METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice
Nature Communications, 2020 N6-methyladenosine (m6A) is one of the most prevalent mRNA modifications in eukaryotes. Here the authors show that the m6A writer protein methyltransferase-like (METTL) 3 plays an important role for the development of brown adipose tissue.
Yuqin Wang +8 more
doaj +1 more source
Insights into the Molecular Mechanisms of the N6-Methyladenosine (m6A) Methylation Machinery in the Regulation of the Infection Cycle of RNA Plant Viruses [PDF]
, 2022 [ES] La N6-metiladenosina (m6A) es una modificación generalizada en los ARN celulares de diferentes organismos que puede afectar muchos procesos y vías celulares.
Alvarado Marchena, Luis Fernando
core +1 more source
Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment [PDF]
, 2015 Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO’s (Fat Mass Obesity) N6-methyladenosine (m6 A) deaminase activity, thus suggesting a link between obesity ...
Archer, Nathan +5 more
core +3 more sources
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation [PDF]
, 2017 Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and generally uncoupled, despite serving a common purpose.
Agami, R. (Reuven) +6 more
core +4 more sources
Emerging roles of N6-methyladenosine (m6A) modification in breast cancer [PDF]
Cell & Bioscience, 2020 AbstractN6-Methyladenosine (m6A) is the most abundant, dynamic, and reversible epigenetic RNA modification that is found in coding and non-coding RNAs. Emerging studies have shown that m6A and its regulators affect multiple steps in RNA metabolism and play broad roles in various cancers.
Yanyan Wang +5 more
openaire +2 more sources
N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4
Nature Communications, 2020 Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects ...
Zihan Li +7 more
doaj +1 more source
Roles of RNA m6A modifications in plant-virus interactions
Stress Biology, 2023 Viral RNAs have been known to contain N6-methyladenosine (m6A) modifications since the 1970s. The function of these modifications remained unknown until the development of genome-wide methods to map m6A residues. Increasing evidence has recently revealed
Hao He +4 more
doaj +1 more source
The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. [PDF]
, 2017 YTHDF2 binds and destabilizes N6-methyladenosine (m6A)-modified mRNA. The extent to which this branch of m6A RNA-regulatory pathway functions in vivo and contributes to mammalian development remains unknown.
Azzi, Chiara +9 more
core +3 more sources
Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA [PDF]
, 2018 The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss ...
Bian, Ke +8 more
core +1 more source
Functional organization of box C/D RNA-guided RNA methyltransferase [PDF]
, 2020 Box C/D RNA protein complexes (RNPs) catalyze site-specific 2'-O-methylation of RNA with specificity determined by guide RNAs. In eukaryotic C/D RNP, the paralogous Nop58 and Nop56 proteins specifically associate with terminal C/D and internal C'/D ...
Huang, Lin +4 more
core +2 more sources