Results 61 to 70 of about 968,543 (216)

Effect of Dietary Ketosis and Nicotinamide Riboside on Hippocampal Krebs Cycle Intermediates and Mitochondrial Energetics in a DNA Repair‐Deficient 3xTg/POLβ+/− Alzheimer Disease Mouse Model

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
Alzheimer disease causes neurodegeneration of the hippocampus. It impedes brain glucose metabolism and impairs mitochondrial energy along electron transport chain (ETC). Will a ketone‐based diet with nicotinamide riboside restore hippocampal energy in an Alzheimer mouse model?
Robert Pawlosky, Tyler G. Demarest, M. Todd King, Darlene Estrada, Richard L. Veech, Vilhelm A. Bohr   +5 more
wiley   +1 more source

Dual treatment with kynurenine pathway inhibitors and NAD+ precursors synergistically extends life span in Drosophila

Aging Cell, Volume 23, Issue 4, April 2024.
Our study explores the impact of kynurenine pathway (KP) modulation and NAD+ supplementation on aging Drosophila. We found that KP inhibition combined with NAD+ precursors significantly enhances physical performance and extends life span. These findings suggest that targeted interventions in KP and NAD+ metabolism can synergistically improve health ...
Mariann M. Gabrawy, Reyhan Westbrook, Austin King, Nick Khosravian, Neeraj Ochaney, Tagide DeCarvalho, Qinchuan Wang, Yuqiong Yu, Qiao Huang, Adam Said, Michael Abadir, Cissy Zhang, Pratik Khare, Jennifer E. Fairman, Anne Le, Ginger L. Milne, Fernando J. Vonhoff, Jeremy D. Walston, Peter M. Abadir   +18 more
wiley   +1 more source

Corporate Social Responsibility of Organizations as Part of a Quality Management System

Production Engineering Archives, 2021
The paper deals with the topic of social responsibility in selected organizations in the Czech Republic. This topic is mainly associated with the requirements for economical and ecological production.
Střihavková Elena, Svobodová Jaroslava, Vysloužilová Daniela   +2 more
doaj   +1 more source

LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner [PDF]

, 2023
Yi Chen, Yanwen Lu, Lei Yang, Wenliang Ma, Yuhan Dong, Shuoming Zhou, Ning Liu, Weidong Gan, Dongmei Li   +8 more
openalex   +1 more source

Сравнительный анализ технологических схем измельчения руд меди на польском предприятии KGHM POLSKA MIEDŹ S.A. [PDF]

, 2012
Приведено огляд технологічних схем подрібнення мідних руд на підприємтсві KGHM POLSKA MIEDŹ S.A. (Польща) та їх порівняльний аналіз.Приведен обзор технологических схем измельчения медных руд на предприятии KGHM POLSKA MIEDŹ S.A.
Nad, Alona, Надь, Алена
core  

Metabolic control of mitophagy

European Journal of Clinical Investigation, Volume 54, Issue 4, April 2024.
Abstract Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival.
Andreas Zimmermann, Frank Madeo, Abhinav Diwan, Junichi Sadoshima, Simon Sedej, Guido Kroemer, Mahmoud Abdellatif   +6 more
wiley   +1 more source

Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?

Brain Sciences, 2020
Brain ischemia after central nervous system (CNS) bleeding significantly influences the final outcome of patients. Catalytic activities of aspartate aminotransferase (AST) in the cerebrospinal fluid (CSF) to detect brain ischemia were determined in this ...
Petr Kelbich, Tomáš Radovnický, Iva Selke-Krulichová, Jan Lodin, Inka Matuchová, Martin Sameš, Jan Procházka, Jan Krejsek, Eva Hanuljaková, Aleš Hejčl   +9 more
doaj   +1 more source

NAD+-dependent DNA ligases of Mycobacterium tuberculosis and Streptomyces coelicolor [PDF]

, 2003
Sequencing of the genomes of Mycobacterium tuberculosis H37Rv and Streptomyces coelicolor A3(2) identified putative genes for an NAD+-dependent DNA ligase. We have cloned both open reading frames and overexpressed the protein products in Escherichia coli.
Bowater, Richard, Bullard, Desmond, Day, Jonathan, Kieser, Tobias, Sayer, Heather, Smith, Andrew, Wilkinson, Adam   +6 more
core   +1 more source

Personalized Porous Gelatin Methacryloyl Sustained‐Release Nicotinamide Protects Against Noise‐Induced Hearing Loss

Advanced Science, Volume 11, Issue 12, March 27, 2024.
NAD+ decreases in cochlear after noise trauma, and nicotinamide supplementation boosts NAD+ and prevents neuroexcitatory in cochlear by round window administration. Personalized porous gelatin methacryloyl (PGMA) achieves long term drug release in cochlear, and nicotinamide encapsulated PGMA enhances mitochondria and synapse function, and protects ...
Baoyi Feng, Tingting Dong, Xinyu Song, Xiaofei Zheng, Chenxi Jin, Zhenzhe Cheng, Yiqing Liu, Wenjie Zhang, Xueling Wang, Yong Tao, Hao Wu   +10 more
wiley   +1 more source

Dynamical analysis of machining tool body with reinforced inner core of circular shape [PDF]

Applied and Computational Mechanics, 2009
The vibration analysis of a clamped beam structure representing vibrating machining body tool is solved in this paper. The required modal properties of beam are obtained by application the reinforcing core with circular cross section.
Naď M.
doaj