Results 41 to 50 of about 989,508 (337)

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Cells, 2019
Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-
Haruhiro Higashida, Minako Hashii, Yukie Tanaka, Shigeru Matsukawa, Yoshihiro Higuchi, Ryosuke Gabata, Makoto Tsubomoto, Noriko Seishima, Mitsuyo Teramachi, Taiki Kamijima, Tsuyoshi Hattori, Osamu Hori, Chiharu Tsuji, Stanislav M. Cherepanov, Anna A. Shabalova, Maria Gerasimenko, Kana Minami, Shigeru Yokoyama, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Alla B. Salmina, Olga Lopatina   +22 more
doaj   +1 more source

NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction

Circulation Research, 2021
Supplemental Digital Content is available in the text. Rationale: Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without effective therapies.
Dan Tong, G. Schiattarella, Nan Jiang, Francisco Altamirano, P. Szweda, Abdallah Elnwasany, Dong I. Lee, Heesoo Yoo, D. Kass, L. Szweda, S. Lavandero, E. Verdin, T. Gillette, Joseph A. Hill   +13 more
semanticscholar   +1 more source

Crystal Structure of Thermotoga maritima α-Glucosidase AglA Defines a New Clan of NAD+-dependent Glycosidases [PDF]

, 2003
Glycoside hydrolase family 4 represents an unusual group of glucosidases with a requirement for NAD(+), divalent metal cations, and reducing conditions. The family is also unique in its inclusion of both alpha- and beta-specific enzymes.
Hoffmann, Volker, Liebl, Wolfgang, Lodge, Jacinta A., Maier, Timm, Sträter, Norbert   +4 more
core   +1 more source

Targeted and untargeted metabolomics provide insight into the consequences of glycine‐N‐methyltransferase deficiency including the novel finding of defective immune function

Physiological Reports, Volume 8, Issue 18, September 2020., 2020
Abstract Fatty liver disease is increasing along with the prevalence of obesity and type‐2 diabetes. Hepatic fibrosis is a major health complication for which there are no efficacious treatment options available. A better understanding of the fundamental mechanisms that contribute to the accumulation of fibrosis is needed.
Brandon J. Eudy, Caitlin E. McDermott, Xiuli Liu, Robin P. da Silva   +3 more
wiley   +1 more source

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Nature Communications, 2018
Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan.
C. Martens, Blair A. Denman, Melissa R Mazzo, M. Armstrong, N. Reisdorph, M. McQueen, M. Chonchol, D. Seals   +7 more
semanticscholar   +1 more source

NAD+ Metabolism in Cardiac Health, Aging, and Disease.

Circulation, 2021
Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and redox homeostasis as well as in DNA repair and protein deacetylation reactions.
M. Abdellatif, S. Sedej, G. Kroemer
semanticscholar   +1 more source

A novel deamido-NAD+-binding site revealed by the trapped NAD-adenylate intermediate in the NAD+ synthetase structure [PDF]

Structure, 1998
Nicotinamide adenine dinucleotide (NAD+) has a central role in life processes. The ubiquitous enzyme NAD+ synthetase catalyzes a key step in NAD+ biosynthesis, transforming deamido-NAD+ into NAD+ by a two-step reaction. NAD+ synthetase belongs to the amidotransferase family and has been recognized as a member of the family of N-type ATP ...
RIZZI, Menico, BOLOGNESI M., CODA A.
openaire   +3 more sources

Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time [PDF]

, 2003
DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways.
Asakura, Shoji, Caldecott, Keith W, de Murcia, Gilbert, Hester, Susan D, Nakamura, Jun, Swenberg, James A   +5 more
core   +3 more sources

Structural characterization of borneol dehydrogenase from Pseudomonas sp. TCU‐HL1

Acta Crystallographica Section F, Volume 76, Issue 7, Page 309-313, July 2020., 2020
The structure of a Pseudomonas borneol dehydrogenase was determined at 1.84 Å resolution. Major differences from its homologues in the C‐terminal helices and the associated loops may suggest determinants for substrate recognition.During the microbial degradation of borneol, a bicyclic plant monoterpene, it is first converted into camphor by borneol ...
Aye Aye Khine, Hao-Ping Chen, Kai-Fa Huang, Tzu-Ping Ko   +3 more
wiley   +1 more source

Outlook of logging perspectives in the Czech Republic for the period 2013-2032

Journal of Forest Science, 2014
The aim of the submitted work was to analyze the outlook of logging perspectives in the next two decades (2013-2032) for all forests in the territory of the Czech Republic.
M. Synek, J. Vašíček, M. Zeman
doaj   +1 more source