Results 61 to 70 of about 76,340 (268)

Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]

, 2009
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan, Chebib, Mary, Elgoyhen, Ana Belen, McIntosh, J. Michael, Vincler, Michelle   +4 more
core   +1 more source

Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor. [PDF]

PLoS ONE, 2013
BackgroundThe cholinergic anti-inflammatory pathway is an endogenous mechanism by which the autonomic nervous system attenuates macrophage activation via nicotinic acetylcholine receptors (nAChR).
Andrea Nemethova, Klaus Michel, Pedro J Gomez-Pinilla, Guy E Boeckxstaens, Michael Schemann   +4 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Impaired Expression of Neuregulin 1 and Nicotinic Acetylcholine Receptor β4 Subunit in Diverticular Disease

Frontiers in Cellular Neuroscience, 2019
Neuregulin 1 (NRG1) regulates the expression of the nicotinic acetylcholine receptor (nAChR) and is suggested to promote the survival and maintenance of the enteric nervous system (ENS), since deficiency of its corresponding receptor complex ErbB2/ErbB3 ...
Martina Barrenschee, François Cossais, Martina Böttner, Jan-Hendrik Egberts, Thomas Becker, Thilo Wedel   +5 more
doaj   +1 more source

Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor. [PDF]

PLoS ONE, 2008
BACKGROUND: Cigarette smoking adversely affects endochondral ossification during the course of skeletal growth. Among a plethora of cigarette chemicals, nicotine is one of the primary candidate compounds responsible for the cause of smoking-induced ...
Atsuo Kawakita, Kazuki Sato, Hatsune Makino, Hiroyasu Ikegami, Shinichiro Takayama, Yoshiaki Toyama, Akihiro Umezawa   +6 more
doaj   +1 more source

The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes

Protein & Cell, 2017
The α3* nAChRs, which are considered to be promising drug targets for problems such as pain, addiction, cardiovascular function, cognitive disorders etc., are found throughout the central and peripheral nervous system.
Manyu Xu, Xiaopeng Zhu, Jinfang Yu, Jinpeng Yu, S. Luo, Xinquan Wang   +5 more
semanticscholar   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, EarlyView.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor [PDF]

, 2008
Understanding the gating mechanism of the nicotinic acetylcholine receptor (nAChR) and similar channels constitutes a significant challenge in chemical neurobiology.
Dougherty, Dennis A., Hanek, Ariele P., Lester, Henry A.   +2 more
core  

Single-cell quantitative expression of nicotinic acetylcholine receptor mRNA in rat hippocampal interneurons.

PLoS ONE
Hippocampal interneurons are a very diverse population of cells. Using single-cell quantitative PCR to analyze rat CA1 hippocampal interneurons, we quantified neuronal nicotinic acetylcholine receptor (nAChR) mRNA subunit expression and detailed possible
Doris C Jackson, Richard M Burgon, Spencer Thompson, Sterling N Sudweeks   +3 more
doaj   +1 more source

Influence of Tobacco Smoke Exposure on the Protein Expression of α7 and α4 Nicotinic Acetylcholine Receptors in Squamous Cell Carcinoma Tumors of the Upper Aerodigestive Tract (Out of the Larynx)

Substance Abuse: Research and Treatment, 2018
Purpose: To assess protein expression of α7 and α4 nicotinic acetylcholine receptors (nAChR) subtypes in squamous cell carcinoma of the upper aerodigestive track (out of the larynx) according to tobacco smoke exposure, considering the general ...
Bertha B Montaño-Velázquez, Juan C Benavides Méndez, Francisco J García-Vázquez, Ernesto Conde-Vázquez, Magdalena Sánchez-Uribe, Cecilia R Taboada-Murrieta, Kathrine Jáuregui-Renaud   +6 more
doaj   +1 more source