Results 31 to 40 of about 17,313 (241)

ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner

Experimental Hematology & Oncology, 2023
Background N6-methyladenosine (m6A) is a prevalent modification of mRNA and is known to play important roles in tumorigenesis in many types of cancer. The function of N6-methyladenosine (m6A) RNA methylation depends on a variety of methyltransferases and
Weijian Wang, Qibo Huang, Zhibin Liao, Hongwei Zhang, Yachong Liu, Furong Liu, Xiaoping Chen, Bixiang Zhang, Yan Chen, Peng Zhu   +9 more
doaj   +1 more source

N6 -Methyladenosine Negatively Regulates Human Respiratory Syncytial Virus Replication

Frontiers in Cell and Developmental Biology, 2021
N6-methyladenosine (m6A) is the most abundant internal modification described in eukaryotic mRNA and several viral RNA including human respiratory syncytial virus (HRSV).
Fabian Figueroa, Alonso Vega-Gibson, Joseline Catrileo, Aracelly Gaete-Argel, Aracelly Gaete-Argel, Sebastian Riquelme-Barrios, Sebastian Riquelme-Barrios, Luis Antonio Alonso-Palomares, Luis Antonio Alonso-Palomares, Lorena I. Tapia, Lorena I. Tapia, Fernando Valiente-Echeverría, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Ricardo Soto-Rifo, Monica L. Acevedo   +15 more
doaj   +1 more source

Impact of N6-methyladenosine (m6A) modification on immunity

Cell Communication and Signaling, 2022
AbstractN6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels.
Raghda A. Elsabbagh, Mona Rady, Carsten Watzl, Khaled Abou-Aisha, Mohamed Z. Gad   +4 more
openaire   +4 more sources

Emerging Roles of N6-Methyladenosine Modification in Neurodevelopment and Neurodegeneration [PDF]

Cells, 2021
N6-methyladenosine (m6A), the most abundant modification in messenger RNAs (mRNAs), is deposited by methyltransferases (“writers”) Mettl3 and Mettl14 and erased by demethylases (“erasers”) Fto and Alkbh5. m6A can be recognized by m6A-binding proteins (“readers”), such as Yth domain family proteins (Ythdfs) and Yth domain-containing protein 1 (Ythdc1 ...
Xiaoli Huang, Xuejun Cheng, Liqi Shu, Xuekun Li   +3 more
openaire   +4 more sources

Role of RNA modifications in carcinogenesis and carcinogen damage response

Molecular Carcinogenesis, Volume 62, Issue 1, Page 24-37, January 2023., 2023
Abstract The field of epitranscriptomics encompasses the study of post‐transcriptional RNA modifications and their regulatory enzymes. Among the numerous RNA modifications, N6‐methyladenosine (m6A) has been identified as the most common internal modification of messenger RNA (mRNA).
Michelle Verghese, Emma Wilkinson, Yu‐Ying He   +2 more
wiley   +1 more source

Regulation of N6-Methyladenosine after Myocardial Infarction

Cells, 2022
Development of heart failure (HF) after myocardial infarction (MI) is responsible for premature death. Complex cellular and molecular mechanisms are involved in this process. A number of studies have linked the epitranscriptomic RNA modification N6-methyladenosine (m6A) with HF, but it remains unknown how m6A affects the risk of developing HF after MI.
Mélanie Vausort, Magdalena Niedolistek, Andrew I. Lumley, Marta Oknińska, Aleksandra Paterek, Michał Mączewski, Xiangyi Dong, Christian Jäger, Carole L. Linster, Przemyslaw Leszek, Yvan Devaux   +10 more
openaire   +3 more sources

Benchmark data for identifying N6-methyladenosine sites in the Saccharomyces cerevisiae genome

Data in Brief, 2015
This data article contains the benchmark dataset for training and testing iRNA-Methyl, a web-server predictor for identifying N6-methyladenosine sites in RNA (Chen et al., 2015 [15]).
Wei Chen, Pengmian Feng, Hui Ding, Hao Lin, Kuo-Chen Chou   +4 more
doaj   +1 more source

UPLC-MS/MS method for simultaneously determining nucleosides and methyl-nucleosides in liver mRNA of Epimedin C-induced liver injury mouse model

Chinese Medicine, 2021
Background Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied.
Zhizhen Song, Zeyun Li, Xueqian Wen, Ruijuan Liu, Xin Tian   +4 more
doaj   +1 more source

N6-Methyladenosine Role in Acute Myeloid Leukaemia [PDF]

International Journal of Molecular Sciences, 2018
We are currently assisting in the explosion of epitranscriptomics, which studies the functional role of chemical modifications into RNA molecules. Among more than 100 RNA modifications, the N6-methyladenosine (m6A), in particular, has attracted the interest of researchers all around the world.
Ianniello, Zaira, Fatica, Alessandro
openaire   +4 more sources

RNA Sequencing Reveals the Regulation of Betaine on Chicken Myogenesis

Animals, 2022
Betaine is trimethylglycine and a universal methyl donor which could provide methyl and glycine for cells and animals. As a new star in epigenetics, N6-Methyladenosine has been reported to regulate multiple biological activities, but the regulatory ...
Zhijun Wang, Danfeng Cai, Xing Ju, Kan Li, Sisi Liang, Meixia Fang, Qinghua Nie   +6 more
doaj   +1 more source