Results 21 to 30 of about 17,313 (241)

Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer

Cancer Biology & Medicine, 2020
The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability.
Zhixian Liang, Reilly L. Kidwell, Haijing Deng, Qi Xie   +3 more
doaj   +1 more source

N6-Methyladenosine RNA Methylation in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2022
N6-methyladenosine (m6A) modification is the most universal and abundant post-transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR (m6A) CH (R = A or G, H = A, C, or U) in long internal exons, near stop codons, or in the 3′ untranslated region (UTR).
Chi Liu, Chi Liu, Lei Gu, Wenjuan Deng, Qianchao Meng, Nan Li, Guifeng Dai, Suli Yu, Hong Fang   +8 more
openaire   +3 more sources

HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia

Cancer Medicine, Volume 11, Issue 24, Page 5050-5065, December 2022., 2022
The aberrant expression pattern and prognostic implications of HIVEP3 in AML were explored and validated based on versatile bioinformatics tools. A LASSO model which combined HIVEP3 with ferroptosis regulators was created to predict the prognosis for AML patients.
Xiaoning Zhang, Xiaoyu Zhang, Kuo Liu, Wenwen Li, Jiazheng Wang, Peng Liu, Wanshan Ma   +6 more
wiley   +1 more source

FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review

Frontiers in Oncology, 2023
Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis. Therefore, developing novel effective markers and therapeutic targets for gastrointestinal cancer is currently a challenging and popular topic in oncology research ...
Xiangqing Ren, Xiangqing Ren, Xiangqing Ren, Xiaolong Tang, Tian Huang, Tian Huang, Tian Huang, Zenan Hu, Zenan Hu, Yuping Wang, Yuping Wang, Yongning Zhou, Yongning Zhou   +12 more
doaj   +1 more source

Roles and implications of mRNA N6‐methyladenosine in cancer

Cancer Communications, 2023
RNA N6‐methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased attention.
Lingxing Zeng, Xudong Huang, Jialiang Zhang, Dongxin Lin, Jian Zheng   +4 more
doaj   +1 more source

Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer

Frontiers in Medicine, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Jingchao Liu, Jingchao Liu, Jianlong Wang, Meng Wu, Wei Zhang, Wei Zhang, Lingfeng Meng, Lingfeng Meng, Jiawen Wang, Jiawen Wang, Zhengtong Lv, Zhengtong Lv, Haoran Xia, Haoran Xia, Yaoguang Zhang, Yaoguang Zhang, Jianye Wang, Jianye Wang   +17 more
doaj   +1 more source

N6-methyladenosine marks primary microRNAs for processing [PDF]

Nature, 2015
The first step in the biogenesis of microRNAs is the processing of primary microRNAs (pri-miRNAs) by the microprocessor complex, composed of the RNA-binding protein DGCR8 and the type III RNase DROSHA. This initial event requires recognition of the junction between the stem and the flanking single-stranded RNA of the pri-miRNA hairpin by DGCR8 followed
Alarcón, Claudio R, Lee, Hyeseung, Goodarzi, Hani, Halberg, Nils, Tavazoie, Sohail F   +4 more
openaire   +4 more sources

N6‐methyladenosine Steers RNA Metabolism and Regulation in Cancer

Cancer Communications, 2021
As one of the most studied ribonucleic acid (RNA) modifications in eukaryotes, N6‐methyladenosine (m6A) has been shown to play a predominant role in controlling gene expression and influence physiological and pathological processes such as oncogenesis ...
Shenghua Dong, Yutong Wu, Yadi Liu, Hengyou Weng, Huilin Huang   +4 more
doaj   +1 more source

N6-Methyladenosine-Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification. [PDF]

Adv Sci (Weinh)
Lumbar instability mediates cartilage endplate degeneration with YAP translocation and stability. Here, it is determined that circSMAD4, a Yap1‐related circRNA, is shown to combine and regulate Yap1 mRNA through the formation of the ternary complexes with the m6A reader IGF2BP1.
Li H, Tang Y, Hu S, Ruan X, Zhang J, Shi Y, Qiu L, Yang H, Zhang K, Chen H, Chen K.   +10 more
europepmc   +2 more sources

miR‐96‐5p regulates cervical cancer cell resistance to cisplatin by inhibiting lncRNA TRIM52‐AS1 and promoting IGF2BP2

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1178-1189, December 2022., 2022
Abstract MicroRNA (miRNA) and long noncoding RNA (lncRNA) are both regulators of cancer progression. This study sought to discuss the functional mechanism of miR‐96‐5p/lncRNA TRIM52 antisense RNA 1 (head‐to‐head; TRIM52‐AS1) in cervical cancer (CC) cell resistance to cisplatin (DDP).
En Yuesu Wu, Li‐Ping Huang, Jin‐Hua Bao   +2 more
wiley   +1 more source