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Ratiometric NAD+ Sensors Reveal Subcellular NAD+ Modulators

ACS Sensors, 2022
AbstractMapping NAD+ dynamics in live cells and human are essential for translating NAD+ interventions into effective therapies. Yet genetically encoded NAD+ sensors with better specificity and pH-resistance are still needed for cost-effective monitoring of subcellular and clinical NAD+.
Liuqing Chen   +6 more
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The NAD Interactome, Identification of Putative New NAD-Binding Proteins

2022
Nicotinamide adenine dinucleotide (NAD) is an essential metabolite in normal cellular physiology and its deregulation may lead to several pathological conditions. NAD interacts with a vast number of proteins, acting as a coenzyme, as a substrate and regulating the interaction between proteins.
Sara Duarte-Pereira   +3 more
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NAD+-pyridoxine and NAD+-pyridoxamine complexes

Biochimica et Biophysica Acta (BBA) - General Subjects, 1971
Abstract 1. 1. NAD+-pyridoxamine complexes were studied by fluorescence techniques at 30° over a pH range of 8.4–10.0. 2. 2. The polarization factor was seen to increase with increasing NAD+ concentration in all cases. 3. 3. Fluorescence quenching studis established large complex formation constants for both complexes. 4. 4.
V.D. Anand, W.R. Carper
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Nad(P)+-nad(p)h models. 57

Tetrahedron, 1986
Abstract NAD(P)H/NAD(P) + and related compounds have intrinsic chirality against the axis alone the C 3 –C carbonyl single bond. A model compound which has a stable conformation with respect to this chirality was synthesized and the conformational relationship between the carbonyl dipole and the reacting hydrogen was studied.
Atsuyoshi Ohno   +4 more
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Adriamycin-catalyzed aerobic photooxidation of NAD dimers to NAD+

Biochimica et Biophysica Acta (BBA) - General Subjects, 1989
The photooxidation of the dimers of nicotinamide adenine dinucleotide, (NAD)2, is catalyzed by adriamycin under aerobic conditions. (NAD)2 and O2 react in 1:1 molar ratio to yield 2 mol of NAD+. Experiments carried out by irradiating at 340 and 485 nm, corresponding to the absorption maxima of (NAD)2 and adriamycin, respectively, clearly indicate that ...
V, Carelli   +5 more
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