Results 71 to 80 of about 76,340 (268)

Alpha5 Nicotinic Acetylcholine Receptor Contributes to Nicotine-Induced Lung Cancer Development and Progression

Frontiers in Pharmacology, 2017
Nicotine and nicotinic acetylcholine receptors (nAChRs) are considered to be involved in lung cancer risk, onset and progression, but their precise physiological roles in these contexts remain unclear.
Hai-Ji Sun, Yan-Fei Jia, Xiao-Li Ma
doaj   +1 more source

Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR

Cellular Physiology and Biochemistry, 2017
Background/Aims: The proliferation of human bronchial smooth muscle cells (HBSMCs) is a key pathophysiological component of airway remodeling in chronic obstructive pulmonary disease (COPD) for which pharmacotherapy is limited, and only slight ...
W. Hong, G. Peng, B. Hao, B. Liao, Zhuxiang Zhao, Yumin Zhou, F. Peng, X. Ye, Lingmei Huang, Mengning Zheng, J. Pu, Chunxiao Liang, Erkang Yi, Huanhuan Peng, Bing Li, P. Ran   +15 more
semanticscholar   +1 more source

Placental‐Derived Connective Tissue Matrix Mediates Murine Recurrent Laryngeal Nerve Regeneration

The Laryngoscope, EarlyView.
Placentally derived connective tissue matrix (pd‐CTM) innately contains various neurotrophic, angiogenic, anti‐inflammatory, and tissue remodeling cytokines. In this mouse model of unilateral vocal fold paralysis, we investigate its effects on recurrent laryngeal nerve (RLN) regeneration and reinnervation of the right thyroarytenoid (TA) muscle after ...
Sunjay Anekal, Ananya Tadikonda, Gabriel Sobczak, Lena W. Chen, Aditya Bhatt, Troy Wesson, Patrick R. Finnegan, Stacey Halum   +7 more
wiley   +1 more source

On some normability conditions [PDF]

, 2005
Various normability conditions of locally convex spaces (including Vogt interpolation classes DN and as well as quasi- and asymptotic normability) are investigated.
Aytuna, Aytuna, Bierstedt, Bierstedt, Bonet, Bonet, Bonet, Bonet, Dubinsky, Goncharov, Grothendieck, Grothendieck, Jarchow, Kocatepe, Köthe, Köthe, Meise, Meise, Mityagin, Mityagin, Mityagin, Terzioğlu, Terzioğlu, Tidten, Valdivia, Vogt, Vogt, Vogt, Vogt, Zahariuta, Zahariuta, Zahariuta, Zahariuta, Zahariuta, Önal, Önal   +35 more
core   +1 more source

The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials

Acta Pharmaceutica Sinica B, 2017
The alpha-7 nicotinic acetylcholine receptor (α7 nAChR), consisting of homomeric α7 subunits, is a ligand-gated Ca2+-permeable ion channel implicated in cognition and neuropsychiatric disorders.
Taoyi Yang, Ting Xiao, Qi Sun, Kewei Wang   +3 more
doaj   +1 more source

Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling

Cell Communication and Signaling, 2022
Background Immunotherapy has proven to be an emerging treatment for non-small-cell lung cancer in recent years. Notably, smokers show higher programmed cell death ligand-1 (PD-L1) expression and better responses to PD-1/PD-L1 inhibitors than nonsmokers ...
Ping Zhu, Zhengxin Jin, Guiyu Kang, Yanfei Jia, Duanrui Liu, Qian Zhang, Feiyang Guo, Ying Jia, Yang Jiao, Jingtan Li, Haiji Sun, Xiaoli Ma   +11 more
doaj   +1 more source

The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice

Biomedicines, 2023
Nicotine, an abundant molecule in tobacco, has immunomodulatory effects on inflammatory diseases, primarily due to the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR).
Young-Eun Kim, Jae-Hyun Lee, Eun-Ju Lee, Do Hoon Kim, Mi Ryeong Jeong, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Jeehee Youn, Eun-Ju Chang, Yong-Gil Kim   +10 more
doaj   +1 more source

Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward

Journal of Neuroscience, 2016
Upregulation of β2 subunit-containing (β2*) nicotinic acetylcholine receptors (nAChRs) is implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to upregulate β2* nAChRs more than nonmenthol cigarette smokers.
Brandon J. Henderson, Teagan R Wall, Beverley M Henley, Charlene H. Kim, Weston A. Nichols, R. Moaddel, C. Xiao, H. Lester   +7 more
semanticscholar   +1 more source

Approximation of Dirac operators with δ‐shell potentials in the norm resolvent sense, II: Quantitative results

Mathematische Nachrichten, EarlyView.
Abstract This paper is devoted to the approximation of two‐ and three‐dimensional Dirac operators HV∼δΣ$H_{\widetilde{V} \delta _\Sigma }$ with combinations of electrostatic and Lorentz scalar δ$\delta$‐shell interactions in the norm resolvent sense. Relying on results from Behrndt, Holzmann, and Stelzer‐Landauer [Math. Nachr.
Jussi Behrndt, Markus Holzmann, Christian Stelzer‐Landauer   +2 more
wiley   +1 more source

Characterisation of nicotine receptors on human peripheral blood mononuclear cells (PBMC) [PDF]

, 2009
“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s00011-008-8171-xAim and objective: The aim of the work was to characterise the nAChRs on human PBMC.
Parsons, M., Whelan, C.J., Wongsriraksa, A.   +2 more
core   +1 more source