Results 1 to 10 of about 30,416 (196)

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells [PDF]

Molecular Metabolism, 2017
Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appear
Gareth Lavery, Lucy Oakey, Craig L Doig   +2 more
exaly   +9 more sources

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD+ by Generating Dihydronicotinamide Riboside

Nutrients, 2022
Through evolution, eukaryote organisms have developed the ability to use different molecules as independent precursors to generate nicotinamide adenine dinucleotide (NAD+), an essential molecule for life. However, whether these different precursors act in an additive or complementary manner is not truly well understood.
Judith Giroud-Gerbetant, Sofia Moco, Carles Canto   +2 more
exaly   +6 more sources

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells [PDF]

Nature Communications, 2016
Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide ...
Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner, Carles Cantó   +13 more
doaj   +10 more sources

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives

Beilstein Journal of Organic Chemistry, 2019
The β-anomeric form of nicotinamide riboside (NR+) is a precursor for nicotinamide adenine dinucleotide (NAD+), a redox cofactor playing a critical role in cell metabolism. Recently, it has been demonstrated that its chloride salt (NR+Cl−) has beneficial
Mikhail Makarov, Marie E Migaud
exaly   +3 more sources

Nicotinamide Riboside: What It Takes to Incorporate It into RNA. [PDF]

Molecules
Nicotinamide is an important functional compound and, in the form of nicotinamide adenine dinucleotide (NAD), is used as a cofactor by protein-based enzymes to catalyze redox reactions. In the context of the RNA world hypothesis, it is therefore reasonable to assume that ancestral ribozymes could have used cofactors such as NAD or its simpler analog ...
Wenzek F, Biallas A, Müller S.
europepmc   +6 more sources

Molecular Engineering of Nicotinamide Riboside Kinase and Process Optimization for Efficient Nicotinamide Mononucleotide Production [PDF]

Foods
Nicotinamide mononucleotide (NMN) plays vital physiological roles as a vitamin B derivative, with nicotinamide riboside kinase (NRK) serving as a key enzyme for its efficient and environmentally friendly synthesis. In this study, semi-rational design was
Dai Ma, Rui Liu, Tong Bao, Jingwen Yang, Hongbin Zhang, Xueqin Hu   +5 more
doaj   +2 more sources

Emerging Role of Nicotinamide Riboside in Health and Diseases

Nutrients, 2022
Among all the NAD+ precursors, nicotinamide riboside (NR) has gained the most attention as a potent NAD+-enhancement agent. This recently discovered vitamin, B3, has demonstrated excellent safety and efficacy profiles and is orally bioavailable in humans.
Yana Cen, Chiranjeev Sharma, Dickson Donu   +2 more
exaly   +3 more sources

Nicotinamide Riboside Attenuates Cisplatin-Induced Hepatorenal Toxicity Through Restoration of NAD⁺ Homeostasis and Nrf2/NQO1-Dependent Antioxidant Signaling [PDF]

Cells
Background: Cisplatin is a widely used chemotherapeutic agent whose clinical application is often limited by severe hepatorenal toxicity associated with oxidative stress and cellular injury. Nicotinamide riboside (NR), a natural precursor of nicotinamide
Waleed Khaled Younis Albahadly, Mohammed Ibrahim Rasool, Haider Falih Shamikh Al-Saedi, Zahraa Abed Al-Kareem, Samer Ali Hasan, Mohammed Abdulaali Sahib, Meeqaat H. ALtrufi   +6 more
doaj   +2 more sources

Insulin and glycolysis dependency of cardioprotection by nicotinamide riboside. [PDF]

Basic Res Cardiol
AbstractDecreased nicotinamide adenine dinucleotide (NAD+) levels contribute to various pathologies such as ageing, diabetes, heart failure and ischemia–reperfusion injury (IRI). Nicotinamide riboside (NR) has emerged as a promising therapeutic NAD+ precursor due to efficient NAD+ elevation and was recently shown to be the only agent able to reduce ...
Xiao Y, Wang Q, Zhang H, Nederlof R, Bakker D, Siadari BA, Wesselink MW, Preckel B, Weber NC, Hollmann MW, Schomakers BV, van Weeghel M, Zuurbier CJ.   +12 more
europepmc   +4 more sources

Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout mice

Frontiers in Immunology, 2023
Nicotinamide adenine dinucleotide (NAD) is a substrate of adenosine diphosphate (ADP)-ribosyl cyclase and is catalyzed to cyclic ADP-ribose (cADPR) by CD38 and/or CD157.
Maria Gerasimenko, Haruhiro Higashida
doaj   +1 more source