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Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease [PDF]
Frontiers in Bioscience, 2007 Epidemiological studies have identified a negative correlation between smoking and the development of neurodegenerative disorders such as Parkinson's disease, and in some studies, Alzheimer's disease. These findings have been attributed to the ability of nicotine to act as a neuroprotective agent. A large number of studies demonstrate that nicotine can
Marina R. Picciotto
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Anzeige betreffend den Abonnementspreis der Astr. Nachr. [PDF]
Astronomische Nachrichten, 1907 n ...
H Kreutz
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Editorial: Math. Nachr. 1/2010 [PDF]
Mathematische Nachrichten, 2009 Albrecht Böttcher +2 more
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Sulfonium Ligands of the α7 nAChR [PDF]
Molecules, 2021 The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor are of particular interest.
Nicole A. Horenstein +2 more
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Why Is α4β2 Nachr More Sensitive to Volatile Anesthetics Than α7 Nachr? [PDF]
Biophysical Journal, 2010 Two subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) show different functional sensitivities to volatile anesthetics: the α4β2 nAChR is hypersensitive while the α7 nAChR is insensitive. To understand why these homologous proteins have different functional responses to volatile anesthetics, we performed multiple sets of 20-ns molecular ...
Yan Xu +5 more
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Enriques involutions on pencils of K3 surfaces [PDF]
Math. Nachr. 295 (2022), no. 7, 1312--1326, 2021 The three pencils of K3 surfaces of minimal discriminant whose general element covers at least one Enriques surface are Kond\={o}'s pencils I and II, and the Ap\'ery--Fermi pencil. We enumerate and investigate all Enriques surfaces covered by their general elements.
arxiv +1 more source
Modulation of recombinant, α2*, α3* or α4*‐nicotinic acetylcholine receptor (nAChR) function by nAChR β3 subunits* [PDF]
Journal of Neurochemistry, 2012 J. Neurochem. (2012) 121, 349–361.AbstractThe nicotinic acetylcholine receptor (nAChR) β3 subunit is thought to serve an accessory role in nAChR subtypes expressed in dopaminergic regions implicated in drug dependence and reward. When β3 subunits are expressed in excess, they have a dominant‐negative effect on function of selected nAChR subtypes.
Ronald J. Lukas +3 more
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Function of nAChRs Containing Alpha5 Subunits [PDF]
Biophysical Journal, 2012 Neuronal nicotinic acetylcholine receptors (nAChRs) are abundantly expressed in the central nervous system. Neurons in several brain regions co-express alpha5, alpha4 and beta2 subunits. Changes in the receptor composition and stoichiometry of alpha4 and beta2 containing nAChRs are pertinent to disease states.
Dennis A. Dougherty +3 more
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Progresive Analysis of nAChR Stability in the Lipidic Cubic Phase: nAChR Detergent Solubilization and Fractional Mobility [PDF]
Biophysical Journal, 2014 Nicotinic acetylcholine receptors (nAChRs) are transmembrane receptors, members of the ligand-gated ion channels (LGIC) family, and key component of the neuromuscular junction. On vertebrate they mediate nervous impulse supporting the synaptic mechanism. As a result the nAChR are important targets for the treatment of neurodegenerative diseases such as
Claudia Lanauze +5 more
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Pathophysiology of nAChRs: Limbic circuits and related disorders
Pharmacological Research, 2023 Human epidemiological studies have identified links between nicotine intake and stress disorders, including anxiety, depression and PTSD. Here we review the clinical evidence for activation and desensitization of nicotinic acetylcholine receptors (nAChRs) relevant to affective disorders.
Yann S. Mineur +4 more
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