Results 11 to 20 of about 968,543 (216)
Aging Cell, Volume 21, Issue 7, July 2022., 2022 Nicotinamide riboside (NR) and caffeine increase nicotinamide adenine dinucleotide (NAD), transiently modulate bioenergetic functions, and change the expression of NAD‐synthesizing, recycling, or degrading genes in dermal fibroblasts or induced pluripotent stem cell (iPSC)‐derived neural progenitors and astrocytes from late‐onset Alzheimer's disease ...
Woo‐In Ryu +6 more
wiley +1 more source
CD38 Drives Progress of Osteoarthritis by Affecting Cartilage Homeostasis
Orthopaedic Surgery, Volume 14, Issue 5, Page 946-954, May 2022., 2022 CD38 is a membrane‐bound protein. This study primarily implicates CD38 as an important regulator of chondrogenic differentiation. Inhibition of CD38 demonstrated protection against cartilage degeneration, which suggests that CD38 could be a potential therapeutic target for OA.
Jin‐jin Ma +9 more
wiley +1 more source
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging
Aging Cell, Volume 21, Issue 4, April 2022., 2022 The NADase CD38 plays a key role in age‐related NAD decline. The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice. The increase in median and maximal lifespan was about 10%. Abstract Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction.
Thais R. Peclat +11 more
wiley +1 more source
Acta Crystallographica Section F, Volume 78, Issue 2, Page 52-58, February 2022., 2022 The crystal structure of a short‐chain dehydrogenase/reductase from Burkholderia phymatum offers insights into its possible functions and likely inhibitors of its enzymatic functions.Burkholderia phymatum is an important symbiotic nitrogen‐fixing betaproteobacterium. B.
Jawaher Alenazi +4 more
wiley +1 more source
The FEBS Journal, Volume 289, Issue 4, Page 955-964, February 2022., 2022 Increased IDO activity towards de novo nicotinamide synthesis is a hallmark of alternatively activated macrophages. IDO upregulation in alternatively activated macrophages may be an attempt to compensate for insufficient NAD availability. Manipulation of nicotinamide metabolism may shift macrophage metabolism, thereby providing a therapeutic approach ...
Melinda S. Suchard, Dana M. Savulescu
wiley +1 more source
Acta Crystallographica Section D, Volume 77, Issue 10, Page 1317-1335, October 2021., 2021 The homospermidine synthases from P. aeruginosa and B. viridis, as well as their single‐residue variants, are compared based on crystal structures and activity assays. A high structural similarity is demonstrated, suggesting the equivalent involvement of relevant residues in the reaction mechanism and catalytic dependence on cation–π interaction ...
F. Helfrich, Axel J. Scheidig
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 25, Issue 13, Page 5884-5898, July 2021., 2021 Abstract Nicotinamide adenine dinucleotide (NAD+) is crucial for cell energy metabolism and many signalling processes. Recently, we proved the role of ecto‐enzymes in controlling adenine nucleotide–dependent pathways during calcific aortic valve disease (CAVD).
Patrycja Jablonska +9 more
wiley +1 more source
It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core +2 more sources
The evaluation of possibilities of sustainable tourism and recreation in the Mrtva Tisa area near Čurug7 [PDF]
Glasnik Srpskog Geografskog Društva, 2008 The preserved parts of the nature or areas that are inteded to be protected and well-planned in terms of harmonizing the nature and tourist activities and recreation could become potential eco-tourist attractions.
Nađ Imre
doaj +1 more source
Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
Life, 2021 Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients.
Petr Kelbich +10 more
doaj +1 more source