Results 11 to 20 of about 2,824 (121)
Identification of Molluscan Nicotinic Acetylcholine Receptor (nAChR) Subunits Involved in Formation of Cation- and Anion-Selective nAChRs [PDF]
The Journal of Neuroscience, 2005 Acetylcholine (ACh) is a neurotransmitter commonly found in all animal species. It was shown to mediate fast excitatory and inhibitory neurotransmission in the molluscan CNS. Since early intracellular recordings, it was shown that the receptors mediating these currents belong to the family of neuronal nicotinic acetylcholine receptors and that they can
van Nierop, Pim +6 more
openaire +4 more sources
Varenicline Blocks 2*-nAChR-Mediated Response and Activates 4*-nAChR-Mediated Responses in Mice In Vivo [PDF]
Nicotine & Tobacco Research, 2012 The smoking cessation aid, varenicline, has higher affinity for the alpha4beta2-subtype of the nicotinic acetylcholine receptor (α4β2*-nAChR) than for other subtypes of nAChRs by in vitro assays. The mechanism of action of acute varenicline was studied in vivo to determine (a) subtype activation associated with physiological effects and (b) dose ...
Sharon R. Grady +3 more
openaire +3 more sources
Selective correlation of nAChRs and DAT
The FASEB Journal, 2012 Nicotine has been shown to regulate the dopamine transporter (DAT) in a tissue dependent manner and to affect increase both the function of DAT as well as its surface expression (Middleton et al., 2004; Zhu et al., 2009). Here we have looked for a correlation in DAT distribution with sites rich in nAChRS.
Wang Hong +3 more
openaire +1 more source
Temperature Dependence And Activation Energy of nAChR Gating [PDF]
Biophysical Journal, 2009 Neuromuscular acetylcholine receptors (AChRs) are ion channels that alternately adopt conformations that either allow or prohibit the flow of ions across the membrane. These two stable end states are separated by an energy barrier, the peak of which is called the transition region.
Shaweta Gupta, Anthony Auerbach
openaire +2 more sources
Evidence for a role for α6∗ nAChRs in l-dopa-induced dyskinesias using parkinsonian α6∗ nAChR gain-of-function mice [PDF]
Neuroscience, 2015 l-Dopa-induced dyskinesias (LIDs) are a serious side effect of dopamine replacement therapy for Parkinson's disease. The mechanisms that underlie LIDs are currently unclear. However, preclinical studies indicate that nicotinic acetylcholine receptors (nAChRs) play a role, suggesting that drugs targeting these receptors may be of therapeutic benefit. To
Maryka Quik +4 more
openaire +3 more sources
Astron.Nachr.326:867-869,2005, 2005 Report on the Nordita Workdays on Quasi-Peridic Oscillations (QPOs).
arxiv +1 more source
Berichtigung zu Astr. Nachr. No. 2133 [PDF]
Astronomische Nachrichten, 1877 n ...
openaire +3 more sources
Defect via differential forms with logarithmic poles [PDF]
Math. Nachr. 284 (2011), no. 17-18, 2148-2158, 2009 We prove formulae for the Hodge numbers of big resolutions of singular hypersurfaces satisfying a Bott-type vanishing condition.
arxiv +1 more source
Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-Selective Positive Allosteric Modulator [PDF]
Molecular Pharmacology, 2016 Positive allosteric modulators (PAMs) of nicotinic acetylcholine (ACh) receptors (nAChRs) have potential clinical applications in the treatment of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity, and 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrrazol-4-yl)isoxazole (CMPI) has been
Farah Deba +3 more
openaire +3 more sources
Solar and stellar dynamos -- latest developments [PDF]
Astron.Nachr. 323 (2002) 411-416, 2002 Recent progress in the theory of solar and stellar dynamos is reviewed. Particular emphasis is placed on the mean-field theory which tries to describe the collective behavior of the magnetic field. In order to understand solar and stellar activity, a quantitatively reliable theory is necessary.
arxiv +1 more source