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N6‐methyladenosine (m6A) Modification in Preeclampsia
Reproductive Sciences, 2023Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification.
Tingting Zhang +6 more
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N6‐methyladenosine (m6A) modification in gynecological malignancies
Journal of Cellular Physiology, 2022AbstractN6‐methyladenosine (m6A) modification is one of the most abundant modifications in eukaryotic mRNA, regulated by m6A methyltransferase and demethylase. m6A modified RNA is specifically recognized and bound by m6A recognition proteins, which mediate splicing, maturation, exonucleation, degradation, and translation.
Chunmei Zhang, Ning Liu
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The role of N6-methyladenosine (m6A) in eye diseases
Molecular Biology Reports, 2021N6-methyladenosine (m6A) is the most common form of internal RNA modification in eukaryotes. The dynamic regulation of m6A modification mainly rely on three proteases, installed by m6A methyltransferase, removed by m6A demethylase and recognized by m6A reader protein, which regulates the metabolism of RNA, thereby regulating the processes of cell ...
Jing-Fan Gao, Lu Zhang
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Advances in the profiling of N6-methyladenosine (m6A) modifications
Biotechnology Advances, 2020Over 160 RNA modifications have been identified, including N7-methylguanine (m7G), N6-methyladenosine (m6A), and 5-methylcytosine (m5C). These modifications play key roles in regulating the fate of RNA. In eukaryotes, m6A is the most abundant mRNA modification, accounting for over 80% of all RNA methylation modifications.
Hong-Xiang, Zheng +2 more
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The functions of N6-methyladenosine (m6A) RNA modifications in colorectal cancer
Medical Oncology, 2022Colorectal cancers (CRC), which includes colon cancer (CC) and rectal cancer (RC), are some of the most common malignant tumors that are prone to distant metastasis. Its high incidence rate and high mortality rate have attracted much attention. In recent years, epigenetics has attracted increasing attention and has been the focus of many research ...
Haiyan Qiao +4 more
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Importance of m N6-methyladenosine (m6A) RNA modification in cancer
Medical Oncology, 2019RNA methylation, which was identified back in 1970s, has gained remarkable interest in recent years as it was shown to be a reversible modification involved in many cellular processes like mRNA and miRNA processing, mRNA localisation, translation suppression, or activation.
Gulten Tuncel, Rasime Kalkan
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RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential
Cancer Gene Therapy, 2023Head and neck squamous cell carcinoma ranks seventh in incidence of malignant tumours in the world. Although there are treatments including surgery, radiotherapy and chemotherapy, targeted therapy and immunotherapy, drug resistance to treatment is caused by various reasons, and the survival rate of patients remains frustrating.
Xinyu, Sun +6 more
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Regulation of m6A (N6-Methyladenosine) methylation modifiers in solid cancers
Functional & Integrative GenomicsSolid cancers constitute a tremendous burden on global healthcare, requiring a deeper understanding of the molecular mechanisms underlying cancer development and progression. Epigenetic changes, notably N6-methyladenosine (m6A) RNA methylation, have emerged as important contributors to the biology of solid tumors in recent years.
Sakshi, Singh +3 more
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Paraquat-induced oxidative stress regulates N6-methyladenosine (m6A) modification of circular RNAs
Environmental Pollution, 2021Paraquat (PQ), a widely used herbicide and well-known oxidative stress inducer, has been linked to numerous neurodegenerative diseases, but the underlying mechanism(s) remains unknown. Circular RNAs (circRNAs) have recently been reported to be associated with oxidative stress in Parkinson's disease.
Nengzhou Chen +9 more
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N6-methyladenosine (m6A) modification: Emerging regulators in plant-virus interactions
VirologyN6-methyladenosine (m6A), a reversible epigenetic modification, is widely present on both cellular and viral RNAs. This modification undergoes catalysis by methyltransferases (writers), removal by demethylases (erasers), and recognition by m6A-binding proteins (readers), ultimately influencing the fate and function of modified RNA molecules.
Yanjun Li, Jianping Chen, Zongtao Sun
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