal methyl donor which could provide methyl and glycine for cells and animals. As a new star in epigenetics, N6-Methyladenosine has been reported to regulate multiple biological activities, but the regulatory ...
Zhijun Wang +6 more
doaj +1 more source
The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. [PDF]
, 2017 YTHDF2 binds and destabilizes N6-methyladenosine (m6A)-modified mRNA. The extent to which this branch of m6A RNA-regulatory pathway functions in vivo and contributes to mammalian development remains unknown.
Azzi, Chiara +9 more
core +3 more sources
FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
Nature Communications, 2021 The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am ...
Sébastien Relier +21 more
doaj +1 more source
N6-Methyladenosine Modification of circIST1 Promotes Hypoxia-Inducible Factor α-mediated Glycolysis and Progression in Hepatocellular Carcinoma. [PDF]
MedComm (2020)We identified first time a critical m6A modification of circIST1 on miR‐140‐3p/miR‐182‐HIF1α regulatory network involved in the HCC progression and tumor glycolysis, gaining mechanistic insights into the function of circRNAs in HCC progression. ABSTRACT The involvement of circular RNAs (circRNAs) have been well‐documented in various cancers, including ...
Zhan Y +12 more
europepmc +2 more sources
Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment [PDF]
, 2015 Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO’s (Fat Mass Obesity) N6-methyladenosine (m6 A) deaminase activity, thus suggesting a link between obesity ...
Archer, Nathan +5 more
core +3 more sources
The importance of N6-methyladenosine modification in tumor immunity and immunotherapy
Experimental Hematology & Oncology, 2022 As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor.
Ze Zhang +8 more
doaj +1 more source