Results 1 to 10 of about 76,340 (268)

Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets

Marine Drugs, 2019
Nicotinic acetylcholine receptors (nAChRs) are associated with various cancers, but the relation between nAChRs and cervical cancer remains unclear. Therefore, this study investigated the differential expression of nAChR subunits in human cervical cancer
Yiqiao Liu, Jiang Qian, Zhihua Sun, Dongting Zhangsun, Sulan Luo   +4 more
doaj   +1 more source

Nikotinski acetilholinski receptor kot farmakološka tarča pri pljučnem raku

Acta Biologica Slovenica, 2022
Rak pljuč je zelo razširjena oblika raka z nizko stopnjo preživetja. Kajenje tobaka predstavlja glavni dejavnik tveganja za razvoj raka pljuč, saj v tobačnem dimu najdemo veliko rakotvornih snovi.
Veno Kononenko, Tadeja Bele, Sara Novak, Igor Križaj, Damjana Drobne, Tom Turk   +5 more
doaj   +1 more source

From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR

Scientific Reports, 2016
Acetylcholine binding proteins (AChBPs) are unique spatial homologs of the ligand-binding domains of nicotinic acetylcholine receptors (nAChRs), and they reproduce some pharmacological properties of nAChRs.
Bo Lin, Manyu Xu, Xiaopeng Zhu, Yong Wu, Xi Liu, Dongting Zhangsun, Yuanyan Hu, S. Xiang, I. Kasheverov, V. Tsetlin, Xinquan Wang, S. Luo   +11 more
semanticscholar   +1 more source

Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation

Frontiers in Molecular Neuroscience, 2015
Nicotine addiction, the result of tobacco use, leads to over six million premature deaths world-wide, a number that is expected to increase by a third within the next two decades.
Tasnim S. Mohamed, Selwyn S. Jayakar, Ayman K Hamouda   +2 more
doaj   +1 more source

α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension

JCI Insight, 2021
Right ventricular (RV) fibrosis is a key feature of maladaptive RV hypertrophy and dysfunction and is associated with poor outcomes in pulmonary hypertension (PH).
Alexander Vang, Denielli da Silva Gonçalves Bos, Ana Fernandez-Nicolas, Peng Zhang, Alan R. Morrison, Thomas J. Mancini, Richard T. Clements, Iuliia Polina, Michael W. Cypress, Bong Sook Jhun, Edward Hawrot, Ulrike Mende, Jin O-Uchi, Gaurav Choudhary   +13 more
doaj   +1 more source

Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms.

PLoS ONE, 2019
Central nervous system nicotinic acetylcholine receptors (nAChR) are predominantly of the α4β2 subtype. Two isoforms exist, with high or low agonist sensitivity (HS-(α4β2)2β2- and LS-(α4β2)2α4-nAChR). Both isoforms exhibit similar macroscopic potency and
Maegan M Weltzin, Andrew A George, Ronald J Lukas, Paul Whiteaker   +3 more
doaj   +1 more source

Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. [PDF]

PLoS ONE, 2016
Cigarette smoking is the major risk factor for non-small cell lung cancer (NSCLC), which accounts for 80% of all lung cancers. Nicotine, the addictive component of tobacco smoke, can induce proliferation, migration, invasion, epithelial-mesenchymal ...
Courtney Schaal, Srikumar Chellappan
doaj   +1 more source

Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model

Frontiers in Cellular Neuroscience, 2017
Triple-negative breast cancer (TNBC) subtype is associated with poor prognosis and a high risk of recurrence-related death in women. Despite the aggressiveness of TNBCs, targeted TNBC therapy is not yet available in the clinic. To overcome this challenge,
Li-Chi Huang, Ching-Ling Lin, Jia-Zheng Qiu, Chun-Yu Lin, Kai-Wen Hsu, Ka-Wai Tam, Ka-Wai Tam, Ka-Wai Tam, Jung-Yu Lee, Jinn-Moon Yang, Jinn-Moon Yang, Chia-Hwa Lee, Chia-Hwa Lee, Chia-Hwa Lee   +13 more
doaj   +1 more source

Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

Journal of Neuroinflammation, 2017
Background α7 nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system and are reported to have neuroprotective properties.
Hiral Patel, Jessica McIntire, Sarah Ryan, Anthone Dunah, Ralph Loring   +4 more
doaj   +1 more source

Recombinant Newcastle disease virus rL-RVG enhances the apoptosis and inhibits the migration of A549 lung adenocarcinoma cells via regulating alpha 7 nicotinic acetylcholine receptors in vitro

Virology Journal, 2017
Background The aim of this study were to investigate the possible pro-apoptotic mechanisms of the recombinant Newcastle disease virus (NDV) strain rL-RVG, which expresses the rabies virus glycoprotein, in A549 lung adenocarcinoma cells via the regulation
Yulan Yan, Chunxiang Su, Min Hang, Hua Huang, Yinghai Zhao, Xiaomei Shao, Xuefeng Bu   +6 more
doaj   +1 more source