Results 61 to 70 of about 213,525 (212)

Dual treatment with kynurenine pathway inhibitors and NAD+ precursors synergistically extends life span in Drosophila

Aging Cell, Volume 23, Issue 4, April 2024.
Our study explores the impact of kynurenine pathway (KP) modulation and NAD+ supplementation on aging Drosophila. We found that KP inhibition combined with NAD+ precursors significantly enhances physical performance and extends life span. These findings suggest that targeted interventions in KP and NAD+ metabolism can synergistically improve health ...
Mariann M. Gabrawy, Reyhan Westbrook, Austin King, Nick Khosravian, Neeraj Ochaney, Tagide DeCarvalho, Qinchuan Wang, Yuqiong Yu, Qiao Huang, Adam Said, Michael Abadir, Cissy Zhang, Pratik Khare, Jennifer E. Fairman, Anne Le, Ginger L. Milne, Fernando J. Vonhoff, Jeremy D. Walston, Peter M. Abadir   +18 more
wiley   +1 more source

Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?

Brain Sciences, 2020
Brain ischemia after central nervous system (CNS) bleeding significantly influences the final outcome of patients. Catalytic activities of aspartate aminotransferase (AST) in the cerebrospinal fluid (CSF) to detect brain ischemia were determined in this ...
Petr Kelbich, Tomáš Radovnický, Iva Selke-Krulichová, Jan Lodin, Inka Matuchová, Martin Sameš, Jan Procházka, Jan Krejsek, Eva Hanuljaková, Aleš Hejčl   +9 more
doaj   +1 more source

Metabolic control of mitophagy

European Journal of Clinical Investigation, Volume 54, Issue 4, April 2024.
Abstract Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival.
Andreas Zimmermann, Frank Madeo, Abhinav Diwan, Junichi Sadoshima, Simon Sedej, Guido Kroemer, Mahmoud Abdellatif   +6 more
wiley   +1 more source

Dynamical analysis of machining tool body with reinforced inner core of circular shape [PDF]

Applied and Computational Mechanics, 2009
The vibration analysis of a clamped beam structure representing vibrating machining body tool is solved in this paper. The required modal properties of beam are obtained by application the reinforcing core with circular cross section.
Naď M.
doaj  

Personalized Porous Gelatin Methacryloyl Sustained‐Release Nicotinamide Protects Against Noise‐Induced Hearing Loss

Advanced Science, Volume 11, Issue 12, March 27, 2024.
NAD+ decreases in cochlear after noise trauma, and nicotinamide supplementation boosts NAD+ and prevents neuroexcitatory in cochlear by round window administration. Personalized porous gelatin methacryloyl (PGMA) achieves long term drug release in cochlear, and nicotinamide encapsulated PGMA enhances mitochondria and synapse function, and protects ...
Baoyi Feng, Tingting Dong, Xinyu Song, Xiaofei Zheng, Chenxi Jin, Zhenzhe Cheng, Yiqing Liu, Wenjie Zhang, Xueling Wang, Yong Tao, Hao Wu   +10 more
wiley   +1 more source

Creativity from Robert Sternberg's perspective [PDF]

Zbornik Radova Filozofskog Fakulteta u Prištini
This paper aims to present and analyze both theories and models of Robert Sternberg, one of the most prolific and well-cited researchers in the field of creativity.
Nađ Ivona J.
doaj   +1 more source

Biodistribution and toxicity assessment of methoxyphenyl phosphonium carbosilane dendrimers in 2D and 3D cell cultures of human cancer cells and zebrafish embryos

Scientific Reports, 2023
The consideration of human and environmental exposure to dendrimers, including cytotoxicity, acute toxicity, and cell and tissue accumulation, is essential due to their significant potential for various biomedical applications.
Zuzana Žmudová, Zuzana Šanderová, Michaela Liegertová, Stanislav Vinopal, Regina Herma, Luděk Sušický, Monika Müllerová, Tomáš Strašák, Jan Malý   +8 more
doaj   +1 more source

Postoj studentů sociální pedagogiky k homoparentálním rodinám [PDF]

Sociální Pedagogika
The paper is focused on the research of the attitude of the students of the Bachelor's and Master's degree programmes in social pedagogy from the J. E.
Pavel Doulík, Jiří Škoda, Barbora Čechová, Zuzana Procházková   +3 more
doaj   +1 more source

Aerial Bombing Crater Identification: Exploitation of Precise Digital Terrain Models

ISPRS International Journal of Geo-Information, 2020
Places of past conflicts and persistent objects that reflect such events often attract the attention of archaeological prospection which facilitates the construction of conflict narratives. Field prospection as a precise method for localization of aerial
Martin Dolejš, Jan Pacina, Martin Veselý, Dominik Brétt   +3 more
doaj   +1 more source

Bioprospecting of a Novel Plant Growth-Promoting Bacterium Bacillus altitudinis KP-14 for Enhancing Miscanthus × giganteus Growth in Metals Contaminated Soil

Biology, 2020
Use of plant growth-promoting bacteria (PGPB) for cultivation of the biofuel crop Miscanthus × giganteus (Mxg) in post-military and post-mining sites is a promising approach for the bioremediation of soils contaminated by metals.
Kumar Pranaw, Valentina Pidlisnyuk, Josef Trögl, Hana Malinská   +3 more
doaj   +1 more source