Results 21 to 30 of about 686 (83)

In Silico Approach to Identify the Relationships between COVID-19 and Coronary Artery Disease/Rheumatoid Arthritis [PDF]

, 2023
Global public has been threatened by the coronavirus disease 2019 (COVID-19) pandemic which led to nearly 15 million deaths around the world. People with complex and chronic diseases usually have more severe COVID-19 symptoms than the general population.
Akçay, Sevinç, Pirim, Dilek
core   +1 more source

In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes

Chemistry – A European Journal, Volume 31, Issue 29, May 22, 2025.
The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer, Alexander Sherwood, Thomas Kirkland, Thomas Krüger, Jakob Worbs, Olaf Kniemeyer, Markus Gressler, Dirk Hoffmeister   +7 more
wiley   +1 more source

Reconstitution of Methionine Cycle With ATP Regeneration for Whole‐Cell Catalysis of Creatine Production in Engineered Escherichia coli

Microbial Biotechnology, Volume 18, Issue 5, May 2025.
In this study, we constructed a CR biosynthesis pathway in E. coli by introducing exogenous AGAT and GAMT. We integrated the reconstitution methionine cycle with a polyphosphate kinase‐based ATP regeneration system, achieving a CR titre of 5.27 g/L with a productivity of 0.22 g/L/h.
Yuhua Sheng, Yaokang Wu, Linpei Zhang, Xueqin Lv, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu   +8 more
wiley   +1 more source

Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]

, 2015
Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core  

Engineering Caffeic Acid O‐Methyltransferase for Efficient De Novo Ferulic Acid Synthesis

Engineering in Life Sciences, Volume 25, Issue 4, April 2025.
ABSTRACT Ferulic acid is a high‐value chemical synthesized in plants. The ferulic acid biosynthesis is still affected by the insufficient methylation activity of caffeic acid O‐methyltransferase (COMT). In this study, we engineered COMT from Arabidopsis thaliana to match caffeic acid, and the mutant COMTN129V‐H313A‐F174L showed 4.19‐fold enhanced ...
Huai Qi Shang, Qing Bo Yang, Shan Qiang, Rong Zheng, Chao Qun Zhang, Ching Yuan Hu, Qi Hang Chen, Yong Hong Meng   +7 more
wiley   +1 more source

Gene mining a marama bean expressed sequence tags (ESTs) database: Embryonic seed development genes and microsatellite marker identification [PDF]

, 2015
Tylosema esculentum (marama bean) is one of the underutilized legumes that have potential to provide protein and fatty acids to ensure food security in dry parts of Southern Africa.
Chimwamurombe, PM, Sheehama, EN
core   +2 more sources

The V‐Shaped Structuring Regulated via the LuxS‐Dependent Quorum‐Sensing Pathway Is Associated With Lactiplantibacillus plantarum Survivability in Acidic Environments

Food Frontiers, Volume 6, Issue 2, Page 801-818, March 2025.
This study elucidates how the V‐shaped multicellular structuring facilitates the 3D‐biofilm formation through the LuxS‐dependent quorum‐sensing pathway, which provides an extraordinary protection mode for cellular survivability in highly acidic conditions.
Athira Venugopal, Ronit Vogt Sionov, Yulia Kroupitski, Doron Steinberg, Moshe Shemesh   +4 more
wiley   +1 more source

Bioalkylation Strategies to Synthesize Allylated Tetrahydroisoquinolines by Using Norcoclaurine Synthase and O‐Methyltransferases

ChemCatChem, Volume 17, Issue 4, February 17, 2025.
The cascade using methionine adenosyltransferases (MATs), O‐methyltransferases (O‐MTs), and thioadenosine nucleosidase (MTAN) was utilized for the regioselective biocatalytic O‐allylation of a variety of catechols and tetrahydroisoquinolines. (S)‐Tetrahydroisoquinoline substrates were stereoselectively generated from the catecholamine dopamine and ...
Matthew T. Salinger, John M. Ward, Thomas S. Moody, Jack W. E. Jeffries, Helen C. Hailes   +4 more
wiley   +1 more source

Structure of \u3cem\u3eArabidopsis thaliana\u3c/em\u3e 5-Methylthioribose Kinase Reveals a More Occluded Active Site Than its Bacterial Homolog [PDF]

, 2007
Background: Metabolic variations exist between the methionine salvage pathway of humans and a number of plants and microbial pathogens. 5-Methylthioribose (MTR) kinase is a key enzyme required for methionine salvage in plants and many bacteria.
Cornell, Kenneth A., Howell, P. Lynne, Yang-Ku, Shao   +2 more
core   +7 more sources

α‐N‐Methyltransferase regiospecificity is mediated by proximal, redundant enzyme–substrate interactions

Protein Science, Volume 34, Issue 2, February 2025.
Abstract N‐Methylation of the peptide backbone confers pharmacologically beneficial characteristics to peptides that include greater membrane permeability and resistance to proteolytic degradation. The borosin family of ribosomally synthesized and post‐translationally modified peptides offer a post‐translational route to install amide backbone α‐N ...
Kathryn K. Crone, Jason W. Labonte, Mikael H. Elias, Michael F. Freeman   +3 more
wiley   +1 more source