β-Nicotinamide Mononucleotide Inhibits Cellular Senescence in Mouse C2C12 Skeletal Muscle Cells [PDF]
Journal of Aging Researchβ-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD+), has remarkable therapeutic potential in aging-associated diseases.
Jing Mi +8 more
doaj +2 more sources
AARS2-SIRT5-Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells. [PDF]
Adv Sci (Weinh)Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Ding M +12 more
europepmc +2 more sources
Metabolic Engineering of Pseudomonas putida KT2440 for β-Nicotinamide Mononucleotide Biosynthesis from Glucose and Aspartate [PDF]
Microorganismsβ-Nicotinamide mononucleotide (NMN) is an important intermediate in nicotinamide adenine dinucleotide (NAD+) metabolism and has attracted increasing interest as a bioactive compound and biomanufacturing product.
Luna Gao +7 more
doaj +2 more sources
NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota
Frontiers in Nutrition, 2021 The aim of this study was to determine the effects of long-term Nicotinamide mononucleotide (NMN) treatment on modulating gut microbiota diversity and composition, as well as its association with intestinal barrier function.
Aihua Gong, Yan Zhou, Caifang Ren
exaly +3 more sources
Brain-targeting lipid nanoparticles of nicotinamide mononucleotide: preparation, optimization, and characterization [PDF]
Frontiers in ChemistryNicotinamide mononucleotide (NMN) has anti-inflammatory, antioxidant, and mitochondrial function-enhancing properties, which demonstrate its significant neuroprotective potential.
Yuxian Lin +9 more
doaj +2 more sources
Cells, 2020 Maternal obesity impacts offspring metabolism. We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) to treat metabolic impairment induced by maternal and long ...
David A. Sinclair +2 more
exaly +3 more sources
High-Level Production of NMN in Escherichia coli Through Co-Utilization of Glucose and Glycerol [PDF]
MicroorganismsNicotinamide mononucleotide (NMN), a direct precursor of the essential coenzyme nicotinamide adenine dinucleotide (NAD+), confers anti-aging effects and multiple health benefits.
Jiajia Gan +5 more
doaj +2 more sources
NMN protects vascular endothelial cells from M1 macrophage-derived IL-1β-induced hyperpermeability by inhibiting VE-cadherin degradation [PDF]
Frontiers in Cardiovascular MedicineBackground and aimsVascular endothelial (VE) dysfunction, particularly endothelial hyperpermeability, is a critical pathological process in various inflammatory vascular diseases, including atherosclerosis, vasculitis, and sepsis.
Takeshi Katayoshi +9 more
doaj +2 more sources
Biochemistry and Biophysics Reports, 2023 Nicotinamide adenine dinucleotide (NAD+) -dependent protein deacetylase SIRT1 plays an important role in the regulation of metabolism. Although the administration of nicotinamide mononucleotide (NMN), a key NAD+ intermediate, has been shown to ameliorate
Yukiko Imi +4 more
doaj +1 more source
Determination of β-Nicotinamide Mononucleotide (NMN) in NMN Cross Border Products
Shipin gongye ke-ji, 2022 By optimizing the chromatographic conditions and sample pretreatment conditions, a method for determination of NMN content in NMN capsules and NMN tablets matrix was established based on high performance liquid chromatography, and the methodology was ...
Wenyu ZHANG +8 more
doaj +1 more source