Results 251 to 260 of about 741,550 (282)

NAD Kinase Is an AKT Substrate

Cancer Discovery, 2019
Abstract AKT-mediated phosphorylation of NAD kinase induces synthesis of NADP+ and NADPH.
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Developmental Ontogeny of NAD+ Kinase in the Rat Conceptus

Toxicology and Applied Pharmacology, 2001
The ubiquitous NAD+ kinase (NADK) is the only known enzyme to catalyze formation of NADP+ from NAD+. The capacity to maintain an adequate supply of NADP(H) has important implications for development because of its requirement as a cofactor and electron donor in biosynthesis and detoxication reactions.
S S, Akella, C, Harris
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Structural and Functional Characterization of Human NAD Kinase

Biochemical and Biophysical Research Communications, 2001
NADP is essential for biosynthetic pathways, energy, and signal transduction. Its synthesis is catalyzed by NAD kinase. Very little is known about the structure, function, and regulation of this enzyme from multicellular organisms. We identified a human NAD kinase cDNA and the corresponding gene using available database information.
F, Lerner, M, Niere, A, Ludwig, M, Ziegler   +3 more
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Crystallographic Studies of Mycobacterium tuberculosis Polyphosphate/ATP-NAD Kinase Complexed with NAD

Journal of Bioscience and Bioengineering, 2004
NAD kinase from Mycobacterium tuberculosis (Ppnk) uses ATP or inorganic polyphosphate [poly(P)]. Ppnk overexpressed in Escherichia coli was purified and crystallized in the presence of NAD. Preliminary X-ray analysis of the resultant crystal indicate that the crystal belongs to hexagonal space group P6(2)22 and is holo-Ppnk complexed with NAD.
Shigetarou, Mori, Masayuki, Yamasaki, Yukie, Maruyama, Keiko, Momma, Shigeyuki, Kawai, Wataru, Hashimoto, Bunzo, Mikami, Kousaku, Murata   +7 more
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Regulation of NAD kinase in neutrophils

2016
NADP+ and NADPH are involved in many biosynthetic pathways and signal transduction mechanisms. NAD kinase (NADK) is the only known enzyme that catalyzes the de novo synthesis of NADP+ from NAD+. In neutrophils, NADK plays an essential role to provide sufficient levels of NADPH to support a robust respiratory burst.
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Compact NAD mimics as selective inhibitors of NAD kinases

2009
We have examined sequence diversity of 147 co-crystal structures of proteins utilizing NAD as a cofactor or as a substrate. Most of these proteins bind NAD in an extended conformation (e.g. the distance between the adenine 6-amino group of NAD and the nicotinamide amide carbon is 16 Å or more). However, there are clear exceptions to this general trend.
PETRELLI, Riccardo, SHAM Y. Y, CHEN L, FELCZAK, K, DI STEFANO M, MAGNI G, PANKIEWICZ K. W.   +6 more
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Effect of Methotrexate on NAD Kinase Activity in Leukaemic Mice

Nature, 1967
IN the course of treatment of leukaemia L1210 in mice using an antifolate compound, methotrexate (MTX), the leukaemic cells are affected early during treatment and later, while becoming resistant1, show impaired retention and decreased permeability to the drug2–4.
Mhatre, R M, Saslaw, L D, Waravdekar, V S   +2 more
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[119] NAD+ kinase in liver tissue

1971
Publisher Summary This chapter discusses the assay method, purification procedure, and properties of the enzyme nicotinamide adenine dinucleotide (NAD + ) kinase in frozen rat and calf liver tissue. The nicotinamide adenine dinucleotide phosphate (NADP + ) formed in the reaction mixture is assayed by method based on the measurement of the change in ...
L.S. Dietrich, I.L. Yero
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Immobilization of NAD Kinase

Annals of the New York Academy of Sciences, 1984
X S, Ji, H X, Li, Z Y, Yuan, S H, Liu
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[Interaction of NAD-kinase with glutamate dehydrogenase].

Biokhimiia (Moscow, Russia), 1988
The formation of a NAD kinase-glutamate dehydrogenase complex was studied, using three independent methods. It was found that the polymeric form of glutamate dehydrogenase is involved in the formation of a complex with NAD kinase. Both the oligomeric and monomeric (subunit) forms of NAD kinase were shown to possess the ability to form complexes with ...
O L, Voronina, E R, Bulygina, V I, Telepneva   +2 more
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