Results 11 to 20 of about 5,674 (135)

Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Midlife and Older Adults

Frontiers in Cardiovascular Medicine, 2022
BackgroundAging is the primary risk factor for cardiovascular diseases, the leading cause of death worldwide. Age-related increases in systolic blood pressure (SBP) link advancing age to cardiovascular disease risk. A key mechanism mediating the increase
Kaitlin A. Freeberg, Daniel H. Craighead, Christopher R. Martens, Zhiying You, Michel Chonchol, Douglas R. Seals   +5 more
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Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure

Molecular Metabolism, 2022
Objective: Disturbances in NAD+ metabolism have been described as a hallmark for multiple metabolic and age-related diseases, including type 2 diabetes.
Angelique Cercillieux, Joanna Ratajczak, Magali Joffraud, José Luis Sanchez-Garcia, Guillaume Jacot, Alix Zollinger, Sylviane Métairon, Judith Giroud-Gerbetant, Marie Rumpler, Eleonora Ciarlo, Miriam Valera-Alberni, Audrey Sambeat, Carles Canto   +12 more
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The Role of NAD⁺ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance

Biomedicines, 2023
Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In
Tatjana Ruskovska, David A. Bernlohr
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Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

Scientific Reports, 2020
Oxytocin (OT) is a critical molecule for social recognition and memory that mediates social and emotional behaviours. In addition, OT acts as an anxiolytic factor and is released during stress. Based on the activity of CD38 as an enzyme that produces the
Maria Gerasimenko, Stanislav M. Cherepanov, Kazumi Furuhara, Olga Lopatina, Alla B. Salmina, Anna A. Shabalova, Chiharu Tsuji, Shigeru Yokoyama, Katsuhiko Ishihara, Charles Brenner, Haruhiro Higashida   +10 more
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Precursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging

Aging Medicine, 2021
Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in every human cell and regulates a number of systems across multiple cellular compartments and tissue types via an endogenous and exogenous influence.
Raymond D. Palmer, Magdy Mahmoud Elnashar, Mauro Vaccarezza   +2 more
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Epithelial NAD+ depletion drives mitochondrial dysfunction and contributes to intestinal inflammation

Frontiers in Immunology, 2023
IntroductionWe have previously demonstrated that a pathologic downregulation of peroxisome proliferator-activated receptor–gamma coactivator 1-alpha (PGC1α) within the intestinal epithelium contributes to the pathogenesis of inflammatory bowel disease ...
Elizabeth A. Novak, Elizabeth A. Novak, Erin C. Crawford, Heather L. Mentrup, Heather L. Mentrup, Brian D. Griffith, David M. Fletcher, Meredith R. Flanagan, Corinne Schneider, Corinne Schneider, Brian Firek, Brian Firek, Matthew B. Rogers, Matthew B. Rogers, Michael J. Morowitz, Michael J. Morowitz, Jon D. Piganelli, Jon D. Piganelli, Qian Wang, Kevin P. Mollen, Kevin P. Mollen   +20 more
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Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

Cell Reports, 2019
Summary: Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but human data are sparse.
Yasir S. Elhassan, Katarina Kluckova, Rachel S. Fletcher, Mark S. Schmidt, Antje Garten, Craig L. Doig, David M. Cartwright, Lucy Oakey, Claire V. Burley, Ned Jenkinson, Martin Wilson, Samuel J.E. Lucas, Ildem Akerman, Alex Seabright, Yu-Chiang Lai, Daniel A. Tennant, Peter Nightingale, Gareth A. Wallis, Konstantinos N. Manolopoulos, Charles Brenner, Andrew Philp, Gareth G. Lavery   +21 more
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Review on Biosynthesis of β-Nicotinamide Mononucleotide and Its Derivatives [PDF]

Shipin Kexue
β-Nicotinamide mononucleotide (NMN) is present in all organisms and has attracted widespread attention as a nutritional supplement and pharmaceutical product for the treatment of various diseases, such as Alzheimer’s disease, cancer, aging, and vascular ...
WANG Zhaoying, GUO Xinhao, HUANG Xinhe, CHEN Zhuoyan, LIU Yueqi, LI Juan, CHEN Ning, FAN Xiaoguang
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Enzymatic synthesis of high-titer nicotinamide mononucleotide with a new nicotinamide riboside kinase and an efficient ATP regeneration system

Bioresources and Bioprocessing, 2022
Background β-Nicotinamide mononucleotide (NMN) is the direct precursor of nicotinamide coenzymes such as NAD+ and NADP+, which are widely applied in industrial biocatalysis especially involving cofactor-dependent oxidoreductases.
Xiao-Long Qian, Yi-Si Dai, Chun-Xiu Li, Jiang Pan, Jian-He Xu, Bozhong Mu   +5 more
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Nicotinamide riboside kinase structures reveal new pathways to NAD+.

PLoS Biology, 2007
The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and ...
Wolfram Tempel, Wael M Rabeh, Katrina L Bogan, Peter Belenky, Marzena Wojcik, Heather F Seidle, Lyudmila Nedyalkova, Tianle Yang, Anthony A Sauve, Hee-Won Park, Charles Brenner   +10 more
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