Results 1 to 10 of about 36,040 (208)

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells [PDF]

Nature Communications, 2016
Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide ...
Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner, Carles Cantó   +13 more
doaj   +10 more sources

Identification of the nicotinamide mononucleotide adenylyltransferase of Trypanosoma cruzi [PDF]

Memorias do Instituto Oswaldo Cruz, 2015
The intracellular parasite Trypanosomacruzi is the aetiological agent of Chagas disease, a public health concern with an increasing incidence rate. This increase is due, among other reasons, to the parasite’s drug resistance mechanisms, which require ...
Carlos H Niño, Nicolás Forero-Baena, Luis E Contreras, Diana Sánchez-Lancheros, Katherine Figarella, María H Ramírez   +5 more
doaj   +5 more sources

Nicotinamide Mononucleotide Enhances Boar Sperm Quality via Maintaining Mitochondrial Function During Liquid Storage [PDF]

Animals
Nicotinamide mononucleotide (NMN), a key precursor of nicotinamide adenine dinucleotide (NAD+), plays a central role in cellular energy metabolism. This study investigated the effect of NMN supplementation on boar sperm quality during liquid storage ...
Yongjin Liu, Hongyan Zhang, Qingzhe Meng, Lingjiang Min, Min Zhang, Adedeji O. Adetunji, Wenjing Li, Zhendong Zhu   +7 more
doaj   +3 more sources

Slc12a8 is a nicotinamide mononucleotide transporter [PDF]

Nature Metabolism, 2019
Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD+ known to promote cellular NAD+ production and counteract age-associated pathologies associated with a decline in tissue NAD+ levels. How NMN is taken up into cells has not been entirely clear. Here we show that the Slc12a8 gene encodes a specific NMN transporter. We find that Slc12a8
Grozio, Alessia, Mills, Kathryn F, Yoshino, Jun, Bruzzone, Santina, Sociali, Giovanna, Tokizane, Kyohei, Lei, Hanyue Cecilia, Cunningham, Richard, Sasaki, Yo, Migaud, Marie E, Imai, Shin-Ichiro   +10 more
openaire   +4 more sources

Investigation of the effects of nicotinamide mononucleotide on kidney damage in rats with cecal ligation and perforation sepsis model [PDF]

Acta Cirúrgica Brasileira
Purpose: To evaluate the protective effects of nicotinamide mononucleotide (NMN), a NAD+ precursor, on kidney tissue in rats with sepsis induced by cecal ligation and puncture model.
Ayla Arslan, Dilek Vural Keleş, Seçil Nazife Parlak, Seda Yakut, Habibe Gündoğdu, İrem Arslantürk, Gökçe Bağcı Uzun, Berna Öztürk Karagöz   +7 more
doaj   +3 more sources

Enzymatic synthesis of polymers containing nicotinamide mononucleotide [PDF]

Nucleic Acids Research, 1995
Nicotinamide mononucleoside 5'-diphosphate in its reduced form is an excellent substrate for polynucleotide phosphorylase from Micrococcus luteus both in de novo polymerization reactions and in primer extension reactions. The oxidized form of the diphosphate is a much less efficient substrate; it can be used to extend primers but does not oligomerize ...
R, Liu, L E, Orgel
core   +6 more sources

Antioxidant effect of nicotinamide mononucleotide in tendinopathy

BMC Musculoskeletal Disorders, 2022
Background A link between tendinopathy and oxidative stress has been recently reported. Nicotinamide mononucleotide (NMN) is a precursor of nicotinamide adenine dinucleotide, which plays an important role in cell redox homeostasis.
Kohei Yamaura, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Shintaro Mukohara, Yuichi Hoshino, Takahiro Niikura, Ryosuke Kuroda   +8 more
doaj   +3 more sources

Biosynthesis of Nicotinamide Mononucleotide: Current Metabolic Engineering Strategies, Challenges, and Prospects

Fermentation, 2023
Nicotinamide mononucleotide (NMN) is an essential precursor of nicotinamide adenine dinucleotide (NAD+), which is widely applied in the pharmaceutical and biotech industries.
Shiqi Luo, Juntao Zhao, Yangyang Zheng, Tao Chen, Zhiwen Wang   +4 more
doaj   +2 more sources

Structure and Function of Nicotinamide Mononucleotide Adenylyltransferase

Current Medicinal Chemistry, 2004
The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT), a member of the nucleotidyltransferase alpha/beta phosphodiesterase superfamily, catalyzes the reaction NMN + ATP = NAD + PPi, representing the final step in the biosynthesis of NAD, a molecule playing a fundamental role as a cofactor in cellular redox reactions. NAD also serves as the
G, Magni, A, Amici, M, Emanuelli, G, Orsomando, N, Raffaelli, S, Ruggieri   +5 more
openaire   +3 more sources

Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells

MedComm, 2021
Alveolar epithelial cells (ACEs) gradually senescent as aging, which is one of the main causes of respiratory defense and function decline. Investigating the mechanisms of ACE senescence is important for understanding how the human respiratory system ...
Tingting Fang, Jingyun Yang, Li Liu, Hengyi Xiao, Xiawei Wei   +4 more
doaj   +2 more sources