Results 11 to 20 of about 76,340 (268)

α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer [PDF]

Drug Delivery, 2018
A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed.
Dong Mei, Libo Zhao, Binlong Chen, Xiaoyan Zhang, Xiaoling Wang, Zhiying Yu, Xin Ni, Qiang Zhang   +7 more
openalex   +2 more sources

Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells. [PDF]

PLoS ONE, 2016
Gastric cancer incidence demonstrates a strong etiologic association with smoking. Nicotine, the major component in tobacco, is a survival agonist that inhibits apoptosis induced by certain chemotherapeutic agents, but the precise mechanisms involved ...
Yanfei Jia, Haiji Sun, Hongqiao Wu, Huilin Zhang, Xiuping Zhang, Dongjie Xiao, Xiaoli Ma, Yunshan Wang   +7 more
doaj   +2 more sources

The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression

Cancers, 2015
Pancreatic cancer shows a strong correlation with smoking and the current therapeutic strategies have been relatively ineffective in improving the survival of patients.
Courtney Schaal, Jaya Padmanabhan, Srikumar Chellappan   +2 more
openalex   +2 more sources

Apolipoprotein (a)/Lipoprotein(a)-Induced Oxidative-Inflammatory α7-nAChR/p38 MAPK/IL-6/RhoA-GTP Signaling Axis and M1 Macrophage Polarization Modulate Inflammation-Associated Development of Coronary Artery Spasm

Oxidative Medicine and Cellular Longevity, 2022
Objective. Apolipoprotein (a)/lipoprotein(a) (Lp(a)), a major carrier of oxidized phospholipids, and α7‐nicotinic acetylcholine receptor (α7‐nAChR) may play an important role in the development of coronary artery spasm (CAS).
Yen-Kuang Lin, C. Yeh, Kuang-Tai Kuo, Iat-Hang Fong, Vijesh Kumar Yadav, N. Kounis, P. Hu, Ming-Yow Hung   +7 more
semanticscholar   +1 more source

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer

Frontiers in Cell and Developmental Biology, 2021
Secreted Ly6/uPAR-related protein 1 (SLURP-1) is a secreted Ly6/uPAR protein that negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR), participating in control of cancer cell growth.
M. Bychkov, M. Shulepko, O. Shlepova, D. Kulbatskii, I. A. Chulina, A. Paramonov, L. K. Baidakova, V. N. Azev, S. Koshelev, M. Kirpichnikov, Z. Shenkarev, E. Lyukmanova   +11 more
semanticscholar   +1 more source

The effects of sodium benzoate exposure on learning and neurobehavior during the prepubertal period in rats

Türk Biyokimya Dergisi, 2022
Exposure to food additives, especially during the critical development period, has been associated with some behavioral disorders and learning difficulties in childhood.
İlhan İlter, Kumbul Doğuç Duygu, Büyükbayram Halil İbrahim, Aşcı Çelik Dilek, Gurbuz Nilgun, Gultekin Fatih   +5 more
doaj   +1 more source

In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [¹²⁵I]Iodo-ASEM and [¹⁸F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic Acetylcholine Receptors

Molecules, 2020
The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in several cognitive and physiologic processes; its expression levels and patterns change in neurologic and psychiatric diseases, such as schizophrenia and Alzheimer’s disease,
Cornelius K. Donat, Henrik H. Hansen, Hanne D. Hansen, Ronnie C. Mease, Andrew G. Horti, Martin G. Pomper, Elina T. L’Estrade, Matthias M. Herth, Dan Peters, Gitte M. Knudsen, Jens D. Mikkelsen   +10 more
doaj   +1 more source

The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site

Toxins, 2021
α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR.
Alican Gulsevin, Roger L. Papke, Clare Stokes, Hue N. T. Tran, Aihua H. Jin, Irina Vetter, Jens Meiler   +6 more
doaj   +1 more source

Molecular mechanisms of α7-nAchR-mediated anti-inflammatory effects

, 2021
The cholinergic anti-inflammatory pathway is described as an interaction between the nervous system and the immune system. This interaction is regulated by the α7 subtype of cholinergic nicotinic Ach receptors (α7-nAchR), which leads to a marked decrease
M. E. Youssef, Y. Moustafa, Heba M. Abdelrazek   +2 more
semanticscholar   +1 more source

Cloning of Two Nicotinic Acetylcholine Receptor Genes from Bemisia tabaci (Gennadius)

Turkish Journal of Agriculture: Food Science and Technology, 2020
Nicotinic acetylcholine receptors (nAChRs) mediate fast cholinergic synaptic transmission in the insect nervous system. Neonicotinoid insecticides exhibit insecticidal activities by targeting these receptors.
Gül Satar, Mehmet Rifat Ulusoy, Ke Dong
doaj   +1 more source