Cholesterol modulates acetylcholine receptor diffusion by tuning confinement sojourns and nanocluster stability [PDF]
, 2018 Translational motion of neurotransmitter receptors is key for determining receptor number at the synapse and hence, synaptic efficacy. We combine live-cell STORM superresolution microscopy of nicotinic acetylcholine receptor (nAChR) with single-particle ...
Barrantes, Francisco Jose +2 more
core +2 more sources
Molecules, 2023 Nicotinic acetylcholine receptors (nAChRs) are involved in various central nervous system functions and have also been implicated in several neurodegenerative disorders.
Karanveer Singh +5 more
doaj +1 more source
An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression [PDF]
, 1996 A new tRNA, THG73, has been designed and evaluated as a vehicle for incorporating unnatural amino acids site-specifically into proteins expressed in vivo using the stop codon suppression technique.
Abelson, John N. +7 more
core +1 more source
Cellular Physiology and Biochemistry, 2014 Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling with airway smooth muscle (ASM) hypertrophy and hyperplasia.
Yongliang Jiang +7 more
doaj +1 more source
Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells [PDF]
, 2018 Phosphocholine-modified bacterial cell wall components are virulence factors enabling immune evasion and permanent colonization of the mammalian host, by mechanisms that are poorly understood.
Grau, Veronika +11 more
core +1 more source
Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier
Frontiers in Immunology, 2021 Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) is critical for the pathogenesis of Escherichia coli (E. coli) K1 meningitis, a severe central nervous system infection of the neonates. However, little is known about how E.
Xiaolong He +19 more
doaj +1 more source
Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]
, 2017 We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range,
Einav, Tal, Phillips, Rob
core +4 more sources
SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells [PDF]
, 2009 Cochlear hair cells use SK2 currents to shape responses to cholinergic efferent feedback from the brain. Using SK2-/- mice, we demonstrate that, in addition to their previously defined role in modulating hair cell membrane potentials, SK2 channels are ...
Adelman, John P. +8 more
core +1 more source
Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine [PDF]
, 2013 Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA).
A Taly +78 more
core +6 more sources
Journal of Clinical Medicine, 2019 Background: Hepatocellular carcinoma (HCC) is a worldwide health problem. Currently, there is no effective clinical therapeutic strategy for HCC. Smoking is associated with several malignant diseases including cancers. Experimental approach: However, the
Ching Li +5 more
semanticscholar +1 more source